A5107303831- Orthopedic Infections and Treatments
- Antimicrobial Resistance in Staphylococcus
- Infectious Diseases and Tuberculosis
- Infective Endocarditis Diagnosis and Management
- Streptococcal Infections and Treatments
- Pharmaceutical Practices and Patient Outcomes
- Bacterial Identification and Susceptibility Testing
- Antibiotics Pharmacokinetics and Efficacy
- Bacterial Infections and Vaccines
- Otolaryngology and Infectious Diseases
- Pharmacovigilance and Adverse Drug Reactions
- Healthcare Systems and Practices
- Antibiotic Resistance in Bacteria
- Health, Medicine and Society
- Infectious Encephalopathies and Encephalitis
- Mycobacterium research and diagnosis
- Sepsis Diagnosis and Treatment
- Antibiotic Use and Resistance
- Herpesvirus Infections and Treatments
- Emergency and Acute Care Studies
- Pharmaceutical studies and practices
- Osteomyelitis and Bone Disorders Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Tuberculosis Research and Epidemiology
- Pneumonia and Respiratory Infections
Inserm
2018-2024
Centre d'Investigation Clinique de Nantes
2013-2024
Hôpital Bichat-Claude-Bernard
2020
Clinical Investigation Center Plurithematic Tours
2020
Assistance Publique – Hôpitaux de Paris
2020
Nantes Université
2002-2019
Centre Hospitalier Universitaire de Nantes
2004-2019
The Enteric Nervous System in Gut and Brain Disorders
2019
Centre Hospitalier Universitaire d'Angers
2018
Aidjan-Lagos Corridor Organization
2017
Streptococci are not an infrequent cause of periprosthetic joint infection (PJI). Management by debridement, antibiotics, and implant retention (DAIR) is thought to produce a good prognosis, but little known about the real likelihood success. A retrospective, observational, multicenter, international study was performed during 2003–2012. Eligible patients had streptococcal PJI that managed with DAIR. The primary endpoint failure, defined as death related infection, relapse/persistence or...
Little is known about the relation of adverse drug reactions (ADRs) to self-use medications.The aim this study was determine frequency and severity ADRs related self-medication (ADR-SM) among emergency department (ED) patients describe their main characteristics.A prospective, cross-sectional, observational conducted over a period 8 weeks (1 March 20 April 2010), in ED 11 French academic hospitals. Adult presenting during randomization periods were included, with exception cases self-drug...
Pneumocystis jirovecii pneumonia (PJP) remains a severe disease associated with high rates of invasive mechanical ventilation (MV) and mortality. The objectives this study were to assess early risk factors for PJP 90-day mortality, including the broncho-alveolar lavage fluid cytology profiles at diagnosis.We prospectively enrolled all patients meeting pre-defined diagnostic criteria admitted Nantes university hospital, France, from January 2012 2017. Diagnostic typical clinical features...
A retrospective study about Propionibacterium acnes infections after Cotrel-Dubousset (CD) instrumentation.To analyze the significance of P. acnes-positive deep samples CD.The diagnosis spinal to CD is difficult.Patients with revision surgery and at least 1 sample, between 2000 2006 were included. Group had group B 2 successive surgeries, samples. was divided into subgroups according peroperative macroscopic aspect, subgroup A1 septic tissues, A2 without tissues. The biologic characteristics...
Ludwig's angina has been known for two centuries as a rapidly and frequently fatal progressive gangrenous cellulitis or necrotizing fasciitis of the neck floor mouth. The management usually young patients affected requires trained team combining medical skills in surgery, antibiotic therapy, resuscitation. prognosis is directly related to early surgical debridement experience managing these patients. We present four cases severe cervical notably associated with concomitant self-medication...
The optimal treatment of streptococcal prosthetic joint infections (PJIs) is unclear.A cohort PJIs was reviewed retrospectively in seven reference centers for the management complex bone and infections, covering period January 1, 2010 to December 31, 2012.Seventy patients with monomicrobial were included: 47 had total hip arthroplasty 23 knee arthroplasty. median age 77 years (interquartile range (IQR) 69-83 years), Charlson comorbidity score 4 (IQR 3-6), 15.6% (n=11) diabetes. most commonly...
High dosages of ceftriaxone are used to treat central nervous system (CNS) infections. Dosage adaptation according the glomerular filtration rate is currently not recommended. Ceftriaxone pharmacokinetics (PK) was investigated by a population approach in patients enrolled French multicenter prospective cohort study who received high-dose for CNS infection as recommended guidelines (75 100 mg/kg body weight/day without an upper limit). Only those with suspected bacterial meningitis were...
Objectives The frequency and the severity of drug-related visits in emergency department (ED) make improvement adverse drug event (ADE) recognition a crucial issue. As part research project aiming to improve diagnosis management ADEs ED, authors conducted pilot study whose primary objective was assess ADE by physicians. Methods patients presenting ED were included at randomised time periods between 1 October 2007 31 March 2008 this prospective cross-sectional study. outcome that attributed...
Complement system is a part of innate immunity, its main function to protect human from bacterial infection. As genetic disorders, complement deficiencies are often diagnosed in pediatric population. However, can also be revealed adults but have been poorly investigated. Herein, we describe case series infections revealing deficiency study clinical spectrum and management deficiencies. A nationwide retrospective was conducted French university general hospitals departments internal medicine,...
The identification of Propionibacterium acnes in cultures bone and joint samples is always difficult to interpret because the ubiquity this microorganism. aim study was propose a diagnostic strategy distinguish infections from contaminations. This retrospective analysis all patient charts those patients with >or=1 deep culture-positive for P. acnes. Every criterion tested sensitivity, specificity, positive likelihood ratio, then probability combinations criteria calculated. Among 65...
Abstract In nonoperated prosthetic valve endocarditis (PVE), long-term outcome is largely unknown. We report the follow-up of 129 patients with PVE alive at discharge. At 1 year, mortality rate was 24%; relapses and reinfection were rare (5% each). Enterococcal associated a higher risk relapse.
Abstract Background In the management of infective endocarditis (IE), presence extracardiac complications has an influence on both diagnosis and treatment. Current guidelines suggest that systematic thoracoabdominal-pelvic computed tomography (TAP-CT) may be helpful. Our objective was to describe how TAP-CT affects IE. Methods this multicenter cohort study, between January 2013 July 2016 we included consecutive patients who had definite or possible IE according Duke modified criteria,...
New diagnostic tools have been developed to improve the diagnosis of infectious encephalitis. Using a prospective cohort encephalitis patients, our objective was identify possible clusters patients with similar patterns among unknown cause (EUC) and describe what extent patient's initial presentation may be predictive etiology, particularly herpes simplex virus (HSV) varicella-zoster (VZV).The National Cohort Infectious Encephalitis in France is an ongoing study implemented 2016. Patients...
Abstract Objectives To describe the outcome and risk factors for treatment failure of 76 Gram-negative bacilli (GNB) prosthetic joint infections (PJIs) managed with a curative intent according to standardized protocol derived from published guidelines. Methods We analysed data all cases GNB-PJI treated surgically over an 8 year period. Treatment was defined as persistence or recurrence PJI signs during follow-up, resulting in additional surgery and/or antibiotic administration death. Results...
Background Potassium disturbances are associated with adverse prognosis in patients chronic conditions. Its prognostic implications stable attending the emergency department (ED) is poorly described. Aims This study aimed to assess prevalence of dyskalemia, describe its predisposing factors and associations a population presenting ED without unstable medical illness. Methods Post-hoc analysis prospective, cross-sectional, multicenter 11 French academic hospitals over period 8 weeks. All...