A5005082082- Tuberculosis Research and Epidemiology
- COVID-19 and Mental Health
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- COVID-19 and healthcare impacts
- Vaccine Coverage and Hesitancy
- Long-Term Effects of COVID-19
- COVID-19 epidemiological studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Migration, Health and Trauma
- Employment and Welfare Studies
- Infectious Diseases and Tuberculosis
- Diagnosis and treatment of tuberculosis
- Mycobacterium research and diagnosis
- Influenza Virus Research Studies
- Respiratory viral infections research
- Infection Control and Ventilation
- Global Health Workforce Issues
- Pneumonia and Respiratory Infections
- COVID-19 Pandemic Impacts
- Healthcare Systems and Challenges
- Healthcare professionals’ stress and burnout
- Intensive Care Unit Cognitive Disorders
- SARS-CoV-2 detection and testing
- COVID-19 Impact on Reproduction
University of Leicester
2016-2025
University Hospitals of Leicester NHS Trust
2016-2025
NIHR Leicester Biomedical Research Centre
2020-2025
National Institute for Health Research
2015-2025
NIHR Clinical Research Network
2020-2024
Leicester General Hospital
2022-2024
Imperial College London
2009-2024
NIHR Applied Research Collaboration West
2021-2024
University College London
2024
Joint Research Center
2023
The novel disease covid-19, caused by severe acute respiratory syndrome coronavirus SARS-CoV-2, is now a pandemic with devastating implications for populations, healthcare systems, and economies globally.Systematic reviews of ethnically homogenous cohorts from China suggest that the key risk factors hospital admission include age, male sex, comorbidities such as cardiovascular disease, hypertension, diabetes. 1The UK first country in covid-19 surge an diverse population can therefore...
The 2009 pandemic influenza A (H1N1) virus has emerged to cause the first of 21st century. Development effective vaccines is a public health priority.We conducted single-center study, involving 176 adults, 18 50 years age, test monovalent A/California/2009 surface-antigen vaccine, in both MF59-adjuvanted and nonadjuvanted forms. Subjects were randomly assigned receive two intramuscular injections vaccine containing 7.5 microg hemagglutinin on day 0 each arm or one injection other 7, 14, 21;...
BackgroundTackling tuberculosis requires testing and treatment of latent in high-risk groups. The aim this study was to estimate the predictive values tuberculin skin test (TST) two interferon-γ release assays (IGRAs) for development active groups—ie, people recent contact with cases from high-burden countries.MethodIn prospective cohort study, we recruited participants 54 centres (eg, clinics, community settings) London, Birmingham, Leicester UK. Participants were eligible if they aged 16...
Objectives To estimate the risk of Long COVID by socioeconomic deprivation and to further examine inequality sex occupation. Design We conducted a retrospective population-based cohort study using data from ONS COVID-19 Infection Survey between 26 April 2020 31 January 2022. This is largest nationally representative survey in UK with longitudinal on occupation, exposure COVID. Setting Community-based UK. Participants A total 201,799 participants aged 16 64 years severe acute respiratory...
BackgroundContinuing rises in tuberculosis notifications the UK are attributable to cases foreign-born immigrants. National guidance for immigrant screening is hampered by a lack of data about prevalence of, and risk factors for, latent infection We aimed determine immigrants define which groups should be screened quantify cost-effectiveness.MethodsIn our multicentre cohort study cost-effectiveness analysis we analysed demographic test results from three centres (from 2008 2010) that used...
Background. Oseltamivir, a specific influenza neuraminidase inhibitor, is an effective treatment for seasonal influenza. Emergence of drug-resistant viruses after has been reported, particularly in children Japan, where the dosing schedule different from that used throughout rest world. We investigated emergence infection treated with tiered weight-based regimen.
Tuberculosis remains a global health challenge, with early diagnosis key to its reduction. Face-mask sampling detects exhaled Mycobacterium tuberculosis. We aimed investigate bacillary output from patients pulmonary tuberculosis and assess the potential of face-mask as diagnostic method in active case-finding.
The aim of this study was to describe outcomes in hospitalised older people with different levels frailty and COVID-19 infection.
Background: Reports of ethnic inequalities in COVID-19 outcomes are conflicting and the reasons for any differences unclear. We investigated critical care admission patterns, need invasive mechanical ventilation (IMV), in-hospital mortality, among hospitalised patients with COVID-19. Methods: undertook a prospective cohort study which dedicated research staff recruited suspected/confirmed from 260 hospitals across England, Scotland Wales, collecting data directly records between 6th February...
Abstract In the COVID-19 pandemic, patients who are older and residents of long-term care facilities (LTCF) at greatest risk worse clinical outcomes. We reviewed discharge criteria for hospitalised from 10 countries with highest incidence cases as 26 July 2020. Five (Brazil, Mexico, Peru, Chile Iran) had no criteria; remaining five (USA, India, Russia, South Africa UK) guidelines large inter-country variability. India Russia recommend a clinically recovered patient two negative reverse...
Abstract Background Healthcare workers (HCWs) and ethnic minority groups are at increased risk of COVID-19 infection adverse outcome. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) vaccination is now available for frontline UK HCWs; however, demographic/occupational associations with vaccine uptake in this cohort unknown. We sought to establish these a large hospital workforce. Methods conducted cross-sectional surveillance examining amongst all staff University Hospitals...
Healthcare workers (HCWs) and ethnic minority groups are at increased risk of COVID-19 infection adverse outcomes. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination is now available for frontline UK HCWs; however, demographic/occupational associations with vaccine uptake in this cohort unknown. We sought to establish these a large hospital workforce.We conducted cross-sectional surveillance examining amongst all staff University Hospitals Leicester NHS Trust. examined...
Background Healthcare workers (HCWs), particularly those from ethnic minority groups, have been shown to be at disproportionately higher risk of infection with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) compared the general population. However, there is insufficient evidence on how demographic and occupational factors influence among HCWs. Methods findings We conducted a cross-sectional analysis using data baseline questionnaire United Kingdom Research study into Ethnicity...
The worldwide spread of the coronavirus disease 2019 (COVID-19) pandemic in early 2020 affected all major sectors, including higher education. measures to contain this deadly led closure colleges and universities across globe, disrupting lives millions students subjecting them a new world online learning. These sudden disturbances coupled with demands learning system experiences living through have placed additional strains on mental health university students. Research students’ health,...