A5057187315- Peripheral Neuropathies and Disorders
- Multiple Sclerosis Research Studies
- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- MRI in cancer diagnosis
- Systemic Lupus Erythematosus Research
- Autoimmune Neurological Disorders and Treatments
- Mosquito-borne diseases and control
- Neurological disorders and treatments
- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Spinal Dysraphism and Malformations
- Botulinum Toxin and Related Neurological Disorders
- Intracranial Aneurysms: Treatment and Complications
- Advanced Neuroimaging Techniques and Applications
- Infectious Encephalopathies and Encephalitis
- Medical Imaging Techniques and Applications
- Spine and Intervertebral Disc Pathology
- Herpesvirus Infections and Treatments
- Malaria Research and Control
- Meningioma and schwannoma management
- Spinal Fractures and Fixation Techniques
- Cardiac tumors and thrombi
- Pituitary Gland Disorders and Treatments
- Genetic Neurodegenerative Diseases
University of Liverpool
2016-2025
Walton Centre
2016-2025
University of Washington
2018
Emory University
2018
Johns Hopkins University
2018
New York University
2018
Mayo Clinic
2018
Royal Victoria Infirmary
2018
Royal College of Physicians
2004
Royal College of Physicians and Surgeons of Glasgow
2004
<h3>Importance</h3> Antibodies to myelin oligodendrocyte glycoprotein IgG (MOG-IgG) are increasingly detected in patients with non–multiple sclerosis–related demyelination, some of whom manifest a neuromyelitis optica (NMO) phenotype. Cortical involvement, encephalopathy, and seizures rare aquaporin 4 antibody (AQP4-IgG)–related NMO the white European population. However, authors encountered several associated MOG-IgG disease. <h3>Objective</h3> To compare incidence encephalitis-like...
Antibodies to myelin oligodendrocyte glycoprotein (MOG-IgG) have been described in patients with neuromyelitis optica spectrum disorders (NMOSD) without aquaporin-4 antibodies (AQP4-IgG). We aimed identify the proportion of AQP4-IgG-negative NMOSD who are seropositive for MOG-IgG. In a cross sectional study, we reviewed all seen National NMO clinic over last 4 years (after availability MOG-IgG testing), including clinical information, MRI, and antibody tests. 261 unique were identified. 132...
During 2015-16 Brazil experienced the largest epidemic of Zika virus ever reported. This arthropod-borne (arbovirus) has been linked to Guillain-Barré syndrome (GBS) in adults but other neurological associations are uncertain. Chikungunya caused outbreaks since 2014 associated disease rarely reported here. We investigated with acute disorders for Zika, chikungunya and dengue, another arbovirus circulating Brazil.We studied who had developed a new condition following suspected infection...
BackgroundSince 2015, the arthropod-borne viruses (arboviruses) Zika and chikungunya have spread across Americas causing outbreaks, accompanied by increases in immune-mediated infectious neurological disease. The spectrum of manifestations linked to these viruses, importance dual infection, are not known fully. We aimed investigate whether presentations differed according infecting arbovirus, patients with infection had a different disease or severity.MethodsWe report prospective...
Diffusion-weighted MRI (DWI) has been used in neurosurgical practice mainly to distinguish cerebral metastases from abscess and glioma. There is evidence other solid organ cancers that DWI may be as a biomarker of prognosis treatment response. We therefore investigated characteristics their peritumoral region recorded pre-operatively related these patient outcomes.Retrospective analysis 76 cases operated upon at single institution with performed 1.5T. Maps apparent diffusion coefficient...
Progressive multifocal leukoencephalopathy (PML) has not been reported in pediatric neuromyelitis optica spectrum disorder (NMOSD) and rarely described children. To report a case of PML childhood-onset NMOSD. A single retrospective report. Nine years after diagnosis aquaporin-4 antibody positive NMOSD, 17-year-old boy treated with rituximab presented painless right visual loss over 6 weeks coinciding CD19 repopulation. Acute relapse treatment was given but he continued to deteriorate, JC...
Abstract Brain metastases are common and usually detected by MRI. Diffusion tensor imaging (DTI) is a derivative MRI technique that can detect disruption of white matter tracts in the brain. We have matched preoperative DTI with image-guided sampling brain–tumor interface 26 patients during resection brain metastasis assessed mean diffusivity fractional anisotropy (FA). The tissue samples were analyzed for vascularity, inflammatory cell infiltration, growth pattern, tumor expression proteins...
Purpose: To compare clinical and radiological outcomes between short (SSPF) long-segment (LSPF) posterior fixation for thoracolumbar junction (TLJ) fractures.Materials methods: Retrospective review of adult patients, with single-level, TLJ (T11-L2) fractures, treated 2007 2014 at a regional spinal centre. SSPF LSPF were defined as transpedicular screw one two levels above below the fractured vertebra, respectively. Construct failure was instrument breakage or pull-out requiring operative...
Objectives Our aim was to compare neuropsychological and psychiatric outcomes across three encephalitis aetiological groups: Herpes simplex virus (HSV), other infections or autoimmune causes (Other), of unknown cause (Unknown). Methods Patients recruited from NHS hospitals underwent assessment in the short-term (4 months post-discharge), medium-term (9–12 after first assessment), long-term (>1-year). Healthy control subjects were general population completed same assessments. Results with...
A retrospective review was made to assess the accuracy of four dimensional CT angiogram (4D-CTA) in diagnosis arteriovenous malformations (AVM) and dural fistulas (DAVF), with catheter-based digital-subtraction (DSA) being gold standard. 33 pairs investigations (DSA 4D-CTA) were performed primarily for suspicion AVM/DAVF. Based on blinded reports, sensitivity specificity detection AVM/DAVF 77% (95% CI: 46 - 95%) 100% 83 100%) respectively. Positive predictive value 69 negative 87% 66-97%)....
Background: Isolated first episodes of longitudinally extensive transverse myelitis (LETM) have typically been associated with neuromyelitis optica spectrum disorder (NMOSD) or myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD). However, in some cases, serological testing and screening for other aetiologies are negative, a condition referred to as double seronegative (dsLETM). Objective: The objective this study was evaluate comparative outcomes dsLETM, MOGAD-LETM...
Encephalitis, brain inflammation and swelling, most often caused by an infection or the body's immune defences, can have devastating consequences, especially if diagnosed late. We looked for clinical predictors of different types encephalitis to help clinicians consider earlier treatment.We conducted a multicentre prospective observational cohort study (ENCEPH-UK) adults (> 16 years) with suspected at 31 UK hospitals. evaluated features investigated infectious autoimmune causes.341 patients...
Essential tremor (ET) and dystonic (DT) are movement disorders that cause debilitating symptoms, significantly impacting daily activities quality of life. A poor understanding their pathophysiology, as well the mediators clinical outcomes following deep brain stimulation (DBS), highlights need for biomarkers to accurately characterise optimally treat patients.
The optimal diagnostic evaluation for patients with angiographically negative subarachnoid hemorrhage (AN-SAH) remains controversial.To assess the utilization rate and yield of imaging tests routinely obtained in identifying a structural cause AN-SAH.In this retrospective multicenter study, consecutive adult admitted nontraumatic, AN-SAH between 01/2010 12/2015 were included. Patients intraparenchymal, subdural, or epidural hematomas addition to SAH excluded. Outcomes studied included rate,...
A 23-year-old Caucasian woman developed simultaneous onset longitudinally extensive transverse myelitis (LETM; figure, A.a) and left optic neuritis. She had no significant neurologic history, but her brother MS. At nadir, she Medical Research Council grade 2/5 power in the lower limbs a sensory level at T4. MRI of brain identified lesions within right middle cerebellar peduncle (figure, A.b) adjacent to posterior horn lateral ventricle A.c). Oligoclonal bands were present CSF, serum...
Cerebral CT Venography Using a 320-MDCT Scanner With Time-Density Curve Technique and Low Volume of Contrast Agent: Comparison Fixed Time-Delay TechniqueShubhabrata Biswas1, Arun Chandran1, Sue Roughley1, Maneesh Bhojak1 Kumar Das1Audio Available | Share