A5049164171- Respiratory viral infections research
- Influenza Virus Research Studies
- Pneumonia and Respiratory Infections
- Vaccine Coverage and Hesitancy
- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Bacterial Infections and Vaccines
- SARS-CoV-2 and COVID-19 Research
- Emergency and Acute Care Studies
- Viral gastroenteritis research and epidemiology
- Neonatal Respiratory Health Research
- Streptococcal Infections and Treatments
- Antimicrobial Resistance in Staphylococcus
- Cystic Fibrosis Research Advances
- Antibiotic Use and Resistance
- Bacterial Identification and Susceptibility Testing
- Infectious Encephalopathies and Encephalitis
- Child and Adolescent Health
- Neonatal and Maternal Infections
- Congenital Diaphragmatic Hernia Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Infective Endocarditis Diagnosis and Management
- Herpesvirus Infections and Treatments
- Viral Infections and Vectors
- Neutropenia and Cancer Infections
Princess Margaret Hospital for Children
2016-2025
Perth Children's Hospital
2018-2025
The Kids Research Institute Australia
2016-2025
The University of Western Australia
2016-2025
Pathwest Laboratory Medicine
2016-2025
Queen Elizabeth II Medical Centre
2016-2025
Breast Cancer Network Australia
2024
Australian Government
2019-2024
Government of Western Australia Department of Health
2014-2024
International Severe Acute Respiratory and Emerging Infection Consortium
2023
Abstract Public health measures targeting coronavirus disease 2019 have potential to impact transmission of other respiratory viruses. We found 98.0% and 99.4% reductions in syncytial virus influenza detections, respectively, Western Australian children through winter 2020 despite schools reopening. Border closures likely been important limiting external introductions.
Abstract Respiratory syncytial virus (RSV) is a leading cause of childhood morbidity, however there no systematic testing in children hospitalised with respiratory symptoms. Therefore, current RSV incidence likely underestimates the true burden. We used probabilistically linked perinatal, hospital, and laboratory records 321,825 born Western Australia (WA), 2000–2012. generated predictive model for positivity aged < 5 years. applied to all hospitalisations our population-based cohort...
Abstract Human respiratory syncytial virus (RSV) is an important cause of acute infection with the most severe disease in young and elderly. Non-pharmaceutical interventions travel restrictions for controlling COVID-19 have impacted circulation viruses including RSV globally, particularly Australia, where during 2020 normal winter epidemics were notably absent. However, late 2020, unprecedented widespread outbreaks occurred, beginning spring, extending into summer across two widely separated...
Following a relative absence in winter 2020, large resurgence of respiratory syncytial virus (RSV) detections occurred during the 2020/2021 summer Western Australia. This seasonal shift was linked to SARS-CoV-2 public health measures. We examine epidemiology and RSV testing respiratory-coded admissions, compare clinical phenotype RSV-positive admissions between 2019 2020.At single tertiary paediatric centre, International Classification Diseases, 10th edition Australian Modification-coded...
BackgroundIncreases in invasive group A streptococcal disease (iGAS) have recently been reported multiple countries the northern hemisphere, occurring during, and outside of, typical spring peaks. We report epidemiology of iGAS among children Australia from 1 July 2018 to 31 December 2022.MethodsThe Paediatric Active Enhanced Disease Surveillance (PAEDS) Network prospectively collected patient notifications for young people aged less than 18 years admitted five major Australian paediatric...
Influenza vaccine effectiveness and immunogenicity can be compromised with repeated vaccination. We assessed immunological markers in a cohort of healthcare workers (HCW) from six public hospitals around Australia during 2020-2021. Sera were collected pre-vaccination ~14 ~180 days post-vaccination haemagglutination inhibition assay against egg-grown equivalent cell-grown viruses. Responses to vaccination compared by the number prior vaccinations. Baseline sera available for 595 HCW 2020 1031...
The purpose of this work was to identify differences in incidence, risk factors, microbiology, treatment, and clinical outcome candidemia neonates, children, adults that might impact on management.Cases Australia were identified prospectively by blood culture surveillance over 3 years. Episodes neonatal, pediatric, adult age groups analyzed compared.Of 1005 incident cases, 33 occurred 110 862 adults. respective annual age-specific incidences 4.4, 0.9, 1.8 per 100,000 population. Prematurity...
Knowledge of contemporary epidemiology candidaemia is essential. We aimed to identify changes since 2004 in incidence, species and antifungal susceptibilities Candida spp. causing Australia.These data were collected from nationwide active laboratory-based surveillance for over 1 year (within 2014-2015). Isolate identification was by MALDI-TOF MS supplemented DNA sequencing. Antifungal susceptibility testing performed using Sensititre YeastOne™.A total 527 episodes (yielding 548 isolates)...
Recurrent acute otitis media (rAOM, recurrent ear infection) is a common childhood disease caused by bacteria termed otopathogens, for which current treatments have limited effectiveness. Generic probiotic therapies shown promise, but seem to lack specificity. We hypothesised that healthy children with no history of AOM carry protective commensal could be translated into specific therapy break the cycle re-infection. characterised nasopharyngeal microbiome these (controls) in comparison rAOM...
Background The 2010 influenza vaccination program for children aged 6 months to 4 years in Western Australia (WA) was suspended following reports of severe febrile reactions, including convulsions, with trivalent inactivated vaccine (TIV). Methods To investigate the association between reactions and TIV, three studies were conducted: (i) rates convulsions within 72 h receiving TIV estimated by formulation batch; (ii) numbers presenting hospital emergency departments from 2008 compared; (iii)...
Staphylococcus aureus bacteremia (SAB) in children causes significant morbidity and mortality, but the epidemiology is not well characterized.To describe of SAB adolescents younger than 18 years from Australia New Zealand.A prospective cohort study, using data Australian Zealand Cooperative on Outcomes Staphylococcal Sepsis for 1153 with birth to less pediatric general hospitals across Zealand, collected between January 1, 2007, December 31, 2012. Multivariate analysis was performed identify...
Rationale: Respiratory syncytial virus (RSV) bronchiolitis causes significant infant mortality. Bronchiolitis is characterized by airway epithelial cell (AEC) death; however, the mode of death remains unknown.Objectives: To determine whether necroptosis contributes to RSV pathogenesis via HMGB1 (high mobility group box 1) release.Methods: Nasopharyngeal samples were collected from children presenting hospital with acute respiratory infection. Primary human AECs and neonatal mice inoculated...
The incidence of Clostridium difficile infection (CDI) continues to rise, whilst treatment remains problematic due recurrent, refractory and potentially severe nature disease. C. is a challenge for community hospital-based clinicians. With the advent an expanding therapeutic arsenal against since last published Australasian guidelines, update on CDI recommendations clinicians was required. On behalf Society Infectious Diseases, we present updated guidelines management in adults children.
There are few longitudinal studies of seasonal influenza-associated neurological disease (IAND) and none from the Southern Hemisphere.We extracted prospectively acquired Australian surveillance data 2 nested within Paediatric Active Enhanced Disease Surveillance (PAEDS) network: Influenza Complications Alert Network (FluCAN) study Childhood Encephalitis (ACE) between 2013 2015. We described clinical features severity IAND in children, including encephalitis/encephalopathy (IAE). calculated...
Background Broad community acceptance of a COVID-19 vaccination will be critical for effectively halting the spread virus. In this study, we focus on factors that differentiate those who are undecided from either willing or unwilling to accept prospective vaccine. Methods An online survey in May 2020 assessed Australian adults’ willingness receive vaccine (yes, maybe, no). A multinomial logistical regression responses (N = 1,313) was used identify correlates between three groups. Results 65%...
Differentiating bacterial from viral pneumonia is important for guiding targeted management and judicious use of antibiotics. We assessed if clinical characteristics blood inflammatory biomarkers could be used to distinguish pneumonia.Western Australian children (≤17 years) hospitalized with radiologically-confirmed community-acquired were recruited symptoms data collected. C-reactive protein (CRP), white cell counts (WCC) absolute neutrophil (ANC) measured as part routine care. Clinical...