Matthew Scarborough
A5063473429- Orthopedic Infections and Treatments
- Antimicrobial Resistance in Staphylococcus
- Bacterial Infections and Vaccines
- Infective Endocarditis Diagnosis and Management
- Infectious Diseases and Tuberculosis
- Orthopaedic implants and arthroplasty
- Pneumonia and Respiratory Infections
- Surgical site infection prevention
- Total Knee Arthroplasty Outcomes
- Bacterial Identification and Susceptibility Testing
- Antifungal resistance and susceptibility
- Pneumocystis jirovecii pneumonia detection and treatment
- Bone fractures and treatments
- Respiratory viral infections research
- Clostridium difficile and Clostridium perfringens research
- Intramuscular injections and effects
- Hematological disorders and diagnostics
- Health Systems, Economic Evaluations, Quality of Life
- Antibiotic Use and Resistance
- Thermal Regulation in Medicine
- Osteomyelitis and Bone Disorders Research
- Climate Change and Health Impacts
- Bacterial biofilms and quorum sensing
- Fungal Infections and Studies
- Child and Adolescent Health
McGill University
2025
Oxford University Hospitals NHS Trust
2014-2024
University of Oxford
2015-2024
Nuffield Orthopaedic Centre
2015-2024
McGill University Health Centre
2022
John Radcliffe Hospital
2008-2021
Merck & Co., Inc., Rahway, NJ, USA (United States)
2020
Clinical Orthopaedics and Related Research
2020
University Medical Center Groningen
2020
Angelini Pharma (Italy)
2020
The management of complex orthopedic infections usually includes a prolonged course intravenous antibiotic agents. We investigated whether oral therapy is noninferior to for this indication.
Chronic osteomyelitis may recur if dead space management, after excision of infected bone, is inadequate. This study describes the results a strategy for management deep bone infection and evaluates new antibiotic-loaded biocomposite in eradication from defects.We report prospective 100 patients with chronic osteomyelitis, 105 bones. Osteomyelitis followed injury or surgery 81 patients. Nine had concomitant septic arthritis. 80 comorbidities (Cierny-Mader (C-M) Class B hosts). Ten nonunions....
In sub-Saharan Africa, bacterial meningitis is common and associated with a high mortality. Adjuvant therapy corticosteroids reduces mortality among adults in the developed world, but it has not been adequately tested developing countries or context of advanced human immunodeficiency virus (HIV) infection.
BackgroundStaphylococcus aureus bacteraemia is a common cause of severe community-acquired and hospital-acquired infection worldwide. We tested the hypothesis that adjunctive rifampicin would reduce bacteriologically confirmed treatment failure or disease recurrence, death, by enhancing early S killing, sterilising infected foci blood faster, reducing risks dissemination metastatic infection.MethodsIn this multicentre, randomised, double-blind, placebo-controlled trial, adults (≥18 years)...
Streptococci are not an infrequent cause of periprosthetic joint infection (PJI). Management by debridement, antibiotics, and implant retention (DAIR) is thought to produce a good prognosis, but little known about the real likelihood success. A retrospective, observational, multicenter, international study was performed during 2003–2012. Eligible patients had streptococcal PJI that managed with DAIR. The primary endpoint failure, defined as death related infection, relapse/persistence or...
Current guidelines recommend collection of multiple tissue samples for diagnosis prosthetic joint infections (PJI). Sonication explanted devices has been proposed as a potentially simpler alternative; however, reported microbiological yield varies. We evaluated sonication PJI and other orthopedic device-related (DRI) at the Oxford Bone Infection Unit between October 2012 August 2016. compared performance paired cultures against "gold standard" published clinical composite definitions...
Aims Excision of chronic osteomyelitic bone creates a dead space which must be managed to avoid early recurrence infection. Systemic antibiotics cannot penetrate this in high concentrations, so local treatment has become an attractive adjunct surgery. The aim study was present the mid- long-term results with gentamicin bioabsorbable ceramic carrier. Methods A prospective series 100 patients Cierny-Mader Types III and IV ostemyelitis, affecting 105 bones, were treated single-stage procedure...
<h3>SETTING</h3> Inpatient medical wards, Department of Medicine, University Teaching Hospital, Lusaka, Zambia. <h3>OBJECTIVE</h3> To define the natural history, clinical presentation, and management outcome microbiologically confirmed cryptococcal meningitis in adult AIDS patients treated under local conditions where antifungal antiretroviral therapies are not routinely available. <h3>DESIGN</h3> A descriptive, longitudinal, observational study. <h3>METHODS</h3> All admitted to wards Zambia...
Fosfomycin is increasingly called upon for the treatment of multi drug-resistant (MDR) organisms causing urinary tract infection (UTI). We reviewed oral fosfomycin use UTI in a large UK hospital. The primary goal was to audit our clinical practice against current national guidelines. Secondary aims were identify factors associated with failure, and investigate potential using patients co-morbidities.We retrospectively studied 75 adult who received 151 episodes from March 2013 June 2015....
Background Management of bone and joint infection commonly includes 4–6 weeks intravenous (IV) antibiotics, but there is little evidence to suggest that oral (PO) therapy results in worse outcomes. Objective To determine whether or not PO antibiotics are non-inferior IV treating infection. Design Parallel-group, randomised (1 : 1), open-label, non-inferiority trial. The margin was 7.5%. Setting Twenty-six NHS hospitals. Participants Adults with a clinical diagnosis bone, orthopaedic...
There is a recognized unmet need for clinical trials to provide evidence-informed care infants, children and adolescents. This Special Communication outlines the capacity of 3 distinct trial design strategies, sequential, parallel, unified adult-pediatric bayesian adaptive design, incorporate into transform this current state evidence inequity. A whole-of-life demonstrated through Staphylococcus aureus Network Adaptive Platform (SNAP) trial.
ObjectivesInfective endocarditis (IE) is a severe complication in Staphylococcus aureus bacteraemia (SAB) and recent guidelines from the BSAC recommend all patients undergo echocardiography. We assessed use of echocardiography at major tertiary referral centre sought to identify those most likely have positive findings.
Mortality from bacterial meningitis in African adults is significantly higher than those better resourced settings and adjunctive therapeutic interventions such as dexamethasone glycerol have been shown to be ineffective. We conducted a study analysing data clinical trials of Blantyre, Malawi investigate the parameters associated with this high mortality. Methods searched for all undertaken Blantyre investigating 1990 current time combined included trial datasets into one database. used...
Bone and joint infection in adults arises most commonly as a complication of replacement surgery, fracture fixation diabetic foot infection. The associated morbidity can be devastating to patients costs the National Health Service an estimated £20,000 £40,000 per patient. Current standard care UK centres includes prolonged course (4-6 weeks) intravenous antibiotics supported, if available, by outpatient parenteral antibiotic therapy service. Intravenous carries with it substantial risks...
Orthopaedic infections, such as osteomyelitis, diabetic foot infection and prosthetic joint infection, are most commonly treated by a combination of surgical debridement prolonged course systemic antibiotics, usually for at least 4-6 weeks. Use local implanted directly into the site time surgery, may improve antibiotic delivery allow us to shorten duration therapy, thereby limiting frequency side effects, cost selection pressure antimicrobial resistance.SOLARIO is multicentre open-label...
Abstract Background Surgical débridement, antibiotics and implant retention (DAIR) is currently recommended by international guidelines for both early acute (postsurgical) late (hematogenous) periprosthetic joint infections (PJIs). However, due to a different pathogenesis of infection, treatment strategy may be needed. Questions/purposes (1) Compared with PJIs, are PJIs associated higher risk DAIR failure? (2) When stratified microorganism, the failure in PJI Staphylocococcus aureus...
Abstract Background The use of adjunctive antibiotics directed against exotoxin production in Staphylococcus aureus bacteremia (SAB) is widespread, and it recommended many guidelines, but this based on limited evidence. Existing guidelines are the theoretical premise toxin suppression, as strains S. produce toxins such leukocidins (eg, Panton-Valentine leukocidin, toxic shock syndrome 1, exfoliative toxins, various enterotoxins). Many clinicians therefore believe that limiting release by...