Anita Campbell
A5049468180- Antimicrobial Resistance in Staphylococcus
- Streptococcal Infections and Treatments
- Bacterial Identification and Susceptibility Testing
- Clostridium difficile and Clostridium perfringens research
- Antifungal resistance and susceptibility
- Antibiotic Use and Resistance
- Infective Endocarditis Diagnosis and Management
- Bacterial Infections and Vaccines
- Fungal Infections and Studies
- Sepsis Diagnosis and Treatment
- Microscopic Colitis
- Hearing Loss and Rehabilitation
- Epilepsy research and treatment
- Bacterial biofilms and quorum sensing
- Infectious Encephalopathies and Encephalitis
- Pneumonia and Respiratory Infections
- Antibiotic Resistance in Bacteria
- Eosinophilic Disorders and Syndromes
- Immunodeficiency and Autoimmune Disorders
- Linguistics and language evolution
- Ear Surgery and Otitis Media
- Animal Vocal Communication and Behavior
- Immune responses and vaccinations
- Avian ecology and behavior
- Dermatology and Skin Diseases
The University of Western Australia
2017-2025
Perth Children's Hospital
2018-2025
Princess Margaret Hospital for Children
2016-2025
The Kids Research Institute Australia
2017-2025
GTx (United States)
2024
Charles Darwin University
2021
Menzies School of Health Research
2021
Peter MacCallum Cancer Centre
2021
The University of Melbourne
2021
Office of Infectious Diseases
2021
The incidence of Clostridium difficile infection (CDI) continues to rise, whilst treatment remains problematic due recurrent, refractory and potentially severe nature disease. C. is a challenge for community hospital-based clinicians. With the advent an expanding therapeutic arsenal against since last published Australasian guidelines, update on CDI recommendations clinicians was required. On behalf Society Infectious Diseases, we present updated guidelines management in adults children.
Staphylococcus aureus bloodstream (SAB) infection is a common and severe infectious disease, with 90-day mortality of 15%-30%. Despite this, <3000 people have been randomized into clinical trials treatments for SAB infection. The limited evidence base partly results from infections being difficult to complete at scale using traditional trial methods. Here we provide the rationale framework an adaptive platform applied infections. We detail design features Network Adaptive Platform (SNAP)...
There is a recognized unmet need for clinical trials to provide evidence-informed care infants, children and adolescents. This Special Communication outlines the capacity of 3 distinct trial design strategies, sequential, parallel, unified adult-pediatric bayesian adaptive design, incorporate into transform this current state evidence inequity. A whole-of-life demonstrated through Staphylococcus aureus Network Adaptive Platform (SNAP) trial.
Abstract Background Appendicectomy for acute appendicitis in children may be performed specialist centres by paediatric surgeons or general surgery units. Service provision and outcome of appendicectomy differ between such Methods This multicentre observational study included all (aged less than 16 years) who had an at either a unit unit. The primary was normal rate (NAR). Secondary outcomes 30-day adverse events, use ultrasound imaging laparoscopy, consultant involvement procedures. Results...
Abstract Background The incidence, risks and organisms causing bloodstream infections (BSI) differ between children adults due to distinct comorbidities, procedures antibiotic exposures. Age-specific data are required inform targeted interventions, empiric treatment guideline development. We aimed compare the risk factors resistance patterns of bacteria BSI in (2020-21). Methods Australian Group on Antimicrobial Resistance (AGAR) is a national hospital-based surveillance program reporting...
Tuberculosis (TB) is caused by Mycobacterium tuberculosis (Mtb) and the leading cause of death. Bacillus Calmette-Guérin (BCG) only licensed TB vaccine. Preclinical studies have shown that in adults intravenous administration BCG improves protection against TB. We hypothesize intradermal to human newborn leads low grade bacteraemia this systemic dissemination Mtb infection. This hypothesis based on supporting observations including animal studies. It a testable offers deliver immediately...
Abstract Clostridioides difficile infection (CDI) is associated with significant morbidity and mortality within the Australian population. Treatment recommendations for CDI pose challenges at both community hospital‐based levels due to recurrent, refractory potentially severe nature of disease. Since last published Australasian guidelines in 2016, new therapeutic options are available, prompting a necessary update management recommendations. On behalf Society Infectious Diseases, we present...
Abstract Background Staphylococcus aureus is a common cause of bacteremia, yet the epidemiology and predictors poor outcome remain inadequately defined in childhood. Methods ISAIAH (Invasive Infections Hospitalizations children) prospective, cross-sectional study S. bacteremia (SAB) children hospitalized Australia New Zealand over 24 months (2017–2018). Results Overall, 552 SABs were identified (incidence 4.4/100 000/year). Indigenous children, those from lower socioeconomic areas neonates...
Staphylococcus aureus bloodstream infection (bacteremia) is traditionally treated with at least 2 weeks of intravenous (IV) antibiotics in adults, 3-7 days children, and often longer for those complicated disease. The current practice treating S. bacteremia (SAB) prolonged IV (rather than oral antibiotics) based on historical observational research expert opinion. Prolonged antibiotic therapy has significant disadvantages patients healthcare systems, there growing interest whether a switch...
Combination antibiotic therapy with an antitoxin agent, such as clindamycin, is included in some guidelines for severe, toxin-mediated Staphylococcus aureus infections. The evidence to support this practice currently limited vitro, animal and observational human case-series data, no previous randomized controlled trials (RCTs).This pilot RCT aimed determine the feasibility of conducting a clinical trial examine if adjunctive clindamycin standard has greater efficacy than alone S....
New and emerging risks for invasive aspergillosis (IA) bring the need contemporary analyses of epidemiology outcomes IA, in order to improve clinical practice.The study was a retrospective, multicenter, cohort design proven probable IA adults from 10 Australasian tertiary centres (January 2017-December 2020). Descriptive were used report patients' demographics, predisposing factors, mycological characteristics, diagnosis management. Accelerated failure-time model employed determine factor(s)...
From 1 January 2020 to 31 December 2021, thirty-eight institutions across Australia submitted data the Australian Group on Antimicrobial Resistance (AGAR) from patients aged < 18 years (AGAR-Kids). Over two years, 1,679 isolates were reported 1,611 patients. This AGAR-Kids report aims describe population of children and adolescents with bacteraemia AGAR proportion resistant isolates. Overall, there 902 gram-negative reported: 800 Enterobacterales, 61 Pseudomonas aeruginosa 41...
Abstract Background Rising proportions of antimicrobial resistance (AMR) have been observed in both Staphylococcus aureus and Enterococcus spp. isolates. Methods The Australian Group on Antimicrobial Resistance (AGAR) surveillance program captures clinical microbiological data isolates detected blood cultures across Australia. EUCAST 2022 was used for MIC interpretation the AMR package R analysis. Results There were 2,091 BSIs with S. 534 enterococcal BSI episodes over nine years....
Introduction Recent interest in the diverse ecosystem of bacteria, fungi and viruses that make up skin microbiome has led to numerous studies investigating healthy dermatological conditions. However, analysis is challenging due relatively low numbers microorganisms compared mucosal sites, such as respiratory or gastrointestinal tracts. Microbiome results are heavily influenced by sampling methods. Previous methods include cotton swabs, tape stripping, patch punch biopsies. It essential have...
There is increasing knowledge of antimicrobial usage in children yet limited availability nationally representative paediatric-specific data on resistance.Paediatric from this national surveillance programme are presented to explore differences between childhood and adult bloodstream infections resistance surveillance.Using information collected a prospective coordinated programme, ≤18 years adults >18 with positive blood culture for Staphylococcus aureus, Enterococcus spp. or Gram-negative...
Abstract Background For decades, the research community has called for participant information sheets/consent forms (PICFs) to be improved. Recommendations include simplifying content, reducing length, presenting in layers and using multimedia. However, there are relatively few studies that have evaluated health consumers’ (patients/carers) perspectives on type organisation of information, level detail included a PICF optimise an informed decision enter trial. We aimed elicit views layered...