Hayley Hardwick
A5023171939- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- COVID-19 and Mental Health
- SARS-CoV-2 and COVID-19 Research
- Intensive Care Unit Cognitive Disorders
- COVID-19 and healthcare impacts
- Sepsis Diagnosis and Treatment
- Herpesvirus Infections and Treatments
- COVID-19 Impact on Reproduction
- Kawasaki Disease and Coronary Complications
- Frailty in Older Adults
- Respiratory viral infections research
- Animal Virus Infections Studies
- SARS-CoV-2 detection and testing
- Poxvirus research and outbreaks
- Infectious Encephalopathies and Encephalitis
- Psychosomatic Disorders and Their Treatments
- Bacterial Infections and Vaccines
- Bacillus and Francisella bacterial research
- Respiratory Support and Mechanisms
- COVID-19 diagnosis using AI
- Pneumonia and Respiratory Infections
- interferon and immune responses
- Autoimmune Neurological Disorders and Treatments
- Pneumocystis jirovecii pneumonia detection and treatment
Health Protection Research Unit in Emerging and Zoonotic Infections at University of Liverpool
2020-2025
University of Liverpool
2020-2025
University of Leicester
2022-2024
NIHR Leicester Biomedical Research Centre
2022-2024
Aintree University Hospitals NHS Foundation Trust
2024
Glenfield Hospital
2023-2024
University of Oxford
2023
National Institute for Health Research
2022-2023
Newcastle University
2023
Newcastle upon Tyne Hospitals NHS Foundation Trust
2023
Abstract Objective To characterise the clinical features of patients admitted to hospital with coronavirus disease 2019 (covid-19) in United Kingdom during growth phase first wave this outbreak who were enrolled International Severe Acute Respiratory and emerging Infections Consortium (ISARIC) World Health Organization (WHO) Clinical Characterisation Protocol UK (CCP-UK) study, explore risk factors associated mortality hospital. Design Prospective observational cohort study rapid data...
Abstract Objective To develop and validate a pragmatic risk score to predict mortality in patients admitted hospital with coronavirus disease 2019 (covid-19). Design Prospective observational cohort study. Setting International Severe Acute Respiratory emerging Infections Consortium (ISARIC) World Health Organization (WHO) Clinical Characterisation Protocol UK (CCP-UK) study (performed by the ISARIC Coronavirus Consortium—ISARIC-4C) 260 hospitals across England, Scotland, Wales. Model...
Abstract Objective To characterise the clinical features of children and young people admitted to hospital with laboratory confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in UK explore factors associated admission critical care, mortality, development multisystem inflammatory adolescents temporarily related disease 2019 (covid-19) (MIS-C). Design Prospective observational cohort study rapid data gathering near real time analysis. Setting 260 hospitals...
Structured abstract Objective To characterize the clinical features of patients with severe COVID-19 in UK. Design Prospective observational cohort study rapid data gathering and near real-time analysis, using a pre-approved questionnaire adopted by WHO. Setting 166 UK hospitals between 6 th February 18 April 2020. Participants 16,749 people COVID-19. Interventions No interventions were performed, but consent samples taken for research purposes. Many participants co-enrolled other...
While it is now widely accepted that host inflammatory responses contribute to lung injury, the pathways drive severity and distinguish coronavirus disease 2019 (COVID-19) from other viral diseases remain poorly characterized. We analyzed plasma samples 471 hospitalized patients recruited through prospective multicenter ISARIC4C study 39 outpatients with mild disease, enabling extensive characterization of across a full spectrum COVID-19 severity. Progressive elevation levels numerous...
Background Immunocompromised patients may be at higher risk of mortality if hospitalised with Coronavirus Disease 2019 (COVID-19) compared immunocompetent patients. However, previous studies have been contradictory. We aimed to determine whether immunocompromised were greater in-hospital death and how this changed over the pandemic. Methods findings included > = 19 years symptomatic community-acquired COVID-19 recruited ISARIC WHO Clinical Characterisation Protocol UK prospective cohort...
Abstract Objectives To develop and validate a pragmatic risk score to predict mortality for patients admitted hospital with covid-19. Design Prospective observational cohort study: ISARIC WHO CCP-UK study (ISARIC Coronavirus Clinical Characterisation Consortium [4C]). Model training was performed on of recruited between 6 February 20 May 2020, validation conducted second 21 29 June 2020. Setting 260 hospitals across England, Scotland, Wales. Participants Adult (≥18 years) covid-19 at least...
Background: Reports of ethnic inequalities in COVID-19 outcomes are conflicting and the reasons for any differences unclear. We investigated critical care admission patterns, need invasive mechanical ventilation (IMV), in-hospital mortality, among hospitalised patients with COVID-19. Methods: undertook a prospective cohort study which dedicated research staff recruited suspected/confirmed from 260 hospitals across England, Scotland Wales, collecting data directly records between 6th February...
Introduction Very little is known about possible clinical sequelae that may persist after resolution of acute COVID-19. A recent longitudinal cohort from Italy including 143 patients followed up hospitalisation with COVID-19 reported 87% had at least one ongoing symptom 60-day follow-up. Early indications suggest need even more psychological support than typical intensive care unit patients. The assessment risk factors for longer term consequences requires a study linked to data on...
Abstract Background The mutational landscape of SARS-CoV-2 varies at the dominant viral genome sequence and minor genomic variant population. During COVID-19 pandemic, an early substitution in was D614G change spike protein, associated with increase transmissibility. Genomes are accompanied by a P323L polymerase (NSP12). However, is not thought to be under strong selective pressure. Results Investigation P323L/D614G substitutions population shows rapid emergence during containment phase...
Abstract Evidence before this study It is emerging that long-term symptoms are often present in people who have had acute COVID-19 disease. These affect a range of organ systems including respiratory, cardiovascular and neurological systems. not clear how many patients required hospitalisation develop these the impact they on quality life. We searched PubMed 24 th March 2021 using terms ‘COVID-19’, ‘long-Covid’, ‘long-term’ ‘outcomes’. This was supplemented by hand searching relevant...
BackgroundPatients with cancer are at greater risk of dying from COVID-19 than many other patient groups. However, how this evolved during the pandemic remains unclear. We aimed to determine, on basis UK national protocol, factors influencing hospital mortality could differentially affect patients undergoing treatment. also examined changes in and escalation care treatment first 2 years UK.MethodsWe conducted a prospective cohort study aged older 19 admitted 306 health-care facilities...
Purpose To prospectively validate two risk scores to predict mortality (4C Mortality) and in-hospital deterioration Deterioration) among adults hospitalised with COVID-19. Methods Prospective observational cohort study of (age ≥18 years) confirmed or highly suspected COVID-19 recruited into the International Severe Acute Respiratory emerging Infections Consortium (ISARIC) WHO Clinical Characterisation Protocol UK (CCP-UK) in 306 hospitals across England, Scotland Wales. Patients were between...
Background: Microbiological characterisation of co-infections and secondary infections in COVID-19 is lacking, while antimicrobial usage high. We aimed to describe microbiologically-confirmed co-/secondary infections, usage, hospitalised patients with COVID-19.Methods: Hospitalised England, Scotland, Wales confirmed/high likelihood SARS-CoV-2 infection were recruited the International Severe Acute Respiratory emerging Infections Consortium (ISARIC) WHO Clinical Characterisation Protocol UK...
Abstract Admission procalcitonin measurements and microbiology results were available for 1040 hospitalized adults with coronavirus disease 2019 (from 48 902 included in the International Severe Acute Respiratory Emerging Infections Consortium World Health Organization Clinical Characterisation Protocol UK study). Although was higher bacterial coinfection, this neither clinically significant (median [IQR], 0.33 [0.11–1.70] ng/mL vs 0.24 [0.10–0.90] ng/mL) nor diagnostically useful (area...
ObjectivesThe aims of this study were to assess aetiology and clinical characteristics in childhood meningitis, develop decision rules distinguish bacterial meningitis from other similar syndromes.MethodsChildren aged <16 years hospitalised with suspected meningitis/encephalitis included, prospectively recruited at 31 UK hospitals. Meningitis was defined as identification bacteria/viruses cerebrospinal fluid (CSF) and/or a raised CSF white blood cell count. New developed viral those...
Abstract Objectives Evaluation of diagnostic accuracy two point-of-care (POC) molecular tests for the detection monkeypox virus (MPXV): Xpert® Mpox (Cepheid, Inc., USA) and STANDARD™ M10 MPX/OPX (SD Biosensor, Korea). Methods Diagnostic both platforms was evaluated using 53 upper-respiratory swabs (URS) 32 skin lesions (SS) collected from mpox COVID-19 patients in UK against Sansure (Sansure Biotech Inc.) CDC reference qPCR tests. The analytical sensitivity assessed a viral isolate lineage...
Abstract Background We hypothesised that the clinical characteristics of hospitalised children and young people (CYP) with SARS-CoV-2 in UK second wave (W2) would differ from first (W1) due to alpha variant (B.1.1.7), school reopening relaxation shielding. Methods Prospective multicentre observational cohort study patients <19 years between 17/01/20 31/01/21. Clinical were compared W1 W2 (W1 = 17/01/20-31/07/20,W2 01/08/20-31/01/21). Results 2044 CYP < 19 187 hospitals. 427/2044...
The SARS-CoV-2 pandemic enables the analysis of immune responses induced against a novel coronavirus infecting immunologically naïve individuals. This provides an opportunity for and associations with age, sex disease severity. Here we measured array solid-phase binding antibody viral neutralising Ab (nAb) in participants (n=337) ISARIC4C cohort characterised their correlation peak severity during acute infection early convalescence. Overall, Double Antigen Binding Assay (DABA) to receptor...
Encephalitis, brain inflammation and swelling, most often caused by an infection or the body's immune defences, can have devastating consequences, especially if diagnosed late. We looked for clinical predictors of different types encephalitis to help clinicians consider earlier treatment.We conducted a multicentre prospective observational cohort study (ENCEPH-UK) adults (> 16 years) with suspected at 31 UK hospitals. evaluated features investigated infectious autoimmune causes.341 patients...