A5020487920- Vasculitis and related conditions
- Bartonella species infections research
- Rheumatoid Arthritis Research and Therapies
- Atherosclerosis and Cardiovascular Diseases
- Inflammatory Myopathies and Dermatomyositis
- Infectious Disease Case Reports and Treatments
- Neuroscience and Music Perception
- Muscle Physiology and Disorders
- Myasthenia Gravis and Thymoma
- Autoimmune and Inflammatory Disorders Research
- Rabies epidemiology and control
- Streptococcal Infections and Treatments
- Biosimilars and Bioanalytical Methods
- Family and Patient Care in Intensive Care Units
- Musculoskeletal synovial abnormalities and treatments
- Music Therapy and Health
- Muscle and Compartmental Disorders
- Oral Health Pathology and Treatment
- Systemic Lupus Erythematosus Research
- Heparin-Induced Thrombocytopenia and Thrombosis
The Royal Melbourne Hospital
2019-2024
Melbourne Health
2020
Importance There is a need for observational studies to supplement evidence from clinical trials, and the target trial emulation (TTE) framework can help avoid biases that be introduced when treatments are compared crudely using data by applying design principles randomized trials. Adalimumab (ADA) tofacitinib (TOF) were shown equivalent in patients with rheumatoid arthritis (RA) trial, but our knowledge, these drugs have not been head-to-head routinely collected TTE framework. Objective To...
Abstract Introduction: Muscle biopsy plays an important role in the diagnostic evaluation of individuals with suspected idiopathic inflammatory myopathies (IIM). However, variability practices may result a heterogenous patient experience. The existing literature offers limited insights into experiences and perspectives patients undergoing muscle biopsy. Methods: This study employed 27-item online survey to comprehensively characterise experience among Australian patients, including their...
C3 glomerulonephritis (C3GN) is a rare form of characterized by dominant staining for complement within the glomerulus, with dense deposits on electron microscopy.1 C3GN associated acquired or genetic factors that lead to impaired regulation alternative pathway (AP). Differentiating from "postinfectious" (PIGN) can be challenging because overlap in pathogenesis and clinical histologic characteristics.2 Thus, C3-dominant glomerular 1 5 classic clinicopathologic features described PIGN,3...
C3 glomerulonephritis (C3GN) is a rare renal disorder caused by excessive complement activation via the alternative pathway. Typical histological features include membranoproliferative (MPGN), C3-dominant glomerular staining and moderately dense deposits on electron microscopy (EM). C3GN overlaps clinically, histologically pathogenetically with postinfectious (PIGN), in which apparently triggered infection.
Background: Temporal artery biopsy (TAB) is widely recognised as the diagnostic gold standard for GCA despite having a poor sensitivity due to presence of ‘skip’ lesions. There is, however, lack consensus guiding TAB practice, particularly in relation optimal length, need bilateral specimens, and number segments examined. Objectives: To investigate impact factors such total biopsied laterality, segment number, referral centre on histopathological outcomes an Australian setting. Methods:...
Background Clinical practice surrounding giant cell arteritis (GCA) diagnosis, including the use of temporal artery biopsy (TAB) where appropriate, needs to be consistently accurate minimise both GCA-related end-organ damage and unnecessary glucocorticosteroid toxicity in all patients. Despite this imperative, delivery such clinical care, which can measured by diagnostic investigation performance characteristics as TAB positivity rates, varies substantially between different hospitals it is...