A5046940384- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Asthma and respiratory diseases
- Pediatric health and respiratory diseases
- Neonatal Respiratory Health Research
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Blood transfusion and management
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Respiratory and Cough-Related Research
- Cardiac and Coronary Surgery Techniques
- Inhalation and Respiratory Drug Delivery
- Diverse Educational Innovations Studies
- Gut microbiota and health
- Connective tissue disorders research
- Blood Coagulation and Thrombosis Mechanisms
- Pulmonary Hypertension Research and Treatments
- Composting and Vermicomposting Techniques
- Phosphodiesterase function and regulation
- Mechanical Circulatory Support Devices
- Respiratory viral infections research
- Delphi Technique in Research
- Occupational and environmental lung diseases
- Congenital Heart Disease Studies
- Cardiovascular Health and Disease Prevention
- Nursing Diagnosis and Documentation
COPD Foundation
2021-2025
Neurology, Inc
2025
Respiratory Clinical Trials
2017-2024
GlaxoSmithKline (United States)
2014-2023
British Heart Foundation
2023
University of Leicester
2023
University of Nottingham
2017-2023
European Federation of Allergy and Airways Diseases Patients Associations
2023
University of Edinburgh
2023
University of Dundee
2023
Although we know that exacerbations are key events in chronic obstructive pulmonary disease (COPD), our understanding of their frequency, determinants, and effects is incomplete. In a large observational cohort, tested the hypothesis there frequent-exacerbation phenotype COPD independent severity.We analyzed frequency associations exacerbation 2138 patients enrolled Evaluation Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) study. Exacerbations were defined as led care...
Chronic obstructive pulmonary disease (COPD) is a complex condition with and extra-pulmonary manifestations. This study describes the heterogeneity of COPD in large well characterised controlled cohort (ECLIPSE). We studied 2164 clinically stable patients, 337 smokers normal lung function 245 never smokers. In these individuals, we measured clinical parameters, nutritional status, spirometry, exercise tolerance, amount emphysema by computed tomography. patients were slightly older than...
A key feature of chronic obstructive pulmonary disease (COPD) is an accelerated rate decline in forced expiratory volume 1 second (FEV(1)), but data on the variability and determinants this change patients who have established are scarce.We analyzed changes FEV(1) after administration a bronchodilator over 3-year period 2163 patients. random-coefficient model was used to evaluate possible predictors both levels their time.The mean (±SE) 33±2 ml per year, with significant variation among...
Background Because chronic obstructive pulmonary disease (COPD) is a heterogeneous condition, the identification of specific clinical phenotypes key to developing more effective therapies. To explore if persistence systemic inflammation associated with poor outcomes in COPD we assessed patients recruited well-characterized ECLIPSE cohort (NCT00292552). Methods and Findings Six inflammatory biomarkers peripheral blood (white cells (WBC) count CRP, IL-6, IL-8, fibrinogen TNF-α levels) were...
Rationale: Accurate prediction of mortality helps select patients for interventions aimed at improving outcome.Objectives: Because chronic obstructive pulmonary disease is characterized by low-grade systemic inflammation, we hypothesized that addition inflammatory biomarkers to established predictive factors will improve accuracy.Methods: A total 1,843 enrolled in the Evaluation COPD Longitudinally Identify Predictive Surrogate Endpoints study were followed 3 years. Kaplan-Meier curves,...
Increasing evidence suggests that the lung microbiome plays an important role in chronic obstructive pulmonary disease (COPD) severity. However, dynamics of during COPD exacerbations and its potential aetiology remain poorly understood.We completed a longitudinal 16S ribosomal RNA survey on 476 sputum samples collected from 87 subjects with at four visits defined as stable state, exacerbation, 2 weeks post-therapy 6 recovery.Our analysis revealed dynamic microbiota where changes appeared to...
Outcomes other than spirometry are required to assess nonbronchodilator therapies for chronic obstructive pulmonary disease. Estimates of the minimal clinically important difference 6-minute-walk distance (6MWD) have been derived from narrow cohorts using nonblinded intervention.To determine minimum change in 6MWD over 1 year as a function mortality and first hospitalization an observational cohort patients with COPD.Data ECLIPSE were used (n = 2,112). Death or index events; we measured...
Background Alterations in the composition of lung microbiome associated with adverse clinical outcomes, known as dysbiosis, have been implicated disease severity and exacerbations COPD. Objective To characterise longitudinal changes AERIS study (Acute Exacerbation Respiratory InfectionS COPD) their relationship COPD outcomes. Methods We surveyed 584 sputum samples from 101 patients to analyse at both stable exacerbation time points over 1 year using high-throughput sequencing 16S ribosomal...
Understanding the role of airway microbiome in chronic obstructive pulmonary disease (COPD) inflammatory endotypes may help to develop microbiome-based diagnostic and therapeutic approaches.
Surfactant protein (SP)-D is a lung-derived that has been proposed as biomarker for inflammatory lung disease. Serum SP-D was evaluated components of chronic obstructive pulmonary disease (COPD) in the Evaluation COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) cohort and its response assessed administration anti-inflammatory agent prednisolone. The median level serum significantly elevated 1,888 individuals with compared 296 current former smokers without airflow...
<h3>Background:</h3> Circulating levels of Clara cell secretory protein-16 (CC-16) have been linked to toxicity. It has therefore suggested that this protein may be a useful marker chronic obstructive pulmonary disease (COPD). <h3>Methods:</h3> Serum CC-16 were measured in 2083 individuals aged 40–75 years with COPD and smoking history ⩾10 pack-years, 332 controls pack-years normal lung function 237 non-smoking controls. <h3>Results:</h3> had coefficient repeatability 2.90 over 3 months...
The 2011 Global Initiative for Chronic Obstructive Lung Disease (GOLD) classifies patients with chronic obstructive pulmonary disease (COPD) into four groups (A to D). We explored the characteristics, stability and relationship outcomes of these within ECLIPSE study (Evaluation COPD Longitudinally Identify Predictive Surrogate End-points) (n = 2101). Main results showed that: 1) differed in several clinical, functional, imaging biological characteristics addition those used their own...
Bronchodilator responsiveness is a potential phenotypic characteristic of chronic obstructive pulmonary disease (COPD). We studied whether change in lung function after bronchodilator abnormal COPD, stable responder subgroups can be identified, and these experience different clinical outcomes.1831 patients with 285 smoking (SC) 228 non-smoking (NSC) controls from the Evaluation COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) cohort. Spirometric reversibility 400 μg...
Coronary artery calcification is pathognomonic of coronary disease (CAD). Whether CAD in patients with COPD linked to lung function, functional capacity and/or clinically relevant outcomes unknown. The objective was assess the association between and severity, COPD.Coronary calcium score (CACS; Agatston score) measured using chest CT COPD, smokers normal spirometry non-smokers from Evaluation Longitudinally Identify Predictive Surrogate Endpoints (ECLIPSE) study.CACS 942 subjects: 672 (mean...
Rationale: Emphysema in chronic obstructive pulmonary disease (COPD) can be characterized by high-resolution chest computed tomography (HRCT); however, the repeated use of HRCT is limited because concerns regarding radiation exposure and cost.Objectives: To evaluate biomarkers associated with emphysema COPD-related clinical characteristics, to assess relationships soluble receptor for advanced glycation endproducts (sRAGE), a candidate systemic biomarker identified this study,...
Abstract Background There is a need for biomarkers to better characterise individuals with COPD and aid the development of therapeutic interventions. A panel putative blood was assessed in subgroup Evaluation Longitudinally Identify Surrogate Endpoints (ECLIPSE) cohort. Methods Thirty-four were 201 subjects COPD, 37 ex-smoker controls normal lung function healthy non-smokers selected from ECLIPSE Biomarker repeatability using baseline 3-month samples. Intergroup comparisons made analysis...
Chronic obstructive pulmonary disease (COPD) is a heterogeneous that likely includes clinically relevant subgroups.To identify subgroups of COPD in ECLIPSE (Evaluation Longitudinally to Identify Predictive Surrogate Endpoints) subjects using cluster analysis and assess meaningful outcomes the clusters during 3 years longitudinal follow-up.Factor was used reduce 41 variables determined at recruitment 2,164 patients with 13 main factors, highest loading were for analysis. Clusters evaluated...
Section:ChooseTop of pageAbstract <<The ECLIPSE Study (NCT002...COPD HeterogeneityThe Frequent Exacerbator ...Decline in FEV1Change CT-defined Dens...Bronchodilator Reversibil...Systemic InflammationFunctional COPD OutcomesComorbidities COPDConclusionsReferencesCITING ARTICLES