A5031027805- Tuberculosis Research and Epidemiology
- Streptococcal Infections and Treatments
- Pneumonia and Respiratory Infections
- Respiratory viral infections research
- Influenza Virus Research Studies
- SARS-CoV-2 and COVID-19 Research
- Infectious Diseases and Tuberculosis
- Emergency and Acute Care Studies
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Bacterial Infections and Vaccines
- Pneumocystis jirovecii pneumonia detection and treatment
- Antimicrobial Resistance in Staphylococcus
- Otolaryngology and Infectious Diseases
- Kawasaki Disease and Coronary Complications
- Viral Infections and Outbreaks Research
- Viral Infections and Vectors
- COVID-19 Impact on Reproduction
- Herpesvirus Infections and Treatments
- Ultrasound in Clinical Applications
- Neonatal Respiratory Health Research
- Cytomegalovirus and herpesvirus research
- Viral Infections and Immunology Research
- Fungal Infections and Studies
- Vasculitis and related conditions
Murdoch Children's Research Institute
2021-2025
Royal Children's Hospital
2020-2025
The University of Melbourne
2022-2024
Royal Ottawa Mental Health Centre
2021
General Department of Preventive Medicine
2021
Imperial College Healthcare NHS Trust
2019
Yara (Norway)
2016
BackgroundIncreases in invasive group A streptococcal disease (iGAS) have recently been reported multiple countries the northern hemisphere, occurring during, and outside of, typical spring peaks. We report epidemiology of iGAS among children Australia from 1 July 2018 to 31 December 2022.MethodsThe Paediatric Active Enhanced Disease Surveillance (PAEDS) Network prospectively collected patient notifications for young people aged less than 18 years admitted five major Australian paediatric...
Abstract The COVID-19 pandemic and relevant non-pharmaceutical interventions (NPIs) interrupted the circulation of common respiratory viruses. These viruses demonstrated an unprecedented asynchronous resurgence as NPIs were relaxed. We compiled a global dataset from systematic review, online surveillance reports unpublished data Respiratory Virus Global Epidemiology Network, encompassing 92 sites. compared timings within each site synthesised differences in across sites, using generalised...
To The Editors: Pediatric Emergency Department (ED) attendances have fallen markedly in countries worst-affected by the COVID-19 pandemic, but reasons not been fully elucidated.1,2 Anecdotes exist of late presentations with serious non-COVID-19 illness, problem has closely studied. We aimed to measure and characterize pandemic's impact on other infection-related admissions (non-COVID-19) at an Australian tertiary pediatric hospital during most restrictive period interventions (April 1–May...
To describe the epidemiology of respiratory viruses in children before and during 2020 SARS-CoV-2 pandemic relationship to public health measures instituted by Victorian government.Retrospective audit at a tertiary paediatric hospital Melbourne from January 2015 up week 47, under 18 years age. The proportion positive cases weeks 1-47 2015-2019 (period 1) were compared 1-47, 2), reviewed context restrictions Victoria.An annual average 4636 tests performed period 1 3659 2. Proportions...
A 7-year-old girl with tuberculous (TB) meningitis developed optochiasmatic arachnoiditis, a vision-threatening paradoxical reaction, after starting TB treatment including adjunctive steroid therapy. She was treated infliximab complete recovery. This is the first report of use tissue necrosis factor α inhibitor for severe reaction in child.
Paradoxical reactions in central nervous system tuberculosis (CNS-TB) are associated with significant morbidity and mortality. We describe 4 HIV-uninfected children treated for CNS-TB severe paradoxical unresponsive to corticosteroids. All made recovery after treatment infliximab, highlighting the safety effectiveness of infliximab this complication, need prospective trials.
We report a child from Southern Australia (New South Wales) who presented during La Niña event with encephalopathy and acute flaccid paralysis. Magnetic resonance imaging suggested Japanese encephalitis (JE). Steroids intravenous immunoglobulin did not improve symptoms. Therapeutic plasma exchange (TPE) resulted in rapid improvement tracheostomy decannulation. Our case illustrates the complex pathophysiology of JE, its' geographic expansion into potential use TPE for neuroinflammatory sequelae.
Abstract Background Chest x-ray (CXR) is commonly used (when available) to support clinical management decisions for child pneumonia and provide a reference standard diagnosis in research studies. However, its diagnostic technical limitations both purposes are well recognised. Recent evidence suggests that lung ultrasound (LUS) may have utility pneumonia. This systematic scoping review of on the CXR LUS severe childhood aims inform pragmatic guidelines low- middle-income countries (LMICs)...
Current guidelines for severe herpes simplex virus infection recommend 21 days of intravenous therapy. The thrice-daily administration acyclovir makes it challenging to deliver as outpatient We describe 2 cases with confirmed or presumed neonatal encephalitis treated administered a continuous-infusion at home and review the pharmacologic clinical evidence continuous infusions acyclovir.
Abstract Background Reducing antibiotic use in Australia, and the subsequent impact on antimicrobial resistance, requires multiple, sustained approaches with appropriate resources support. Additional strategies to reduce prescribing include effective vaccines, against pathogens such as Streptococcus pyogenes , most common bacterial cause of sore throat. As part efforts towards assessing benefits introducing new prescribing, we aimed determine burden for throat general practice. Methods...
We describe a 6-week-old male-term infant with pulmonary aspergilloma diagnosed following lobectomy for suspected pleuropulmonary blastoma, characteristic histopathologic findings and Aspergillus detected by polymerase chain reaction. Intensive testing did not reveal primary or secondary immunodeficiency. During 5 weeks treatment voriconazole including regular therapeutic drug monitoring dose adjustment, level in the target range was never achieved. When patient developed photosensitivity,...
Children with SARS-CoV-2 infection generally present milder symptoms or are asymptomatic in comparison adults, however severe disease occurs a subset of children. To date, the immune correlates COVID-19 young children have been poorly characterised.We report kinetics responses relation to clinical and virological features an infant acute using high-dimensional flow cytometry multiplex cytokine analysis.Systemic cellular profiling show initial increase neutrophils monocytes depletion lymphoid...
<h3>Background</h3> Multiple sclerosis (MS) is estimated to affect 2.8 million people worldwide, with increasing prevalence in all world regions (Walton <i>et al</i>). While there no cure for MS, medication and lifestyle modifications can slow disease progression enhance patients' quality of life. The biopsychosocial model health recognises important interactions among biological, psychological social factors illness, including those relating illness management, which contribute the...
Abstract Children have lower hospitalisation and mortality rates for coronavirus disease-2019 (COVID-19) than adults; however, younger children (<4 years of age) 1 may develop more severe disease older children. To date, the immune correlates COVID-19 in young been poorly characterized. We report kinetics responses relation to clinical virological features an infant with acute COVID-19. Systemic cellular cytokine profiling showed initial increase neutrophils monocytes depletion lymphoid...
There is no clear consensus about target oxygen saturations for children with bronchiolitis. Cunningham and colleagues1 completed a double-blind randomised trial evaluating the equivalence of 90% (intervention) versus 94% (standard) in The authors recruited 615 infants 6 weeks to 12 months age used primary outcome resolution cough as measure illness. It found between two groups, time 15 days (median difference 0 (confidence interval – 1 2). Equivalence was defined +/−2 days. We question use...
Case A 12-week-old man infant presented to the emergency department with a 4-day history of fever and diarrhea bright green stools, 24-hour nonbilious vomiting, lethargy irritability. He was born parents Vietnamese origin at 36-weeks gestation via normal vaginal delivery birth weight 1.8 kg. Serial antenatal ultrasounds for low fetal did not reveal any abnormalities. Postnatally, he admitted special care nursery 2 weeks monitor growth. Following discharge, exclusively breast-fed, tracking...