A5014041200- Bone health and osteoporosis research
- Hip and Femur Fractures
- Health Systems, Economic Evaluations, Quality of Life
- Hormonal and reproductive studies
- Dementia and Cognitive Impairment Research
- Nutrition and Health in Aging
- Urinary Bladder and Prostate Research
- Sexual function and dysfunction studies
- Bone and Joint Diseases
- Bone health and treatments
- Vitamin D Research Studies
- Pelvic floor disorders treatments
- Pelvic and Acetabular Injuries
- Restless Legs Syndrome Research
- Pharmaceutical studies and practices
- Musculoskeletal pain and rehabilitation
- Frailty in Older Adults
- Diet and metabolism studies
- Spine and Intervertebral Disc Pathology
- Nutritional Studies and Diet
- Thyroid Disorders and Treatments
- Hip disorders and treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Statistical Methods in Clinical Trials
- Urinary Tract Infections Management
Geriatric Research Education and Clinical Center
2016-2025
University of Minnesota
2016-2025
Minneapolis VA Health Care System
2016-2025
Health Services Research & Development
2025
Minnesota Department of Health
2013-2024
University of California, San Francisco
2004-2022
San Francisco VA Health Care System
2022
University of Minnesota Medical Center
2000-2021
United States Department of Veterans Affairs
2006-2019
Minneapolis VA Medical Center
2003-2018
Background. A standard phenotype of frailty was associated with an increased risk adverse outcomes including mortality in a recent study older adults. However, the predictive validity this for fracture and across subgroups is uncertain. Methods. To determine whether independently health women to evaluate consistency associations defined by age body mass index (BMI), we ascertained status cohort 6724 ≥ 69 years followed them prospectively incident falls, fractures, mortality. Frailty presence...
OBJECTIVES: To compare the validity of a parsimonious frailty index (components: weight loss, inability to rise from chair, and poor energy (Study Osteoporotic Fractures (SOF) index)) with that more complex Cardiovascular Health Study (CHS) unintentional low grip strength, energy, slowness, physical activity) for prediction adverse outcomes in older men. DESIGN: Prospective cohort study. SETTING: Six U.S. centers. PARTICIPANTS: Three thousand one hundred thirty‐two men aged 67 older....
Objectives: To determine the association between vision and hearing impairment subsequent cognitive functional decline in community‐residing older women. Design: Prospective cohort study. Setting: Four metropolitan areas of United States. Participants: A total 6,112 women aged 69 participating Study Osteoporotic Fractures (SOF) 1992 1994. Measurements: Five thousand three hundred forty‐five participants had measured, 1,668 visual acuity 1,636 both measured. Visual was defined as corrected...
The association between objectively measured sleep and cognition among community-dwelling elderly persons remains understudied. This observational, cross-sectional analysis examined this association.Results are from 2932 women (mean age 83.5 years) in the Study of Osteoporotic Fractures 2002 2004. Cognitive function was by Mini-Mental State Examination (MMSE) Trail Making B Test (Trails B). impairment defined as MMSE < 26 or Trails > 278 seconds. Sleep parameters using actigraphy included...
Abstract We prospectively examined, in a large cohort of older women, the proportion incident radiographic vertebral deformities diagnosed as clinical fractures same women at level. The clinically ranged from &lt;15% for milder to nearly 30% more severe deformities. Introduction: relationship between and is incompletely understood. No previous study has compared agreement community-recognized, radiographically confirmed level(s). Materials Methods: This analysis data Fracture...
Abstract Introduction Mildly reduced renal function and elevated urine protein levels are each prospectively associated with hip fracture risk in older adults. Here we determine whether these markers appendicular muscle performance. Methods We examined the associations of albumin:creatinine ratio (ACR) estimated glomerular filtration rate (eGFR) longitudinal changes grip strength gait speed &gt;2 years 2317 community-dwelling men women (median age 77 years). The median ACR was 9.8...
The clinical value of measuring testosterone and estradiol in older men with osteoporosis bone mineral density (BMD) or deficiency is uncertain.The objective the study was to examine association rapid loss men.This a cross-sectional longitudinal analysis.The conducted at six U.S. centers Osteoporotic Fractures Men study.The population consisted 2447 community-dwelling aged 65 yr older.Total defined as less than 200 ng/dl. Total 10 pg/ml. Osteoporosis femoral neck total hip BMD T-score -2.5...
Objectives: To identify independent risk factors for first hip fracture over 10 years of follow‐up. Design: Prospective cohort study. Setting: Four U.S. clinical centers. Participants: A total 6,787 women aged 66 and older in the Study Osteoporotic Fractures. Measurements: Total bone mineral density (BMD) using dual‐energy x‐ray absorptiometry a comprehensive set potential were collected. Incident fractures identified prospectively confirmed radiographic report. Results: Six hundred two...
In a prospective study of 5384 older men, hip BMD was very strong predictor fracture, much stronger than spine BMD. The relationship between and fracture risk seemed to be observed in large women. Hip is an excellent test for predicting men.There have been few studies the fractures men none association lumbar nonvertebral fractures. There also controversy about whether associations are same women.We measured proximal femur >or= 65 years age. We compared results similar cohort 7871 women...
Objective: To test the hypothesis that lower 25-hydroxyvitamin D [25(OH)D] levels are associated with a greater likelihood of cognitive impairment and risk decline. Methods: We measured 25(OH)D assessed function using Modified Mini-Mental State Examination (3MS) Trail Making Test Part B (Trails B) in cohort 1,604 men enrolled Osteoporotic Fractures Men Study followed them for an average 4.6 years changes function. Results: In model adjusted age, season, site, seemed to have higher odds...
Fractures have been associated with subsequent increases in mortality, but it is unknown how long that increase persists.A total of 5580 women from a large community-based, multicenter US prospective cohort 9704 (Study Osteoporotic Fractures) were observed prospectively for almost 20 years. We age-matched 1116 hip fracture cases 4 control participants (n = 4464). To examine the effect health status, we examined healthy older subset 960) 80 years or who attended 10-year follow-up examination...
Osteoporotic fractures are common among elderly men.To evaluate older men the cost-effectiveness of bone densitometry followed by 5 years oral bisphosphonate therapy to prevent for those found have osteoporosis (femoral neck T score < or =-2.5), compared with no intervention.Computer Markov microsimulation model using a societal perspective and lifetime horizon. Simulations were performed hypothetical cohorts white aged 65, 70, 75, 80, 85 years, without prior clinical fracture. Data sources...
OBJECTIVE To evaluate the association of lower urinary tract symptoms (LUTS) with risk falls in elderly community‐dwelling men. SUBJECTS AND METHODS We evaluated 5872 participants Osteoporotic Fractures Men, a prospective cohort study factors for and osteoporotic fractures among men aged ≥65 years. The primary outcome was 1‐year cumulative incidence moderate or severe, vs mild LUTS at baseline, as measured by American Urological Association Symptom Index. used Poisson regression models...
Abstract We examined determinants of nonvertebral fracture in elderly men from six U.S. communities followed an average 4.1 years. Six clinical risk factors predicted independent hip BMD: tricyclic antidepressant use, previous fracture, inability to complete a narrow walk trial, falls year, age ≥80 years, and depressed mood. Introduction: There are few prospective studies men. the associations between comprehensive set nonspine older whether were total BMD. Materials Methods: A 5995 ≤65...