A5078744146- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Acute Ischemic Stroke Management
- Pharmacological Effects and Toxicity Studies
- Epilepsy research and treatment
- Myasthenia Gravis and Thymoma
- Cerebrovascular and Carotid Artery Diseases
- Parkinson's Disease and Spinal Disorders
- Cancer Diagnosis and Treatment
- Drug Transport and Resistance Mechanisms
- Polyomavirus and related diseases
- Cytokine Signaling Pathways and Interactions
- Neuroscience and Neuropharmacology Research
- Protein Tyrosine Phosphatases
- Autoimmune Neurological Disorders and Treatments
- Systemic Lupus Erythematosus Research
- Inflammatory Myopathies and Dermatomyositis
- Long-Term Effects of COVID-19
- Otitis Media and Relapsing Polychondritis
- Intracerebral and Subarachnoid Hemorrhage Research
- Hereditary Neurological Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer-related cognitive impairment studies
- Lymphadenopathy Diagnosis and Analysis
- Chemical Synthesis and Analysis
Alfred Health
2021-2025
Monash University
2023-2025
Walton Centre
2024-2025
University of Liverpool
2024-2025
Eastern Health
2022-2023
Ballarat Health Services
2019-2020
We sought to identify an optimal oral corticosteroid regimen at the onset of myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), which would delay time first relapse while minimising cumulative exposure.
Multiple sclerosis (MS) is a chronic inflammatory demyelinating and degenerative disease of the central nervous system. There were 33 335 people with MS in Australia 2021 2917 New Zealand 2006 prevalence incidence are increasing time. Although new treatments have substantially improved outcomes recent decades, treatment landscape has become increasingly complex due to expanding number disease-modifying therapies (DMTs) associated safety considerations. A total 80 consensus recommendations...
In aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder (AQP4-IgG NMOSD), disability accrual is mostly attributed to relapses. This study aimed assess the prevalence of progression independent relapse activity (PIRA) and relapse-associated worsening (RAW) in AQP4-IgG NMOSD. was a retrospective cohort patients with NMOSD enrolled MSBase international data registry. Patients required minimum 3 recorded Expanded Disability Status Scale (EDSS) scores: baseline, event, 6-month...
Multiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disease of the central nervous system with rapidly evolving treatment options strategies. An iterative modified Delphi process was used to develop 80 consensus recommendations for management MS in Australia New Zealand. Part 1 these guidelines includes related selection initial disease-modifying therapy (DMT) MS, assessments before commencing DMT, monitoring activity on switching discontinuing DMT. This article, 2,...
ABSTRACT Background Most patients with aquaporin‐4 antibody‐positive neuromyelitis optica spectrum disorder (AQP4‐IgG NMOSD) require life‐long immunosuppression to prevent relapses. Patients who are untreated or undergo de‐escalation of therapy typically experience severe disabling We present a series who, despite not receiving immunosuppression, developed minimal disability. Methods Case from UK national NMOSD referral centre. defined benign disease as an estimated disability status scale...
Progressive multifocal leukoencephalopathy (PML) has not been reported in pediatric neuromyelitis optica spectrum disorder (NMOSD) and rarely described children. To report a case of PML childhood-onset NMOSD. A single retrospective report. Nine years after diagnosis aquaporin-4 antibody positive NMOSD, 17-year-old boy treated with rituximab presented painless right visual loss over 6 weeks coinciding CD19 repopulation. Acute relapse treatment was given but he continued to deteriorate, JC...
More than half of adults with epilepsy undergoing resective surgery achieve long-term seizure freedom and might consider withdrawing antiseizure medications. We aimed to identify predictors recurrence after starting postoperative medication withdrawal develop validate predictive models. performed an international multicentre observational cohort study in nine tertiary referral centres. included 850 who started following were free seizures other focal non-motor aware before withdrawal....
Background Neuromyelitis optica spectrum disorder (NMOSD) can be categorised into aquaporin-4 antibody (AQP4-IgG) NMOSD or seronegative NMOSD. While our knowledge of AQP4-IgG has evolved significantly in the past decade, remains less understood. This study aimed to evaluate predictors relapses and treatment responses Methods was a multicentre, international, retrospective cohort using MSBase registry. Recurrent relapse risk assessed an Andersen-Gill model first evaluated Cox proportional...
Abstract Background There is no universally accepted age cut‐off for defining young strokes. Aims We aimed to determine, based on the profile of stroke patients in our regional centre, an appropriate Methods A retrospective analysis all ischaemic admitted centre from 2015 2017. identified 391 patients; 30 between ages ≤50, 40 51–60 inclusive and 321 ≥ 61 years age. collected data demographic profiles, risk factors classification using Trial Org 10 172 Acute Stroke Treatment criteria. Results...
Stroke and diabetes mellitus (DM) are significant interrelated healthcare issues but there is a dearth of data on the prevalence DM among Australia's regional stroke population.We aimed to determine in patients at large centre, including subanalyses subtypes, glycaemic control renal function ischaemic (IS).We conducted retrospective analysis all (n = 323) with IS or transient attack (TIA) admitted Ballarat Base Hospital from January 2015 December 2016. Demographic data, cardiovascular risk...
<h3>Background</h3> IMPP have myopathological features that are distinct from dermatomyositis (DM) and usually associated with extramuscular manifestations.<sup>1 2</sup> There is also some evidence the pathophysiology in Anti-Mi-2 DM may be more similar to phenotypes than other myositis antibodies.<sup>3</sup> <h3>Methods/Results</h3> We present a case of 71-year-old woman six-month history progressive muscle weakness. Her father had Paget's disease bone Dementia his 70's. Examination...
To investigate the predictors of relapses in seropositive and seronegative neuromyelitis optica spectrum disorder (NMOSD).
<h3>Introduction</h3> 40–60% of people experiencing a first clinical attack myelin oligodendrocyte glycoprotein antibody associated disease (MOGAD) will develop relapsing (R-MOGAD). The accurate risk prediction R-MOGAD is challenging. <h3>Objective</h3> To study the value combined predictive model for developing using features described by prior research studies. <h3>Methods</h3> A multivariate binary logistic regression was applied on retrospective dataset patients with MOGAD from...
Abstract More than half of adults with epilepsy undergoing resective surgery achieve long-term seizure freedom and might consider withdrawing antiseizure medications (ASMs). We aimed to identify predictors recurrence after starting postoperative ASM withdrawal develop validate predictive models. performed an international multicentre observational cohort study in nine tertiary referral centres. included 850 who started following were free seizures other focal non-motor aware (auras) before...
Although there is an established association between cancer and stroke, the role of malignancy as a causative agent or comorbidity not always clear. Moreover, are no guidelines on acute treatment cancer-associated stroke optimal anticoagulation. This case report illustrates significance these practice gaps. A 62-year-old Caucasian woman presented to our institute with neurological deficits was found have occluded left middle cerebral artery computed tomographic angiogram. She administered...