Michael H. Cho
A5018495347- Chronic Obstructive Pulmonary Disease (COPD) Research
- Asthma and respiratory diseases
- Genetic Associations and Epidemiology
- Pediatric health and respiratory diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Neonatal Respiratory Health Research
- Genetic Mapping and Diversity in Plants and Animals
- Pulmonary Hypertension Research and Treatments
- Genomics and Rare Diseases
- Bioinformatics and Genomic Networks
- Respiratory Support and Mechanisms
- Cancer-related molecular mechanisms research
- Acute Myeloid Leukemia Research
- Gene expression and cancer classification
- Genomic variations and chromosomal abnormalities
- Cancer Genomics and Diagnostics
- Delphi Technique in Research
- Genetic and phenotypic traits in livestock
- Respiratory and Cough-Related Research
- Lung Cancer Diagnosis and Treatment
- IL-33, ST2, and ILC Pathways
- Respiratory viral infections research
- Smoking Behavior and Cessation
Brigham and Women's Hospital
2016-2025
Harvard University
2016-2025
Pulmonary and Critical Care Associates
2013-2024
Beth Israel Deaconess Medical Center
2021-2024
Framingham Heart Study
2012-2024
Massachusetts General Hospital
2006-2024
Boston Children's Hospital
2024
Boston Medical Center
2024
University of Illinois Chicago
2024
Cornell University
2024
Abstract The Trans-Omics for Precision Medicine (TOPMed) programme seeks to elucidate the genetic architecture and biology of heart, lung, blood sleep disorders, with ultimate goal improving diagnosis, treatment prevention these diseases. initial phases focused on whole-genome sequencing individuals rich phenotypic data diverse backgrounds. Here we describe TOPMed goals design as well available resources early insights obtained from sequence data. include a variant browser, genotype...
Tracking longitudinal measurements of growth and decline in lung function patients with persistent childhood asthma may reveal links between subsequent chronic airflow obstruction.
<h3>Importance</h3> Interstitial lung abnormalities have been associated with lower 6-minute walk distance, diffusion capacity for carbon monoxide, and total capacity. However, to our knowledge, an association mortality has not previously investigated. <h3>Objective</h3> To investigate whether interstitial are increased mortality. <h3>Design, Setting, Population</h3> Prospective cohort studies of 2633 participants from the FHS (Framingham Heart Study; computed tomographic [CT] scans obtained...
Genetic variants influencing lung function in children and adults may ultimately lead to the development of chronic obstructive pulmonary disease (COPD), particularly high-risk groups.We tested for an association between single-nucleotide polymorphisms (SNPs) gene encoding matrix metalloproteinase 12 (MMP12) a measure (prebronchodilator forced expiratory volume 1 second [FEV(1)]) more than 8300 subjects seven cohorts that included adults. Within Normative Aging Study (NAS), cohort initially...
Tobacco and alcohol use are heritable behaviours associated with 15% 5.3% of worldwide deaths, respectively, due largely to broad increased risk for disease injury1-4. These substances used across the globe, yet genome-wide association studies have focused on individuals European ancestries5. Here we leveraged global genetic diversity 3.4 million from four major clines ancestry (approximately 21% non-European) power discovery fine-mapping genomic loci tobacco use, inform function these via...
Preserved Ratio Impaired Spirometry (PRISm), defined as a reduced FEV1 in the setting of preserved FEV1/FVC ratio, is highly prevalent and associated with increased respiratory symptoms, systemic inflammation, mortality. Studies investigating quantitative chest tomographic features, genetic associations, subtypes PRISm subjects have not been reported. Data from current former smokers enrolled COPDGene (n = 10,192), an observational, cross-sectional study which recruited aged 45–80 ≥10 pack...
Rationale: Idiopathic pulmonary fibrosis (IPF) is a complex lung disease characterized by scarring of the that believed to result from an atypical response injury epithelium. Genome-wide association studies have reported signals implicating multiple pathways including host defense, telomere maintenance, signaling, and cell-cell adhesion.Objectives: To improve our understanding factors increase IPF susceptibility identifying previously unreported genetic associations.Methods: We conducted...
Most genome-wide association and fine-mapping studies to date have been conducted in individuals of European descent, genetic populations Hispanic/Latino African ancestry are limited. In addition, these more complex linkage disequilibrium structure. order better define the architecture understudied populations, we leveraged >100,000 phased sequences available from deep-coverage whole genome sequencing through multi-ethnic NHLBI Trans-Omics for Precision Medicine (TOPMed) program impute...
Summary paragraph The Trans-Omics for Precision Medicine (TOPMed) program seeks to elucidate the genetic architecture and disease biology of heart, lung, blood, sleep disorders, with ultimate goal improving diagnosis, treatment, prevention. initial phases focus on whole genome sequencing individuals rich phenotypic data diverse backgrounds. Here, we describe TOPMed goals design as well resources early insights from sequence data. include a variant browser, genotype imputation panel, sharing...
Angiographic investigation suggests that pulmonary vascular remodeling in smokers is characterized by distal pruning of the blood vessels.Using volumetric computed tomography scans chest we sought to quantitatively evaluate this process and assess its clinical associations.Pulmonary vessels were automatically identified, segmented, measured. Total vessel volume (TBV) aggregate for less than 5 mm(2) (BV5) calculated all lobes. The lobe-specific BV5 measures normalized TBV lobe nonvascular...
Muscle wasting in chronic obstructive pulmonary disease (COPD) is associated with a poor prognosis and not readily assessed by measures of body mass index (BMI). BMI does discriminate between relative proportions adipose tissue lean muscle may be insensitive to early pathologic changes composition. Computed tomography (CT)-based assessments the pectoralis muscles provide insight into clinical significance skeletal smokers.
Increasing awareness of the prevalence and significance Preserved Ratio Impaired Spirometry (PRISm), alternatively known as restrictive or Global Initiative for Chronic Obstructive Lung Disease (GOLD)-unclassified spirometry, has expanded body knowledge on cross-sectional risk factors. However, longitudinal studies PRISm remain limited.
Rationale: Interstitial lung abnormalities (ILA) are radiologic on chest computed tomography scans that have been associated with an early or mild form of pulmonary fibrosis. Although ILA progression, it is not known if specific imaging patterns progression risk mortality.Objectives: To determine the role death and progression.Methods: (and pattern) were assessed in 5,320 participants from AGES-Reykjavik Study, was 3,167 participants. Multivariable logistic regression used to assess factors...
Abstract Chronic obstructive pulmonary disease (COPD) is associated with age and smoking, but other determinants of the are incompletely understood. Clonal hematopoiesis indeterminate potential (CHIP) a common, age-related state in which somatic mutations clonal blood populations induce aberrant inflammatory responses. Patients CHIP have an elevated risk for cardiovascular disease, association COPD remains unclear. We analyzed whole-genome sequencing whole-exome data to detect 48 835...
Large-scale deep-coverage whole-genome sequencing (WGS) is now feasible and offers potential advantages for locus discovery. We perform WGS in 16,324 participants from four ancestries at mean depth >29X analyze genotypes with quantitative traits-plasma total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density triglycerides. Common variant association yields known loci except few variants previously poorly imputed. Rare coding Mendelian dyslipidemia genes but rare...
Chronic obstructive pulmonary disease (COPD) remains a major cause of morbidity and mortality. Present-day diagnostic criteria are largely based solely on spirometric criteria. Accumulating evidence has identified substantial number individuals without COPD who suffer from respiratory symptoms and/or increased There is clear need for an expanded definition that linked to physiologic, structural (computed tomography [CT]) clinical disease. Using data the Genetic Epidemiology study (COPDGene
Airway mucus plugs are common in patients with chronic obstructive pulmonary disease (COPD); however, the association of airway plugging and mortality COPD is unknown.To determine whether identified on chest computed tomography (CT) were associated increased all-cause mortality.Observational retrospective analysis prospectively collected data a diagnosis Genetic Epidemiology cohort. Participants non-Hispanic Black or White individuals, aged 45 to 80 years, who smoked at least 10 pack-years....