A5047450563- Chronic Obstructive Pulmonary Disease (COPD) Research
- Asthma and respiratory diseases
- Respiratory and Cough-Related Research
- Respiratory Support and Mechanisms
- Inhalation and Respiratory Drug Delivery
- Pulmonary Hypertension Research and Treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Neonatal Respiratory Health Research
- Allergic Rhinitis and Sensitization
- Bone health and osteoporosis research
- Pharmacological Effects and Assays
- Pharmaceutical studies and practices
- Vitamin D Research Studies
- Genital Health and Disease
- Pediatric health and respiratory diseases
- Cervical Cancer and HPV Research
- Connective tissue disorders research
- Colorectal and Anal Carcinomas
- Cardiovascular Function and Risk Factors
- Brucella: diagnosis, epidemiology, treatment
- Monoclonal and Polyclonal Antibodies Research
- Retinoids in leukemia and cellular processes
- Mental Health Treatment and Access
- Vascular Anomalies and Treatments
- Autoimmune Bullous Skin Diseases
University of Bradford
2022-2023
GlaxoSmithKline (United States)
2006-2022
University of California, Davis
2022
United Therapeutics (United States)
2019-2021
Triangle
1997-2021
University of Alabama at Birmingham
2021
Research Triangle Park Foundation
2005-2016
Salford Royal NHS Foundation Trust
2013-2016
University of Manchester
2008-2016
Manchester Academic Health Science Centre
2016
Chronic obstructive pulmonary disease (COPD) is a complex condition with and extra-pulmonary manifestations. This study describes the heterogeneity of COPD in large well characterised controlled cohort (ECLIPSE). We studied 2164 clinically stable patients, 337 smokers normal lung function 245 never smokers. In these individuals, we measured clinical parameters, nutritional status, spirometry, exercise tolerance, amount emphysema by computed tomography. patients were slightly older than...
A key feature of chronic obstructive pulmonary disease (COPD) is an accelerated rate decline in forced expiratory volume 1 second (FEV(1)), but data on the variability and determinants this change patients who have established are scarce.We analyzed changes FEV(1) after administration a bronchodilator over 3-year period 2163 patients. random-coefficient model was used to evaluate possible predictors both levels their time.The mean (±SE) 33±2 ml per year, with significant variation among...
Background Because chronic obstructive pulmonary disease (COPD) is a heterogeneous condition, the identification of specific clinical phenotypes key to developing more effective therapies. To explore if persistence systemic inflammation associated with poor outcomes in COPD we assessed patients recruited well-characterized ECLIPSE cohort (NCT00292552). Methods and Findings Six inflammatory biomarkers peripheral blood (white cells (WBC) count CRP, IL-6, IL-8, fibrinogen TNF-α levels) were...
Chronic obstructive pulmonary disease (COPD) is a heterogeneous and not well understood. The forced expiratory volume in one second used for the diagnosis staging of COPD, but there wide acceptance that it crude measure insensitive to change over shorter periods time. Evaluation COPD Longitudinally Identify Predictive Surrogate End-points (ECLIPSE) 3-yr longitudinal study with four specific aims: 1) definition clinically relevant subtypes; 2) identification parameters predict progression...
Rationale: Accurate prediction of mortality helps select patients for interventions aimed at improving outcome.Objectives: Because chronic obstructive pulmonary disease is characterized by low-grade systemic inflammation, we hypothesized that addition inflammatory biomarkers to established predictive factors will improve accuracy.Methods: A total 1,843 enrolled in the Evaluation COPD Longitudinally Identify Predictive Surrogate Endpoints study were followed 3 years. Kaplan-Meier curves,...
Outcomes other than spirometry are required to assess nonbronchodilator therapies for chronic obstructive pulmonary disease. Estimates of the minimal clinically important difference 6-minute-walk distance (6MWD) have been derived from narrow cohorts using nonblinded intervention.To determine minimum change in 6MWD over 1 year as a function mortality and first hospitalization an observational cohort patients with COPD.Data ECLIPSE were used (n = 2,112). Death or index events; we measured...
Surfactant protein (SP)-D is a lung-derived that has been proposed as biomarker for inflammatory lung disease. Serum SP-D was evaluated components of chronic obstructive pulmonary disease (COPD) in the Evaluation COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) cohort and its response assessed administration anti-inflammatory agent prednisolone. The median level serum significantly elevated 1,888 individuals with compared 296 current former smokers without airflow...
<h3>Background:</h3> Circulating levels of Clara cell secretory protein-16 (CC-16) have been linked to toxicity. It has therefore suggested that this protein may be a useful marker chronic obstructive pulmonary disease (COPD). <h3>Methods:</h3> Serum CC-16 were measured in 2083 individuals aged 40–75 years with COPD and smoking history ⩾10 pack-years, 332 controls pack-years normal lung function 237 non-smoking controls. <h3>Results:</h3> had coefficient repeatability 2.90 over 3 months...
The 2011 Global Initiative for Chronic Obstructive Lung Disease (GOLD) classifies patients with chronic obstructive pulmonary disease (COPD) into four groups (A to D). We explored the characteristics, stability and relationship outcomes of these within ECLIPSE study (Evaluation COPD Longitudinally Identify Predictive Surrogate End-points) (n = 2101). Main results showed that: 1) differed in several clinical, functional, imaging biological characteristics addition those used their own...
Bronchodilator responsiveness is a potential phenotypic characteristic of chronic obstructive pulmonary disease (COPD). We studied whether change in lung function after bronchodilator abnormal COPD, stable responder subgroups can be identified, and these experience different clinical outcomes.1831 patients with 285 smoking (SC) 228 non-smoking (NSC) controls from the Evaluation COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) cohort. Spirometric reversibility 400 μg...
Coronary artery calcification is pathognomonic of coronary disease (CAD). Whether CAD in patients with COPD linked to lung function, functional capacity and/or clinically relevant outcomes unknown. The objective was assess the association between and severity, COPD.Coronary calcium score (CACS; Agatston score) measured using chest CT COPD, smokers normal spirometry non-smokers from Evaluation Longitudinally Identify Predictive Surrogate Endpoints (ECLIPSE) study.CACS 942 subjects: 672 (mean...
The percentage of neutrophils in sputum are increased COPD patients, and may therefore be a biomarker airway inflammation. We studied the relationships between FEV1, health status, exacerbation rates, systemic inflammation emphysema, long term variability at 1 year. Sputum samples were obtained from 488 patients within ECLIPSE cohort. 359 baseline, 297 after 168 subjects provided both visits. Serum interleukin-6 (IL-6), IL-8, surfactant protein D C-reactive levels measured by immunoassays....
Genome-wide association studies have shown significant associations between variants near hedgehog interacting protein HHIP, FAM13A, and cholinergic nicotinic acetylcholine receptor CHRNA3/5 with increased risk of chronic obstructive pulmonary disease (COPD) in smokers; however, the mechanisms behind these are not well understood.To identify replicated loci COPD-related phenotypes well-characterized patient populations.The relationship three was assessed Evaluation COPD Longitudinally to...
Rationale: Emphysema in chronic obstructive pulmonary disease (COPD) can be characterized by high-resolution chest computed tomography (HRCT); however, the repeated use of HRCT is limited because concerns regarding radiation exposure and cost.Objectives: To evaluate biomarkers associated with emphysema COPD-related clinical characteristics, to assess relationships soluble receptor for advanced glycation endproducts (sRAGE), a candidate systemic biomarker identified this study,...
Abstract Background There is a need for biomarkers to better characterise individuals with COPD and aid the development of therapeutic interventions. A panel putative blood was assessed in subgroup Evaluation Longitudinally Identify Surrogate Endpoints (ECLIPSE) cohort. Methods Thirty-four were 201 subjects COPD, 37 ex-smoker controls normal lung function healthy non-smokers selected from ECLIPSE Biomarker repeatability using baseline 3-month samples. Intergroup comparisons made analysis...
Chronic obstructive pulmonary disease (COPD) is a heterogeneous that likely includes clinically relevant subgroups.To identify subgroups of COPD in ECLIPSE (Evaluation Longitudinally to Identify Predictive Surrogate Endpoints) subjects using cluster analysis and assess meaningful outcomes the clusters during 3 years longitudinal follow-up.Factor was used reduce 41 variables determined at recruitment 2,164 patients with 13 main factors, highest loading were for analysis. Clusters evaluated...