A5014459517- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- Respiratory viral infections research
- Long-Term Effects of COVID-19
- Global Maternal and Child Health
- Pediatric Urology and Nephrology Studies
- Urinary Tract Infections Management
- Child and Adolescent Health
- Urological Disorders and Treatments
- Emergency and Acute Care Studies
- Migration, Health and Trauma
- Respiratory Support and Mechanisms
- Kawasaki Disease and Coronary Complications
- Maternal and Neonatal Healthcare
- COVID-19 and Mental Health
- COVID-19 diagnosis using AI
- Neonatal Respiratory Health Research
- COVID-19 and healthcare impacts
- Tuberculosis Research and Epidemiology
- Urinary Bladder and Prostate Research
- Cardiac Arrest and Resuscitation
- Dermatological and COVID-19 studies
- Health and Conflict Studies
- Biosensors and Analytical Detection
Murdoch Children's Research Institute
2016-2025
Royal Children's Hospital
2016-2025
The University of Melbourne
2016-2025
Austin Health
2021
World Health Organization
2021
Parks Victoria
2021
Cornell University
2021
Weill Cornell Medicine
2021
NewYork–Presbyterian Brooklyn Methodist Hospital
2021
NYU Langone Health
2021
Post-acute COVID-19 outcomes in children with mild and asymptomatic diseaseData on the clinical of are scarce, particularly those disease. 1,2tudies involving adults suggest that long-term multisystem sequelae complications can occur, even COVID-19. 3We aimed to describe medium-term 3-6 months after diagnosis presenting a tertiary paediatric hospital.We followed (aged ≤18 years) at dedicated follow-up clinic Royal Children's Hospital (RCH) Melbourne, Australia, between March 21, 2020 17,...
Abstract The hallmarks of COVID-19 are higher pathogenicity and mortality in the elderly compared to children. Examining baseline SARS-CoV-2 cross-reactive immunological responses, induced by circulating human coronaviruses (hCoVs), is needed understand such divergent clinical outcomes. Here we show analysis coronavirus antibody responses pre-pandemic healthy children ( n = 89), adults 98), 57), patients 50) systems serology. Moderate levels cross-reactive, but non-neutralizing, antibodies...
<h3>Importance</h3> The immune response in children with SARS-CoV-2 infection is not well understood. <h3>Objective</h3> To compare seroconversion nonhospitalized and adults mild identify factors that are associated seroconversion. <h3>Design, Setting, Participants</h3> This household cohort study of collected weekly nasopharyngeal throat swabs blood samples during the acute (median, 7 days for 12 [IQR, 4-13] days) convalescent 41 31-49] periods after polymerase chain reaction (PCR)...
Aims: The optimal method for diagnostic collection of urine in children is unclear. National Institute Health and Clinical Excellence recommend specimens taken by clean catch (CCU) identification urinary tract infection (UTI). We investigated contamination rates CCU, suprapubic aspiration (SPA), catheter specimen (CSU) bag (BSU) collections. Method: Retrospective observational cohort study with review microbiology data medical records at a large tertiary children's hospital. reviewed culture...
Compared to adults, children with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have predominantly mild or asymptomatic infections, but the underlying immunological differences remain unclear. Here, we describe clinical features, virology, longitudinal cellular, and cytokine immune profile, SARS-CoV-2-specific serology salivary antibody responses in a family of two parents PCR-confirmed symptomatic SARS-CoV-2 infection their three children, who tested repeatedly PCR negative....
Abstract Children have mild severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) confirmed disease (COVID-19) compared to adults and the immunological mechanisms underlying this difference remain unclear. Here, we report convalescent innate immune responses in 48 children 70 infected with, or exposed to, SARS-CoV-2. We find clinically SARS-CoV-2 infection is characterised by reduced circulating subsets of monocytes (classical, intermediate, non-classical), dendritic cells natural...
As the establishment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific T cell memory in children remains largely unexplored, we recruited convalescent COVID-19 and adults to define their circulating SARS-CoV-2-specific CD4
<b>Objective</b> To determine if a simple stimulation method increases the rate of infant voiding for clean catch urine within five minutes. <b>Design</b> Randomised controlled trial. <b>Setting</b> Emergency department tertiary paediatric hospital, Australia. <b>Participants</b> 354 infants (aged 1-12 months) requiring sample collection as determined by treating clinician. 10 were subsequently excluded. <b>Interventions</b> Infants randomised to either gentle...
Objectives To examine the epidemiological and clinical characteristics of SARS-CoV-2-positive children in Australia during 2020. Design, setting Multicentre retrospective study 16 hospitals Paediatric Research Emergency Departments International Collaborative (PREDICT) network; eleven Victoria, five four other Australian states. Participants Children aged 0‒17 years who presented to hospital-based COVID-19 testing clinics, hospital wards, or emergency departments 1 February ‒ 30 September...
International studies describing COVID-19 in children have shown low proportions of paediatric cases and generally a mild clinical course. We aimed to present early data on tested for SARS-CoV-2 at large Australian tertiary children's hospital according the state health department guidelines, which varied over time.We conducted retrospective cohort study The Royal Children's Hospital, Melbourne, Australia. It included all patients (aged 0-18 years) who presented ED or Respiratory Infection...
Abstract Background To determine if dried blood spot specimens (DBS) can reliably detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies, we compared the SARS-CoV-2 IgG antibody response in paired serum and eluates from DBS specimens. Methods A total of 95 samples were collected 74 participants (aged 1–63 years) as part a household cohort study Melbourne, Australia. antibodies specific for receptor-binding domain (RBD) S1 proteins between using an FDA-approved ELISA...
Abstract There is limited understanding of antibody responses in children across different SARS-CoV-2 variants. As part an ongoing household cohort study, we assessed the response among unvaccinated infected with Wuhan, Delta, or Omicron variants, as well vaccinated breakthrough infection, using a S1-specific IgG assay and surrogate virus neutralization test (% inhibition). Most Delta (100%, 35/35) (81.3%, 13/16) variants seroconverted by one month following infection. In contrast, 37.5%...
Serological surveillance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies is important to monitor population COVID-19 immunity. Dried blood spots (DBS) are a valuable method for serosurveys, particularly in remote settings and children. We compared the measurement SARS-CoV-2 spike-specific IgG paired samples collected using standard venepuncture (serum) hemaPEN® microsampling DBS device from children adults. A total 83 participants (10 months 65 years age),...
The clinical course of Australian children admitted to hospital with COVID-19 infection is not well understood, particularly over the Omicron period.This study describes paediatric admissions a single tertiary institution through Delta and variant waves. All from 1 June 2021 30 September 2022 diagnosis were included for analysis.117 patients during wave compared 737 wave. median length stay was 3.3 days (IQR 1.7-6.75.1) Delta, 2.1 1.1-4.53.4) (p<0.01). 83 (9.7%) required intensive care unit...
Children have reduced severity of COVID-19 compared to adults and typically mild or asymptomatic disease. The immunological mechanisms underlying these age-related differences in clinical outcomes remain unexplained. Here, we quantify 23 immune cell populations 141 samples from children with their PCR-negative close household contacts at acute convalescent time points. displayed marked reductions myeloid cells during infection, most prominent under the age five. Recovery infection both was...
Abstract The duration of the humoral immune response in children infected with severe acute respiratory syndrome coronavirus 2 is unknown. We detected specific IgG 6 months after infection who were asymptomatic or had mild symptoms disease. These findings will inform vaccination strategies and other prevention measures.
Objective To present Australia-wide data on paediatric COVID-19 and multisystem inflammatory syndromes to inform health service provision vaccination prioritisation. Design Prospective, multicentre cohort study. Setting Eight tertiary hospitals across six Australian states territories in an established research surveillance network—Paediatric Active Enhanced Disease (PAEDS). Participants All children aged <19 years with SARS-CoV-2 infection including COVID-19, Paediatric Inflammatory...
Aim Clean catch urine ( CCU ) collection is commonly used in pre‐continent children. can be time‐consuming and specimens may contaminated. Our aim was to determine the time taken for attempts describe success of this method diagnosing or excluding urinary tract infection. Methods Prospective observational study children aged 2–48 months emergency department. Time until collection, ‘successful’ (voided caught), ‘missed’ not caught) procedure ‘stopped’, were recorded culture results analysed....
To examine refugee health assessments in Syrian and Iraqi children the context of changes to offshore immigration screening, updated Australian guidelines primary care model Victoria.This is a retrospective audit aged 0-17 years attending specialist immigrant service from January 2015 September 2017.We saw 128 (7 months-16 years, 64.8% male). Prior arrival, 58.9% had experienced trauma, 67.9% missed at least 1 year school. Almost all (93.3%) were linked with regular general practitioner...
Background Clean catch urine (CCU) collection in precontinent children is often time-consuming, with associated failure. We hypothesise that stimulating cutaneous reflexes hastens voiding for CCU. Methods 40 aged 1–24 months the ED. Standard CCU was augmented gentle suprapubic stimulation using saline-soaked gauze (Quick-Wee method). Results 12/40 (30%) voided within 5 min successful Parental and clinician satisfaction high. Conclusions Quick-Wee appears to be a simple method speed young children.