A5071570937- Multiple Sclerosis Research Studies
- Systemic Lupus Erythematosus Research
- Peripheral Neuropathies and Disorders
- Immunotherapy and Immune Responses
- Functional Brain Connectivity Studies
- Infectious Encephalopathies and Encephalitis
- Systemic Sclerosis and Related Diseases
- Advanced Neuroimaging Techniques and Applications
- Autoimmune Neurological Disorders and Treatments
- Neurological and metabolic disorders
- Polyomavirus and related diseases
- T-cell and B-cell Immunology
- Immune Response and Inflammation
- Cannabis and Cannabinoid Research
- Alcoholism and Thiamine Deficiency
- Neuroinflammation and Neurodegeneration Mechanisms
- Long-Term Effects of COVID-19
- Myasthenia Gravis and Thymoma
- Cytokine Signaling Pathways and Interactions
- Parasites and Host Interactions
- Herpesvirus Infections and Treatments
- Gut microbiota and health
- Neuroscience and Neuropharmacology Research
- Tryptophan and brain disorders
- Liver Disease Diagnosis and Treatment
Nottingham University Hospitals NHS Trust
2014-2025
University of Nottingham
2016-2025
Queen's Medical Centre
2016-2025
Nottingham Biomedical Research Centre
2023-2025
National Institute for Health Research
2025
National Health Service
2020-2022
Spitalul Clinic Colentina
2005-2020
Carol Davila University of Medicine and Pharmacy
2011-2020
Avila University
2017
Versus Arthritis
2016
Although Wernicke encephalopathy (WE) is a preventable and treatable disease it still often remains undiagnosed during life.To create practical guidelines for diagnosis, management prevention of the disease.We searched MEDLINE, EMBASE, LILACS, Cochrane Library.1 The clinical diagnosis WE should take into account different presentations signs between alcoholics non (Recommendation Level C); although prevalence higher in alcoholics, be suspected all conditions which could lead to thiamine...
Background: Paraneoplastic neurological syndromes (PNS) almost invariably predate detection of the malignancy. Screening for tumours is important in PNS as tumour directly affects prognosis and treatment should be performed soon possible. Objectives: An overview screening related to classical given. Small cell lung cancer, thymoma, breast ovarian carcinoma teratoma testicular are described relation paraneoplastic limbic encephalitis, subacute sensory neuronopathy, autonomic neuropathy,...
Although SARS-CoV-2 vaccines are very safe, we report 4 cases of the bifacial weakness with paresthesias variant Guillain-Barré syndrome (GBS) occurring within 3 weeks vaccination Oxford-AstraZeneca vaccine. This rare neurological has previously been reported in association infection itself. Our were given either intravenous immunoglobulin, oral steroids, or no treatment. We suggest vigilance for GBS following and that postvaccination surveillance programs ensure robust data capture this...
Symptomatic intracranial atherothrombotic stenoses (ICAS) are associated with high rates of cerebrovascular ischemic events.To conduct a prospective multicenter study to evaluate the natural history ICAS and, in those patients refractory medical treatment, outcomes angioplasty.Patients aged 18 80 were enrolled symptoms attributed single > or =50%. Optimal therapy vascular risk factors and preventive antithrombotic at discretion local investigator. Patients eligible for angioplasty after...
To investigate the regulation of cannabinoid receptors CB1 and CB2 on immune cells by pro-inflammatory cytokines its potential relevance to inflammatory neurological disease, multiple sclerosis (MS). signalling may be anti-inflammatory neuroprotective in neuroinflammatory diseases. Cannabinoids can suppress but effects these expression function are unknown.Immune from peripheral blood were obtained healthy volunteers patients with MS. Expression mRNA whole cells, mononuclear (PBMC) T was...
To determine the safety, pharmacokinetics (PK), and immunogenicity of recombinant human monoclonal antibody MOR103 to granulocyte-macrophage colony-stimulating factor (GM-CSF) in patients with multiple sclerosis (MS) clinical or MRI activity.In this 20-week, randomized, double-blind, placebo-controlled phase 1b dose-escalation trial (registration number NCT01517282), adults relapsing-remitting MS (RRMS) secondary progressive (SPMS) received an IV infusion placebo (n = 6) 0.5 8), 1.0 2.0 9)...
Studies suggest gut worms induce immune responses that can protect against multiple sclerosis (MS). To our knowledge, there are no controlled treatment trials with helminth in MS.To determine whether hookworm has effects on magnetic resonance imaging (MRI) activity and T regulatory cells relapsing MS.This 9-month double-blind, randomized, placebo-controlled trial was conducted between September 2012 March 2016 a modified intention-to-treat population (the data were analyzed June 2018) at the...
There is increasing evidence suggesting that Epstein-Barr virus infection a causative factor of multiple sclerosis (MS). (EBV) human herpesvirus, Human Gammaherpesvirus 4. EBV shows two peaks: firstly, during early childhood and, secondly the teenage years. Approximately, 90-95% adults have been infected with and for many this will subclinical event. can be associated significant morbidity mortality; example, primary in older children or leading cause infectious mononucleosis (IM). A...
This study assessed feasibility, safety, and tolerability of accelerated intermittent theta burst stimulation (aiTBS) with effective connectivity-guidance targeting the left dorsolateral prefrontal cortex (lDLPFC) from right anterior insular (rAI) in chronic knee osteoarthritis pain. The BoostCPM clinical trial (ISRCTN15404076) was a randomized, sham-controlled, single-blind, parallel-group pilot patients mild-moderate Participants were assigned 2:1 (active: sham) aiTBS for 4 consecutive...
Multiple sclerosis (MS) is an immune-mediated inflammatory demyelinating disease of the central nervous system. It was previously shown that toll-like receptor (TLR)-2 signaling plays a key role in murine experimental autoimmune encephalomyelitis (EAE) model MS, and TLR2-stimulation regulatory T cells (Tregs) promotes their conversion to helper 17 (Th17) cells. Here, we sought potential sources TLR2 stimulation evidence activity MS patient clinical samples. Soluble (sTLR2) found be...
Smoking is associated with a more severe disease course in people multiple sclerosis (MS). The magnitude of effect smoking cessation on MS progression unknown. aim this study was to quantify the impact reaching disability milestones.This cross-sectional retrospective reports. A comprehensive questionnaire sent 1270 patients registered between 1994 and 2013 Nottingham University Hospital Clinics database. Demographic clinical data were extracted from Cox proportional hazard regression used...
Abstract Background Helminth-associated changes in gut microbiota composition have been hypothesised to contribute the immune-suppressive properties of parasitic worms. Multiple sclerosis is an immune-mediated autoimmune disease central nervous system whose pathophysiology has linked imbalances microbial communities. Results In present study, we investigated, for first time, qualitative and quantitative faecal bacterial human volunteers with remitting multiple (RMS) prior following...