A5031953412- Systemic Sclerosis and Related Diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pulmonary Hypertension Research and Treatments
- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Healthcare Policy and Management
- Eosinophilic Esophagitis
- Biosimilars and Bioanalytical Methods
- Primary Care and Health Outcomes
- Autoimmune and Inflammatory Disorders Research
- Dermatologic Treatments and Research
- Muscle metabolism and nutrition
- Healthcare cost, quality, practices
- Coffee research and impacts
- Eosinophilic Disorders and Syndromes
- Thyroid Cancer Diagnosis and Treatment
- Pharmaceutical studies and practices
- Salivary Gland Disorders and Functions
- Connective Tissue Growth Factor Research
- Mast cells and histamine
- Dysphagia Assessment and Management
- Vasculitis and related conditions
- Vascular Anomalies and Treatments
- Celiac Disease Research and Management
- Vaccine Coverage and Hesitancy
St Vincent's Hospital
2014-2024
The University of Melbourne
2015-2024
Queen Elizabeth Hospital
2020-2024
National Health and Medical Research Council
2022
Australian Government
2022
Center for Rheumatology
2021
Royal Adelaide Hospital
2020
Abstract Objectives To quantify the frequency and impact of malnutrition in systemic sclerosis (SSc), as diagnosed by Global Leadership Initiative on Malnutrition (GLIM) criteria, based weight loss, BMI muscle atrophy. Methods Australian Scleroderma Cohort Study participants meeting ACR/EULAR criteria for SSc with ≥1 concurrent height measurement were included. The chi-squared test, two-sample t-test or Wilcoxon’s rank-sum test was used between-group comparison appropriate. Multivariable...
This study investigated the ergogenic effects of a commercial energy drink (Red Bull) or an equivalent dose anhydrous caffeine in comparison with noncaffeinated control beverage on cycling performance. Eleven trained male cyclists (31.7 ± 5.9 y 82.3 6.1 kg, VO2max = 60.3 7.8 mL · kg-1 min-1) participated double-blind, placebo-controlled, crossover-design involving 3 experimental conditions. Participants were randomly administered Red Bull (9.4 mL/kg body mass [BM] containing mg/kg BM...
Importance There is a need for observational studies to supplement evidence from clinical trials, and the target trial emulation (TTE) framework can help avoid biases that be introduced when treatments are compared crudely using data by applying design principles randomized trials. Adalimumab (ADA) tofacitinib (TOF) were shown equivalent in patients with rheumatoid arthritis (RA) trial, but our knowledge, these drugs have not been head-to-head routinely collected TTE framework. Objective To...
Screening for pulmonary arterial hypertension (PAH) in systemic sclerosis (SSc) is now standard care this disease. The existing Australian Scleroderma Interest Group algorithm (ASIGSTANDARD ) based on transthoracic echocardiography (TTE) and function tests (PFT). Recently, ASIG has derived validated a new screening (ASIGPROPOSED that incorporates N-terminal pro-B-type natriuretic peptide level together with PFT order to decrease reliance TTE, which some limitations. Right heart...
Objectives The gastrointestinal tract (GIT) is the most commonly affected internal organ in systemic sclerosis (SSc). We sought to determine prevalence and impact of GIT symptoms on survival patient‐reported outcomes. Methods 907 consecutive patients from Australian Scleroderma Cohort Study (ASCS) who had prospectively completed University California Los Angeles Clinical Trials Consortium Gastrointestinal Tract 2.0 questionnaire (UCLA GIT) between 2015 2021 were included. association UCLA...
Immune checkpoint inhibitor therapy is frequently associated with immune-related adverse events, which occasionally manifest visual symptoms. Here, we describe a case of unilateral and sudden-onset painless vision loss in an 82-year-old man metastatic non-small cell lung cancer receiving immunotherapy the anti-programmed death-ligand 1 agent atezolizumab. Examination demonstrated right-sided relative afferent pupillary defect, diffusely swollen optic disc, delayed choroidal retinal arterial...
To determine vaccination rates, perceptions, and information sources in people with inflammatory arthritis.Participants enrolled the Australian Rheumatology Association Database were invited to participate an online questionnaire, conducted January 2020, prior COVID-19 pandemic. Included questions about history, modified World Health Organization Vaccination Hesitancy Scale, views of consulted, Beliefs About Medicines Questionnaire, education, Single-Item Literacy Screener.Response rate was...
Abstract Background To determine the relationship between gastroesophageal reflux disease (GORD) and its treatment interstitial lung in patients with systemic sclerosis (SSc). Methods SSc from Australian Scleroderma Cohort Study (ASCS) were included. GORD was defined as self-reported symptoms, therapy a proton pump inhibitor (PPI) or histamine 2 receptor antagonist (H2RA) and/or presence of oesophagitis diagnosed endoscopically. The impact on ILD features (including severity time to...
Patients with pulmonary arterial hypertension (PAH) may be stratified as low, intermediate, or high risk of 1-year mortality. In 2022, the European Society Cardiology (ESC) updated and simplified its stratification tool, based on three variables: World Health Organization functional class, serum N-terminal pro-brain type natriuretic peptide six-minute walk distance, applied at follow-up visits, intended to guide therapy over time.
To investigate the knowledge and beliefs of Australian patients with inflammatory arthritis regarding biologic/targeted synthetic DMARDs (b/tsDMARDs) biosimilars their sources information.Participants enrolled in Rheumatology Association Database (ARAD) RA, PsA axial SpA were sent an online survey. They asked about information for b/tsDMARDs how positive or negative this was. The Beliefs Medicine Questionnaire (BMQ) was used to measure scores ranging from 1 (strongly disagree) 5 agree)....
Abstract Background Biologic and targeted synthetic disease modifying agents (b/tsDMARDs) have broadened the treatment landscape for autoimmune diseases particularly in patients refractory to conventional DMARDs. More recently, introduction of biosimilars has reduced price bDMARDs, potentially improving accessibility. Though efficacy safety been described, patient attitudes b/tsDMARDs are not well-understood. We aim investigate patients’ beliefs about biologic biosimilar therapy, factors...
Abstract Pulmonary arterial hypertension is an important cause of death and disability in patients with systemic sclerosis (SSc). Yearly screening all SSc transthoracic echocardiography (TTE) recommended international guidelines currently utilised by the Australian Scleroderma Interest Group (ASIG STANDARD ). Owing to limitations TTE, ASIG developed a new algorithm PROPOSED ) utilising serum biomarker, NT‐proBNP, place which has been shown be equally accurate as current algorithm. The aim...
Objective To assess whether patient and physician global assessment of gastrointestinal tract (GIT) disease in systemic sclerosis (SSc) are associated with a meaningful change status. Methods One hundred forty-three participants from the Australian Scleroderma Cohort Study were recruited to this study. Using logistic regression analysis, we evaluated relationship between patient-reported physician-assessed GIT status symptoms, measures health-related quality life (36-item Short Form Health...
Background: Biologic and targeted synthetic disease modifying agents (b/tsDMARDs) have considerably broadened the treatment landscape for autoimmune diseases, providing effective alternatives to traditional immunosuppressants glucocorticoids.There are currently 15 b/tsDMARDs available under Pharmaceutical Benefits Scheme (PBS) of inflammatory arthritis (IA) five bowel (IBD).Some these (e.g., TNF inhibitors) indications both IA IBD while others specific a single indication such as...
The aim of this study was to determine the impact season, temperature and humidity on severity Raynaud phenomenon in systemic sclerosis.