A5062125057- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Cardiac Valve Diseases and Treatments
- Transplantation: Methods and Outcomes
- Cardiac Arrest and Resuscitation
- Infective Endocarditis Diagnosis and Management
- Aortic Disease and Treatment Approaches
- Viral Infections and Immunology Research
- Renal Transplantation Outcomes and Treatments
- Cardiac pacing and defibrillation studies
- Aortic aneurysm repair treatments
- Cardiac and Coronary Surgery Techniques
- Cardiac, Anesthesia and Surgical Outcomes
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Organ Transplantation Techniques and Outcomes
- Respiratory Support and Mechanisms
- Heart Failure Treatment and Management
- Organ and Tissue Transplantation Research
- Cardiac Ischemia and Reperfusion
- Cardiovascular Issues in Pregnancy
- Cardiac Arrhythmias and Treatments
- Intensive Care Unit Cognitive Disorders
- Congenital Heart Disease Studies
Pitié-Salpêtrière Hospital
2016-2025
Sorbonne Université
2016-2025
Assistance Publique – Hôpitaux de Paris
2016-2025
Fondation pour l’innovation en Cadiométabolisme et Nutrition
2015-2024
Université Sorbonne Paris Nord
2011-2024
Inserm
2015-2024
Ospedale Policlinico San Martino
2023
University of Genoa
2023
Centre Cardiologique du Nord
2013-2023
Hôpital Charles-Foix
2019-2023
Transcatheter aortic-valve implantation (TAVI) is an emerging intervention for the treatment of high-risk patients with severe aortic stenosis and coexisting illnesses. We report results a prospective multicenter study French national transcatheter registry, FRANCE 2.
To assess the outcomes and long-term quality-of-life of patients supported by extracorporeal membrane oxygenation (ECMO) for refractory cardiogenic shock.Refractory shock is almost always lethal without emergency circulatory support, e.g., ECMO. ECMO-associated morbidity mortality plead identification early predictors its failure, detailed analyses short- to refine patient selection improve results. Outcomes 81 given ECMO support medical (n = 55), postcardiotomy 16), or posttransplantation...
Recent studies have reported a relationship between the abundance of epicardial adipose tissue (EAT) and risk cardiovascular diseases including atrial fibrillation (AF). However, underlying mechanisms are unknown. The aim this study was to examine effects secretome human EAT on histological properties myocardium. Samples subcutaneous (SAT), obtained from 39 patients undergoing coronary bypass surgery, were analysed tested in an organo-culture model rat atria evaluate fibrotic fat depots....
Gilard, Martine; Eltchaninoff, Hélène; Iung,, Bernard; Donzeau-Gouge, Patrick; Chevreul, Karine; Fajadet, Jean; Leprince, Pascal; Leguerrier, Alain; Lievre, Michel; Prat, Teiger, Emmanuel; Lefevre, Thierry; Himbert, Dominique; Tchetche, Didier; Carrié, Albat, Cribier, Rioufol, Gilles; Sudre, Arnaud; Blanchard, Collet, Frederic; Dos Santos, Pierre; Meneveau, Nicolas; Tirouvanziam, Ashok; Caussin, Christophe; Guyon, Philippe; Boschat, Jacques; Le Breton, Herve; Collart, Houel, Remi; Delpine,...
Incidence and impact on adult patients' outcomes of nosocomial infections (NIs) occurring during venoarterial extracorporeal membrane oxygenation (VA-ECMO) support for refractory cardiogenic shock have rarely been described.We retrospectively reviewed the charts a large series patients who received VA-ECMO in our intensive care unit (ICU) from January 2003 through December 2009. Incidence, types, risk factors, NIs ECMO were analyzed.Among 220 (49 ± 16 years old, simplified acute physiology...
Abstract Introduction Extracorporeal life support (ECLS) has recently shown encouraging results in the resuscitation of in-hospital (IH) refractory cardiac arrest. We assessed use ECLS following out-of-hospital (OH) Methods evaluated 51 consecutive patients who experienced witnessed OH arrest and received automated chest compression upon arrival hospital. Patients with preexisting severe hypothermia IH were excluded. A femorofemoral was set up on admission to hospital by a mobile...
Profound myocardial depression can occur during severe septic shock. Although good outcomes of venoarterial extracorporeal membrane oxygenation-treated children with refractory shock have been reported, little is known about adults' outcomes. This study was designed to assess the and long-term health-related quality-of-life patients supported by oxygenation for cardiac hemodynamic failure shock.A retrospective, single-center, observational a cross-sectional survey quality life Short Form-36...
Temporary circulatory support with extracorporeal membrane oxygenation (ECMO) is often the only alternative for supporting patients refractory cardiogenic shock (RCS). In practice, this strategy limited to a small minority of hospitalized in tertiary-care centres ECMO programs. The cardiac-RESCUE program was designed test feasibility providing distant from specialized centres, RCS remote locations.From January 2005 December 2009, hospitals without facilities throughout Greater Paris area...
Background: Whether early percutaneous tracheotomy in patients who require prolonged mechanical ventilation can shorten duration and lower mortality remains controversial. Objective: To compare the outcomes of severely ill randomly assigned to or intubation. Design: Prospective, randomized, controlled, single-center trial (ClinicalTrials.gov registration number: NCT00347321). Setting: Academic center. Patients: 216 adults requiring 4 more days after cardiac surgery. Intervention: Immediate...
Objective: Myocarditis is a rare disease that may progress rapidly to refractory cardiogenic shock and death. In such situations, emergent initiation of mechanical circulatory assistance the only therapeutic option rescue these dying patients. This study was designed evaluate outcomes, health-related quality life frequencies anxiety, depression posttraumatic stress disorder symptoms in fulminant myocarditis patients rescued by assistance, since major components outcome evaluation after...
Significant postprocedural aortic regurgitation (AR) is observed in 10% to 20% of cases after transcatheter valve replacement (TAVR). The prognostic value and the predictors such a complication balloon-expandable (BE) self-expandable (SE) TAVR remain unclear.TAVR was performed 3195 consecutive patients at 34 hospitals. Postprocedural transthoracic echocardiography 2769 (92%) eligible population, these constituted study group. Median follow-up 306 days (Q1-Q3=178-490). BE SE devices were...
Accumulation of atrial adipose tissue is associated with fibrillation (AF). However, the underlying mechanisms remain poorly understood. We examined relationship between characteristics fatty infiltrates myocardium and history AF. Atrial samples, collected in 92 patients during cardiac surgery a sheep model persistent AF, were subjected to detailed histological analysis. In sections human right subepicardial infiltrations commonly observed majority patients. A clear difference appearance...
In the Île-de-France region (henceforth termed Greater Paris), extracorporeal membrane oxygenation (ECMO) for severe acute respiratory distress syndrome (ARDS) was considered early in COVID-19 pandemic. We report ECMO network organisation and outcomes during first wave of pandemic.In this multicentre cohort study, we present an analysis all adult patients with laboratory-confirmed SARS-CoV-2 infection ARDS requiring who were admitted to 17 Paris intensive care units between March 8 June 3,...
<h3>Objective</h3> Decision making for intervention in symptomatic aortic stenosis should balance the risks of surgery and transcatheter valve implantation (TAVI). We identified factors associated with early mortality after TAVI aimed to develop validate a simple risk score. <h3>Methods</h3> A population 3833 consecutive patients was randomly split into two cohorts comprising 2552 1281 patients, used respectively scoring system predicting 30-day or in-hospital mortality. <h3>Results</h3>...
Human epicardial adipose tissue (EAT) is a visceral and perivascular fat that has been shown to act locally on myocardium, atria, coronary arteries. Its abundance linked artery disease (CAD) atrial fibrillation. However, its physiological function remains highly debated. The aim of this study was determine specific EAT transcriptomic signature, depending anatomical peri-atrial (PA), peri-ventricular (PV), or peri-coronary location. Samples thoracic subcutaneous fat, obtained from 41 patients...
Despite quick implementation of reperfusion therapies, a few patients with high-risk, acute, massive, pulmonary embolism (PE) remain highly hemodynamically unstable. Others have absolute contraindication to receive therapies. Venoarterial-extracorporeal membrane oxygenation (VA-ECMO) might lower their right ventricular overload, improve hemodynamic status, and restore tissue oxygenation. ECMO-related complications 90-day mortality were analyzed for 17 unstable, ECMO-treated, massive PE...