A5081966960- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Asthma and respiratory diseases
- Diagnosis and treatment of tuberculosis
- Respiratory and Cough-Related Research
- Long-Term Effects of COVID-19
- Infectious Diseases and Tuberculosis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- COVID-19 Clinical Research Studies
- Eosinophilic Esophagitis
- Pneumonia and Respiratory Infections
- COVID-19 and healthcare impacts
- Inhalation and Respiratory Drug Delivery
- SARS-CoV-2 and COVID-19 Research
- COVID-19 epidemiological studies
- Lung Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Pneumocystis jirovecii pneumonia detection and treatment
- Pediatric health and respiratory diseases
- Intensive Care Unit Cognitive Disorders
- Infection Control and Ventilation
- COVID-19 and Mental Health
- Chronic Disease Management Strategies
- Respiratory viral infections research
- Frailty in Older Adults
NIHR Leicester Biomedical Research Centre
2017-2025
University of Leicester
2016-2025
University Hospitals of Leicester NHS Trust
2013-2025
Glenfield Hospital
2012-2024
Imperial College London
2022-2024
National Institute for Health Research
2019-2023
University of Oxford
2023
Oxford Health NHS Foundation Trust
2023
Collaborative Group (United States)
2023
Restore America's Estuaries
2023
Rationale: Heterogeneity in asthma expression is multidimensional, including variability clinical, physiologic, and pathologic parameters. Classification requires consideration of these disparate domains a unified model.Objectives: To explore the application multivariate mathematical technique, k-means cluster analysis, for identifying distinct phenotypic groups.Methods: We performed analysis three independent populations. Clusters population managed primary care (n = 184) with predominantly...
Exacerbations of asthma are associated with substantial morbidity and mortality considerable use health care resources. Preventing exacerbations remains an important goal therapy. There is evidence that eosinophilic inflammation the airway risk exacerbations.We conducted a randomized, double-blind, placebo-controlled, parallel-group study 61 subjects who had refractory history recurrent severe exacerbations. Subjects received infusions either mepolizumab, anti-interleukin-5 monoclonal...
Exacerbations of chronic obstructive pulmonary disease (COPD) are heterogeneous with respect to inflammation and etiology.Investigate biomarker expression in COPD exacerbations identify biologic clusters determine biomarkers that recognize clinical exacerbation phenotypes, namely those associated bacteria, viruses, or eosinophilic airway inflammation.Patients were observed for 1 year at stable visits. Biomarkers measured sputum serum. Viruses selected bacteria assessed by polymerase chain...
The relationship between airway inflammation and obesity in severe asthma is poorly understood.We sought to determine the sputum mediator profiles distribution of eosinophilic people with asthma.Clinical parameters eight mediators were assessed 131 subjects from a single center categorized into lean, overweight, obese groups defined by their body mass index. In an independent group (n = 45) healthy control 19) was enumerated bronchial submucosa, blood, related index.Sputum IL-5 geometric...
Whole blood transcriptional signatures distinguishing active tuberculosis patients from asymptomatic latently infected individuals exist. Consensus has not been achieved regarding the optimal reduced gene sets as diagnostic biomarkers that also achieve discrimination other diseases. Here we show a signature of using RNA-Seq, confirming microarray results, discriminates and healthy individuals, validating this in an independent cohort. Using advanced modular approach, utilise information...
BackgroundTackling tuberculosis requires testing and treatment of latent in high-risk groups. The aim this study was to estimate the predictive values tuberculin skin test (TST) two interferon-γ release assays (IGRAs) for development active groups—ie, people recent contact with cases from high-burden countries.MethodIn prospective cohort study, we recruited participants 54 centres (eg, clinics, community settings) London, Birmingham, Leicester UK. Participants were eligible if they aged 16...
Tuberculosis remains a global health challenge, with early diagnosis key to its reduction. Face-mask sampling detects exhaled Mycobacterium tuberculosis. We aimed investigate bacillary output from patients pulmonary tuberculosis and assess the potential of face-mask as diagnostic method in active case-finding.
Blood transcriptomics have revealed major characteristics of the immune response in active TB, but signature early after infection is unknown. In a unique clinically and temporally well-defined cohort household contacts TB patients that progressed to we define minimal changes gene expression incipient increasing subclinical clinical TB. While with time, were highest at 30 d before diagnosis, heterogeneity published progressors as they bulk level individual progressors. signatures from during...
BackgroundFew studies have compared SARS-CoV-2 vaccine immunogenicity by ethnic group. We sought to establish whether cellular and humoral immune responses vaccination differ according ethnicity in UK Healthcare workers (HCWs).MethodsIn this cross-sectional analysis, we used baseline data from two immunological cohort conducted HCWs Leicester, UK. Blood samples were collected between March 3, September 16, 2021. excluded HCW who had not received doses of at the time sampling those...
BackgroundIncipient tuberculosis, a progressive state of Mycobacterium tuberculosis infection with an increased risk developing into disease, remains poorly characterised. Animal models suggest association bacteraemia. Circulating M DNA has previously been detected in pulmonary by use Actiphage, bacteriophage-based real-time PCR assay. We aimed to investigate whether serial [18F]fluorodeoxyglucose ([18F]FDG)-PET-CT could be used characterise the and trajectory incipient examine these PET-CT...
<h3>Background</h3> Severe asthma is a heterogeneous condition. Airway remodelling feature of severe and can be determined by the assessment high-resolution computed tomography (HRCT) scans. The aim this study was to assess whether airway restricted specific subphenotypes asthma. <h3>Methods</h3> A retrospective analysis performed HRCT scans from subjects who had attended single-centre clinic between 2003 2008. right upper lobe apical segmental bronchus (RB1) dimensions were measured...
Background Although tuberculosis is transmitted by the airborne route, direct information on natural output of bacilli into air source cases very limited. We sought to address this through sampling expelled aerosols in face masks that were subsequently analyzed for mycobacterial contamination. Methods In series 1, 17 smear microscopy positive patients wore standard surgical once or twice periods between 10 minutes and 5 hours; contamination was detected using a bacteriophage assay. 2, 19...