A5043112440- Antifungal resistance and susceptibility
- Cytomegalovirus and herpesvirus research
- Mycobacterium research and diagnosis
- Fungal Infections and Studies
- Parvovirus B19 Infection Studies
- Infectious Diseases and Mycology
- Neutropenia and Cancer Infections
- Hematological disorders and diagnostics
- Antibiotic Use and Resistance
- Pneumocystis jirovecii pneumonia detection and treatment
- Infectious Diseases and Tuberculosis
- Herpesvirus Infections and Treatments
- Viral-associated cancers and disorders
- Bartonella species infections research
- Parasite Biology and Host Interactions
- Streptococcal Infections and Treatments
- Economic and Financial Impacts of Cancer
- Fungal Biology and Applications
- Viral Infections and Vectors
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Infective Endocarditis Diagnosis and Management
- Lymphoma Diagnosis and Treatment
- Tuberculosis Research and Epidemiology
- Toxoplasma gondii Research Studies
- Parasitic Diseases Research and Treatment
Northern Health
2025
The Royal Melbourne Hospital
2017-2024
Peter MacCallum Cancer Centre
2020-2024
The University of Melbourne
2017-2024
Victorian Comprehensive Cancer Centre
2019-2024
Peter Doherty Institute
2017
Abstract Invasive fungal diseases (IFD) are serious infections associated with high mortality, particularly in immunocompromised patients. The prescribing of antifungal agents to prevent and treat IFD is substantial economic burden on the health system, rates adverse drug reactions, significant drug–drug interactions emergence resistance. As population at risk continues grow due increased cancer related factors, need for hospitals employ stewardship (AFS) programmes measures monitor...
A 71-year-old Australian-born man with previous extended travel to the Philippines presented bilateral lymphoedema, fevers and rigors. Examination of a nocturnal blood film revealed microfilariae Wuchereria bancrofti, confirming diagnosis Bancroftian filariasis. This case highlights challenges diagnosing managing lymphatic filariasis in non-endemic regions.
Guidance on assessment of the quantity and appropriateness antifungal prescribing is required to assist hospitals interpret data effectively structure quality improvement programmes.To achieve expert consensus a core set stewardship (AFS) metrics determine their feasibility for implementation.A literature review was undertaken develop list candidate metrics. International experts were invited participate in sequential web-based surveys evaluate importance area AFS using Delphi methodology....
We describe a fatal case of Japanese encephalitis virus infection following short-term travel to Thailand. Viral RNA was detected in urine and whole blood out 26 28 days, respectively, after the onset symptoms. Live isolated from specimen day 14.
New and emerging risks for invasive aspergillosis (IA) bring the need contemporary analyses of epidemiology outcomes IA, in order to improve clinical practice.The study was a retrospective, multicenter, cohort design proven probable IA adults from 10 Australasian tertiary centres (January 2017-December 2020). Descriptive were used report patients' demographics, predisposing factors, mycological characteristics, diagnosis management. Accelerated failure-time model employed determine factor(s)...
Abstract We report four cases of invasive pulmonary aspergillus co‐infection in patients with coronavirus disease 2019 (COVID‐19) infection and acute respiratory distress syndrome requiring intensive care unit (ICU) admission. Aspergillus fumigatus terreus were isolated, early onset following ICU Clinicians should be aware aspergillosis COVID‐19 infection, particularly those receiving dexamethasone. propose screening these high‐risk twice‐weekly fungal culture from tracheal aspirate and, if...
Cytomegalovirus (CMV) infection increases mortality and morbidity following allogeneic hematopoietic stem-cell transplantation (alloHSCT). Universal antiviral prophylaxis with letermovir is effective but unsubsidized in Australia. Valaciclovir demonstrates anti-CMV activity high doses, few current real-world studies explore its use as primary high-risk patients post-alloHSCT.We performed a retrospective analysis of alloHSCT recipients at risk clinically significant CMV (cs-CMVi), defined...
The use of antithymocyte globulin (ATG) in allogeneic hematopoietic cell transplant (HCT) is associated with an increased risk Epstein-Barr virus (EBV) reactivation and post-transplant lymphoproliferative disorders (PTLD). dynamics outcomes EBV-DNAemia are not well described this population.We retrospectively assessed the kinetics after ATG conditioning HCT recipients. Receiver operating characteristic (ROC) curves were used to assess predict EBV-PTLD group.A total 174/405 (43%) consecutive...
Abstract Background Many patients with hematological malignancy develop fever after chemotherapy/conditioning but before chemotherapy-induced neutropenia (preneutropenic [PNF]). The proportion of PNF an infectious etiology is not well established. Methods We conducted a single-center, prospective observational substudy (neutrophils >0.5 cells/μL, ≥38.0°C) in adults receiving acute myeloid leukemia (AML) chemotherapy, or allogeneic hematopoietic cell transplant (allo-HCT) conditioning...
Background: New and emerging risks for invasive aspergillosis (IA) bring the need contemporary analyses of epidemiology outcomes IA, in order to improve clinical practice. Methods: The study was a retrospective, multicenter, cohort design proven probable IA adults from 10 Australasian tertiary centres (January 2017-December 2020). Descriptive were used report patients’ demographics, predisposing factors, mycological characteristics, diagnosis management. Cox regression employed determine...
Abstract Background A recent randomised trial demonstrated [ 18 F]fluorodeoxyglucose positron-emission tomography in combination with low-dose CT (FDG-PET/CT), compared to standard of care computed (CT) imaging, positively impacted antimicrobial management and outcomes acute leukaemia haematopoietic stem cell transplant recipients persistent recurrent neutropenic fever. We conducted an economic evaluation from a healthcare perspective alongside the clinical trial. Methods Unit costs...
C3 glomerulonephritis (C3GN) is a rare form of characterized by dominant staining for complement within the glomerulus, with dense deposits on electron microscopy.1 C3GN associated acquired or genetic factors that lead to impaired regulation alternative pathway (AP). Differentiating from "postinfectious" (PIGN) can be challenging because overlap in pathogenesis and clinical histologic characteristics.2 Thus, C3-dominant glomerular 1 5 classic clinicopathologic features described PIGN,3...
Introduction Understanding the economic impact of managing allogeneic hematopoietic stem cell transplant (HCT) recipients with cytomegalovirus (CMV) is important for future planning within institutional programs. CMV remains most frequent viral infection following HCT but less known about on health resource utilization. Objectives We aimed to evaluate burden in a large centre operating under universal care system. Methods A retrospective single study at Royal Melbourne Hospital, Australia...
Introduction In Australia, 18F-fluorodeoxyglucose positron emission tomography with low-dose computed (FDG-PET/CT) is currently only funded for cancer staging-related indications. A recent multicenter randomized trial demonstrated that FDG-PET/CT, compared standard of care (CT) imaging, improved antimicrobial management and the outcomes patients persistent recurrent neutropenic fever. There potential value in expanding use FDG-PET/CT as a diagnostic tool this high-risk population. We...
C3 glomerulonephritis (C3GN) is a rare renal disorder caused by excessive complement activation via the alternative pathway. Typical histological features include membranoproliferative (MPGN), C3-dominant glomerular staining and moderately dense deposits on electron microscopy (EM). C3GN overlaps clinically, histologically pathogenetically with postinfectious (PIGN), in which apparently triggered infection.