Pierre Jaquet
A5036902332- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Infectious Encephalopathies and Encephalitis
- Herpesvirus Infections and Treatments
- Cardiac Arrest and Resuscitation
- Intensive Care Unit Cognitive Disorders
- Autoimmune Neurological Disorders and Treatments
- Mechanical Circulatory Support Devices
- Respiratory Support and Mechanisms
- COVID-19 and healthcare impacts
- Traumatic Brain Injury and Neurovascular Disturbances
- Antibiotics Pharmacokinetics and Efficacy
- Peripheral Neuropathies and Disorders
- Vagus Nerve Stimulation Research
- SARS-CoV-2 and COVID-19 Research
- Sepsis Diagnosis and Treatment
- Anesthesia and Sedative Agents
- Cytomegalovirus and herpesvirus research
- Adrenal Hormones and Disorders
- Mosquito-borne diseases and control
- Machine Learning in Healthcare
- Inflammatory Biomarkers in Disease Prognosis
- Mobile Agent-Based Network Management
- Facial Nerve Paralysis Treatment and Research
- Poxvirus research and outbreaks
Centre Hospitalier Saint-Denis
2023-2025
Hôpital Bichat-Claude-Bernard
2019-2024
Assistance Publique – Hôpitaux de Paris
2019-2024
Maison des Sciences de l’Homme de Dijon
2024
CIC Rennes
2024
Yves Rocher (France)
2024
Université Claude Bernard Lyon 1
2019-2023
Inserm
2023
Hôpital Pontchaillou
2023
Hôpital Jean-Verdier
2023
The benefit of high-dose dexamethasone and oxygenation strategies vs standard care for patients with severe acute hypoxemic respiratory failure (AHRF) caused by COVID-19 pneumonia is debated.To assess the compared dexamethasone, to high-flow nasal oxygen (HFNo2) or continuous positive airway pressure (CPAP) support (o2SC).This multicenter, placebo-controlled randomized clinical trial was conducted in 19 intensive units (ICUs) France from April 2020 January 2021. Eligible were consecutive...
Prone positioning may improve outcomes in patients with severe acute respiratory distress syndrome (ARDS), but it is unknown whether prone improves clinical among ARDS who are undergoing venovenous extracorporeal membrane oxygenation (VV-ECMO) compared supine positioning.
Abstract Background Data in the literature about HSV reactivation COVID-19 patients are scarce, and association between HSV-1 mortality remains to be determined. Our objectives were evaluate impact of Herpes simplex virus (HSV) with severe SARS-CoV-2 infections primarily on mortality, secondarily hospital-acquired pneumonia/ventilator-associated pneumonia (HAP/VAP) intensive care unit-bloodstream infection (ICU-BSI). Methods We conducted an observational study using prospectively collected...
<h3>Importance</h3> Current guidelines recommend brain magnetic resonance imaging (MRI) for clinical management of patients with severe herpes simplex encephalitis (HSE). However, the prognostic value has not been demonstrated in this setting. <h3>Objective</h3> To investigate association between early MRI data and functional outcomes HSE at 90 days after intensive care unit (ICU) admission. <h3>Design, Setting, Participants</h3> This multicenter cohort study was conducted 34 ICUs France...
Rationale: Long-term outcomes of patients with coronavirus disease (COVID-19)-related acute respiratory distress syndrome treated extracorporeal membrane oxygenation (ECMO) are unknown. Objectives: To assess physical examination, pulmonary function tests, anxiety, depression, post-traumatic stress disorder and quality life at 6 12 months after ECMO onset. Methods: Multicenter, prospective study in who received for COVID-19 from March to June 2020 survived hospital discharge. Measurements...
Abstract Background Both critically ill patients with coronavirus disease 2019 (COVID-19) and receiving extracorporeal membrane oxygenation (ECMO) support exhibit a high incidence of healthcare-associated infections (HAI). However, data on incidence, microbiology, resistance patterns, the impact HAI outcomes in ECMO for severe COVID-19 remain limited. We aimed to report microbiology evaluate ECMO-associated (ECMO-AI) in-hospital mortality. Methods For this study, we analyzed from 701...
Remdesivir has reported efficacy against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in vitro and vivo Drug-drug interactions limit therapeutic options transplant patients. its metabolite GS-441524 are excreted principally urine. In intensive care unit (ICU) settings, which multiple-organ dysfunctions can occur rapidly, hemodialysis may be a viable option for maintaining remdesivir treatment, while improving tolerance, by removing both remdesivir's (GS-441524)...
OBJECTIVES: To describe the prevalence, associated factors, and clinical impact of an initial negative herpes simplex virus (HSV) polymerase chain reaction (PCR) in critically ill patients with PCR-proven HSV encephalitis. DESIGN: Retrospective multicenter study from 2007 to 2017. SETTING: Forty-seven French ICUs. PATIENTS: Critically admitted ICU possible/probable acute encephalitis a positive cerebrospinal fluid (CSF) PCR for HSV. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: We...
Augmented renal clearance (ARC) remains poorly evaluated in ICU. The objective of this study is to provide a full description ARC ICU including prevalence, evolution profile, risk factors and outcomes. This was retrospective, single-center, observational study. All the patients older than 18 years admitted for first time Medical ICU, Bichat, University Hospital, APHP, France, between January 1, 2017, November 31, 2020 included into Outcomerea database with an length stay longer 72 h were...
New diagnostic tools have been developed to improve the diagnosis of infectious encephalitis. Using a prospective cohort encephalitis patients, our objective was identify possible clusters patients with similar patterns among unknown cause (EUC) and describe what extent patient's initial presentation may be predictive etiology, particularly herpes simplex virus (HSV) varicella-zoster (VZV).The National Cohort Infectious Encephalitis in France is an ongoing study implemented 2016. Patients...
To describe 3-6-month neurologic outcomes of survivors COVID-19-associated acute respiratory distress syndrome, invasively ventilated in the ICU.A bicentric prospective study during two first waves pandemic (March to May and September December, 2020).Two academic hospital ICUs, Paris, France.Adult syndrome survivors, ICU, were eligible for a consultation between 3 6 months post ICU discharge.Follow-up by face-to-face consultation.The primary endpoint was favorable functional outcome defined...
Increased blood fibrocytes are associated with a poor prognosis in fibrotic lung diseases. We aimed to determine whether the percentage of circulating could be predictive severity and during coronavirus disease 2019 (COVID-19) pneumonia. Blood were quantified by flow cytometry as CD45 + /CD15 − /CD34 /collagen-1 cells patients hospitalized for COVID-19 In subgroup admitted an intensive care unit (ICU), bronchoalveolar lavage (BAL). Serum amyloid P (SAP), transforming growth factor-β1...
Abstract Background Electroencephalography (EEG) is recommended for the practical approach to diagnosis and prognosis of encephalitis. We aimed investigate prognostic value standard EEG ( std EEG) in adult patients with severe herpes simplex Methods performed a retrospective analysis consecutive ICU encephalitis 38 French centers between 2006 2016. Patients at least one study admission were included. findings reviewed independently by two investigators. The association (i.e., background...
Abstract Background The combination lopinavir/ritonavir is recommended to treat HIV-infected patients at the dose regimen of 400/100 mg q12h, oral route. usual lopinavir trough plasma concentrations are 3000–8000 ng/mL. A trend towards a 28 day mortality reduction was observed in COVID-19-infected treated with lopinavir/ritonavir. Objectives To assess and ritonavir severe COVID-19 infection receiving Patients methods Mechanically ventilated included French cohort were included....
Mid-regional proadrenomedullin (MR-proADM) protects against endothelial permeability and has been associated with prognosis in bacterial sepsis. As dysfunction is central the pathophysiology of severe SARS-CoV-2 infection, we sought to evaluate MR-proADM both as a prognostic biomarker marker superinfection. Consecutive patients admitted ICU for pneumonia were prospectively included serum was bio-banked on days 1, 3, 7. levels measured blindly from clinical outcomes batches at end follow-up....
Abstract Background EEG-based prognostication studies in intensive care units often rely on a standard 21-electrode montage ( std EEG) requiring substantial human, technical, and financial resources. We here evaluate whether simplified 4-frontal electrode 4-front can detect EEG patterns associated with poor outcomes adult patients under veno-arterial extracorporeal membrane oxygenation (VA-ECMO). Methods conducted reanalysis of data from prospective cohort 118 VA-ECMO, whom was performed...