A5063393123- Drug-Induced Adverse Reactions
- Antifungal resistance and susceptibility
- Neutropenia and Cancer Infections
- Bacterial Identification and Susceptibility Testing
- Fungal Infections and Studies
- Contact Dermatitis and Allergies
- Food Allergy and Anaphylaxis Research
- Hematological disorders and diagnostics
- Antibiotic Use and Resistance
- Pharmacovigilance and Adverse Drug Reactions
- Urticaria and Related Conditions
- Antimicrobial Resistance in Staphylococcus
- Pneumocystis jirovecii pneumonia detection and treatment
- Autoimmune Bullous Skin Diseases
- Infective Endocarditis Diagnosis and Management
- Herpesvirus Infections and Treatments
- SARS-CoV-2 and COVID-19 Research
- Immunodeficiency and Autoimmune Disorders
- Infectious Diseases and Tuberculosis
- Antibiotic Resistance in Bacteria
- Patient Satisfaction in Healthcare
- Infectious Diseases and Mycology
- Economic and Financial Impacts of Cancer
- Streptococcal Infections and Treatments
- Nail Diseases and Treatments
Peter MacCallum Cancer Centre
2016-2025
Austin Health
2021-2025
The University of Melbourne
2009-2025
U-M Rogel Cancer Center
2025
Austin Hospital
2025
GTx (United States)
2022
Museum of Heilongjiang Province
2021
The Royal Melbourne Hospital
2016-2020
Victorian Comprehensive Cancer Centre
2020
Epworth Hospital
2018
Penicillin allergy is a significant public health issue for patients, antimicrobial stewardship programs, and services. Validated clinical decision rules are urgently needed to identify low-risk penicillin allergies that potentially do not require skin testing by specialist.To develop validate rule enables point-of-care risk assessment of patient-reported allergies.In this diagnostic study, multicenter prospective antibiotic allergy-tested cohort 622 patients from 2 tertiary care sites in...
Abstract Invasive aspergillosis (IA) in haematology/oncology patients presents as primary infection or breakthrough infection, which can become refractory to antifungal treatment and has a high associated mortality. Other emerging patient risk groups include the intensive care setting with severe respiratory viral infections, including COVID‐19. These guidelines present key diagnostic recommendations light of advances knowledge since previous 2014. Culture histological‐based methods remain...
Importance Fewer than 5% of patients labeled with a penicillin allergy are truly allergic. The standard care to remove the label in adults is specialized testing involving prick and intradermal skin followed by an oral challenge penicillin. Skin resource intensive, limits practice specialist-trained physicians, restricts global population who could undergo delabeling. Objective To determine whether direct noninferior low-risk allergy. Design, Setting, Participants This parallel, 2-arm,...
Penicillin allergies are associated with inferior patient and antimicrobial stewardship outcomes. We implemented a whole-of-hospital program to assess the efficacy of inpatient delabeling for low-risk penicillin in hospitalized inpatients.Patients ≥ 18 years age allergy were offered single-dose oral challenge or direct label removal based on history (direct delabeling). The primary endpoint was proportion patients delabeled. Key secondary endpoints antibiotic utilization pre- (index...
Abstract Antibiotic allergies are reported by up to 1 in 4 cancer patients, almost 50% of which considered low risk and precede the diagnosis. We demonstrate successful safe implementation a pilot oral penicillin challenge program for patients with low-risk allergies, increasing use narrow-spectrum beta-lactams post-testing.
Abstract Background Invasive Aspergillus spp. infections (IAI) confer high morbidity and mortality in immunocompromised patients. Diagnosis often requires invasive risky sampling. 18F-fluorodeoxyglucose positron emission tomography with computed (FDG-PET/CT) is useful diagnosis but non-specific. Siderophores are pathogen-specific iron chelators which a promising radiolabelling target for IAI diagnosis. fumigatus secretes 2 siderophores, fusarinine C triacetylfusarinine (TAFC), upregulated...
Purpose of review To the benefits, risks and specific considerations surrounding antibacterial prophylaxis (ABP) in adults with neutropenia, focusing primarily on high-risk patients hematologic malignancies (HM) and/or hematopoietic cell transplantation (HCT). Recent findings There has been an overall reduction benefit fluoroquinolone (FQP) observed recent studies, a lack mortality less efficacy reducing Gram-negative bloodstream infections (BSI) rates, which may be explained by increasing...
Abstract Background Vancomycin-resistant enterococcus (VRE) is an important cause of infection in immunocompromised populations. Few studies have described the characteristics vanB VRE infection. We sought to describe epidemiology, treatment and outcomes bloodstream infections (BSI) a predominant setting malignant hematology oncology patients. Methods A retrospective review was performed at two large Australian centres spanning 6-year period (2008–2014). Evaluable were intensive care...
Guidance on assessment of the quantity and appropriateness antifungal prescribing is required to assist hospitals interpret data effectively structure quality improvement programmes.To achieve expert consensus a core set stewardship (AFS) metrics determine their feasibility for implementation.A literature review was undertaken develop list candidate metrics. International experts were invited participate in sequential web-based surveys evaluate importance area AFS using Delphi methodology....
Abstract Inpatient direct oral challenge programs are increasingly deployed as part of antimicrobial stewardship initiatives to reduce the burden and impacts penicillin allergy labels on antibiotic prescribing. Using data from a prospective, multicenter cohort inpatient program, we identify key targets for delabeling aid health service implementation.
Abstract Background Neutropenic fever (NF) is a common complication in patients receiving chemotherapy. Judicious antimicrobial use paramount to minimize morbidity and mortality avoid antimicrobial-related harms. Objectives To an Australian national dataset of prescriptions for the treatment NF describe use, prescription guideline compliance appropriateness; compare these findings across different healthcare settings patient demographics. We also aimed identify trends practice changes over...