A5021121714- Chronic Obstructive Pulmonary Disease (COPD) Research
- Asthma and respiratory diseases
- Respiratory Support and Mechanisms
- Pediatric health and respiratory diseases
- Respiratory and Cough-Related Research
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Inhalation and Respiratory Drug Delivery
- Respiratory viral infections research
- Neonatal Respiratory Health Research
- Eosinophilic Esophagitis
- Pulmonary Hypertension Research and Treatments
- Delphi Technique in Research
- Gut microbiota and health
- IL-33, ST2, and ILC Pathways
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Emergency and Acute Care Studies
- Pneumonia and Respiratory Infections
- Pleural and Pulmonary Diseases
- Nursing Diagnosis and Documentation
- SARS-CoV-2 and COVID-19 Research
- Lung Cancer Diagnosis and Treatment
- Non-Invasive Vital Sign Monitoring
- School Health and Nursing Education
- Childhood Cancer Survivors' Quality of Life
King's College London
2022-2025
University of Oxford
2015-2024
Medicines Evaluation Unit
2024
University of Ferrara
2024
German Center for Lung Research
2024
Manchester University NHS Foundation Trust
2024
LungenClinic Grosshansdorf
2024
Baylor College of Medicine
2023
National Institute for Health Research
2019-2023
Imperial College London
2021-2023
Exacerbations of chronic obstructive pulmonary disease (COPD) are heterogeneous with respect to inflammation and etiology.Investigate biomarker expression in COPD exacerbations identify biologic clusters determine biomarkers that recognize clinical exacerbation phenotypes, namely those associated bacteria, viruses, or eosinophilic airway inflammation.Patients were observed for 1 year at stable visits. Biomarkers measured sputum serum. Viruses selected bacteria assessed by polymerase chain...
Exacerbations of chronic obstructive pulmonary disease (COPD) and responses to treatment are heterogeneous.Investigate the usefulness blood eosinophils direct corticosteroid therapy during exacerbations.Subjects with COPD exacerbations were entered into a randomized biomarker-directed double-blind versus standard study. Subjects in arm received prednisolone for 2 weeks, whereas arm, or matching placebo was given according eosinophil count biomarker. Both study groups antibiotics. Blood...
Increasing evidence suggests that the lung microbiome plays an important role in chronic obstructive pulmonary disease (COPD) severity. However, dynamics of during COPD exacerbations and its potential aetiology remain poorly understood.We completed a longitudinal 16S ribosomal RNA survey on 476 sputum samples collected from 87 subjects with at four visits defined as stable state, exacerbation, 2 weeks post-therapy 6 recovery.Our analysis revealed dynamic microbiota where changes appeared to...
BackgroundAsthma and COPD are characterized by airway dysfunction inflammation. Neutrophilic inflammation is a common feature of recognized in asthma, particularly severe disease. The T helper (Th) 17 cytokines IL-17A IL-17F have been implicated the development neutrophilic inflammation, but their expression asthma uncertain.MethodsWe assessed bronchial submucosa from 30 subjects with 10 ex-smokers mild to moderate COPD, 27 nonsmoking 14 smoking control subjects. Sputum IL-17 concentration...
The efficacy and safety of benralizumab, an interleukin-5 receptor alpha–directed cytolytic monoclonal antibody, for the prevention exacerbations in patients with moderate to very severe chronic obstructive pulmonary disease (COPD) are not known.
In some patients with chronic obstructive pulmonary disease (COPD), type 2 inflammation may increase exacerbation risk and be indicated by elevated blood eosinophil counts. Dupilumab, a fully human monoclonal antibody, blocks the shared receptor component for interleukin-4 interleukin-13, key drivers of inflammation.In phase 3, double-blind, randomized trial, we assigned COPD who had count at least 300 per microliter an despite use standard triple therapy to receive dupilumab (300 mg) or...
The relationship between airway inflammation and obesity in severe asthma is poorly understood.We sought to determine the sputum mediator profiles distribution of eosinophilic people with asthma.Clinical parameters eight mediators were assessed 131 subjects from a single center categorized into lean, overweight, obese groups defined by their body mass index. In an independent group (n = 45) healthy control 19) was enumerated bronchial submucosa, blood, related index.Sputum IL-5 geometric...
On February 21, 2017, a European Respiratory Society research seminar held in Barcelona discussed how to best apply precision medicine chronic airway diseases such as asthma and obstructive pulmonary disease. It is now clear that both are complex heterogeneous diseases, often overlap require individualised assessment treatment. This paper summarises the presentations discussions took place during seminar. Specifically, we need for new taxonomy of human role different players this scenario...
Understanding the role of airway microbiome in chronic obstructive pulmonary disease (COPD) inflammatory endotypes may help to develop microbiome-based diagnostic and therapeutic approaches.
Dupilumab, a fully human monoclonal antibody that blocks the shared receptor component for interleukin-4 and interleukin-13, key central drivers of type 2 inflammation, has shown efficacy safety in phase 3 trial involving patients with chronic obstructive pulmonary disease (COPD) inflammation an elevated risk exacerbation. Whether findings would be confirmed second was unclear.
Abstract QRISK algorithms use data from millions of people to help clinicians identify individuals at high risk cardiovascular disease (CVD). Here, we derive and externally validate a new algorithm, which have named QR4, that incorporates novel factors estimate 10-year CVD separately for men women. Health 9.98 million 6.79 adults the United Kingdom were used derivation validation respectively. Cause-specific Cox models develop predict risk, performance QR4 was compared with version 3 QRISK,...
<h3>Background</h3> The genetic basis for developing asthma has been extensively studied. However, association studies to date have mostly focused on mild moderate disease and risk factors severe remain unclear. <h3>Objective</h3> To identify common variants affecting susceptibility asthma. <h3>Methods</h3> A genome-wide study was undertaken in 933 European ancestry individuals with based Global Initiative Asthma (GINA) criteria 3 or above 3346 clean controls. After standard quality control...
<i>Background:</i> Asthma and chronic obstructive pulmonary disease (COPD) display features of overlap in airway physiology inflammation. Whether inflammatory phenotypes describe similar mediator expression is unknown. <i>Objectives:</i> To explore the relationship inflammation cytokine chemokine asthma COPD. <i>Methods:</i> Subjects with COPD (n = 54 n 49) were studied. Clinical characteristics sputum collected at entry into study. A 2-step processing...
Bacteria are often isolated in stable chronic obstructive pulmonary disease (COPD). Whether fungi also commonly present and associated with clinical pathological features of is uncertain. We investigated the frequency filamentous fungal culture IgE sensitisation to Aspergillus fumigatus relationship outcomes COPD subjects. subjects were recruited enter a 1-year observational study. Assessments lung function, allergen testing sputum analysis for inflammation, bacteria fungus undertaken...