A5090004519- Cytomegalovirus and herpesvirus research
- Respiratory viral infections research
- Viral Infections and Immunology Research
- Herpesvirus Infections and Treatments
- Neonatal and Maternal Infections
- Parvovirus B19 Infection Studies
- Neonatal Health and Biochemistry
- Bacterial Infections and Vaccines
- Viral gastroenteritis research and epidemiology
- Pneumonia and Respiratory Infections
- COVID-19 and healthcare impacts
- Neonatal Respiratory Health Research
- Infectious Diseases and Tuberculosis
- Autoimmune and Inflammatory Disorders Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Mycobacterium research and diagnosis
- Bacterial Identification and Susceptibility Testing
- Emergency and Acute Care Studies
- Kawasaki Disease and Coronary Complications
- Antibiotic Resistance in Bacteria
- Infectious Encephalopathies and Encephalitis
- Misinformation and Its Impacts
- Hearing, Cochlea, Tinnitus, Genetics
- Orthopedic Infections and Treatments
- Vaccine Coverage and Hesitancy
Great Ormond Street Hospital
2022-2025
University College London
2018-2025
University of Oxford
2018-2025
Great Ormond Street Hospital for Children NHS Foundation Trust
2022-2024
Oxford BioMedica (United Kingdom)
2018-2024
John Radcliffe Hospital
2017-2023
Royal Children's Hospital
2020-2022
Oxford University Hospitals NHS Trust
2018-2022
Institut de Recherche Vaccinale
2021
Wexham Park Hospital
2020
Abstract Objective To assess the impact of covid-19 pandemic on hospital admission rates and mortality outcomes for childhood respiratory infections, severe invasive vaccine preventable disease in England. Design Population based observational study 19 common respiratory, invasive, comparing before after onset Setting Hospital data from every NHS England 1 March 2017 to 30 June 2021 with record linkage national data. Children aged 0-14 years admitted an a selected infection 2021. Main...
Abstract Preterm birth (PTB) is the leading cause of infant mortality worldwide. Changes in PTB rates, ranging from −90% to +30%, were reported many countries following early COVID-19 pandemic response measures (‘lockdowns’). It unclear whether this variation reflects real differences lockdown impacts, or perhaps stillbirth rates and/or study designs. Here we present interrupted time series and meta-analyses using harmonized data 52 million births 26 countries, 18 which had representative...
<h3>Background</h3> Congenital cytomegalovirus (cCMV) is the most common non-genetic cause of sensorineural hearing loss (SNHL) in children. Ganciclovir has been shown to prevent continued deterioration children with symptomatic cCMV, but some cCMV-related SNHL are unidentified neonatal treatment period. Neonatal cCMV screening provides an opportunity identify infants who might benefit from early treatment. <h3>Objectives</h3> To assess feasibility (ability take samples before 3 weeks age...
This study aimed to prospectively collect detailed clinical information for all enterovirus (EV) and human parechovirus (HPeV) meningitis cases in infants aged <90 days the UK Ireland.Prospective, active national surveillance during July 2014 2015 through British Paediatric Surveillance Unit. Reporting paediatricians completed questionnaires requesting on presentation, investigations, management outcomes at hospital discharge after 12 months.To describe burden of EV HPeV days.During 13-month...
<h3>Background</h3> Congenital cytomegalovirus (cCMV) is an important cause of childhood deafness, which modifiable if diagnosed within the first month life. Targeted screening infants who do not pass their newborn hearing tests in England a feasible approach to identify and treat cases improve outcome. <h3>Aims</h3> To conduct cost analysis targeted subsequent treatment for cCMV-related sensorineural loss (SNHL) an, otherwise, asymptomatic infant, from perspective UK National Health Service...
To The Editors: Pediatric Emergency Department (ED) attendances have fallen markedly in countries worst-affected by the COVID-19 pandemic, but reasons not been fully elucidated.1,2 Anecdotes exist of late presentations with serious non-COVID-19 illness, problem has closely studied. We aimed to measure and characterize pandemic's impact on other infection-related admissions (non-COVID-19) at an Australian tertiary pediatric hospital during most restrictive period interventions (April 1–May...
Background: Multiplex polymerase chain reaction assays have the potential to reduce antibiotic use and shorten length of inpatient stay in children with suspected central nervous system infection by obtaining an early microbiological diagnosis. The clinical impact implementation BioFire FilmArray Meningitis/Encephalitis Panel on management childhood meningitis was evaluated at John Radcliffe Hospital Oxford Children’s Health Ireland Temple Street Dublin. Methods: Children who had lumbar...
The COVID-19 pandemic has highlighted how ethnic minority groups are disproportionally affected by health crises and the potential for community engagement to provide equitable public information services. Policymakers, practitioners, academics have presented as a way improve access uptake of services, including vaccination, but role members promotion is rarely questioned. We examine 'community vaccine champions', who been acting advocates, promoting among vaccination in different...
BackgroundGentamicin and vancomycin are commonly used in neonatal units for the treatment of life-threatening infections. This study aimed to describe dosage regimen approach therapeutic drug monitoring (TDM) both antibiotics that participate a UK network.
Bacterial conjugate vaccines have dramatically changed the epidemiology of childhood meningitis; viral causes are increasingly predominant, but current UK is unknown. This prospective study recruited children under 16 years age admitted to 3 hospitals with suspected meningitis. 70/388 had meningitis—13 bacterial, 26 and 29 no pathogen identified. Group B Streptococcus was most common bacterial pathogen. Infants months meningitis were more likely a reduced Glasgow Coma Score respiratory...
Background: Children are largely unaffected following Sars-CoV-2 infection with low rates of significant disease and the inflammatory syndrome MIS-C. However, lives children have been substantially disrupted by pandemic through physical distancing measures impact on health systems economies. In this study, COVID-19 hospital admissions for childhood respiratory infections, severe invasive vaccine preventable in England was assessed along associated mortality outcomes.Methods: population-based...
ObjectivesThe aims of this study were to assess aetiology and clinical characteristics in childhood meningitis, develop decision rules distinguish bacterial meningitis from other similar syndromes.MethodsChildren aged <16 years hospitalised with suspected meningitis/encephalitis included, prospectively recruited at 31 UK hospitals. Meningitis was defined as identification bacteria/viruses cerebrospinal fluid (CSF) and/or a raised CSF white blood cell count. New developed viral those...
In the conjugate vaccine era, viruses are most common cause of meningitis. Here, we evaluated epidemiological trends in laboratory-confirmed viral meningitis across all age-groups over an 11-year period England.