Etienne Canouï
A5028527272- Antibiotic Resistance in Bacteria
- Antibiotics Pharmacokinetics and Efficacy
- COVID-19 Clinical Research Studies
- Antibiotic Use and Resistance
- Infectious Diseases and Tuberculosis
- SARS-CoV-2 and COVID-19 Research
- Bacterial Identification and Susceptibility Testing
- Pneumonia and Respiratory Infections
- Infectious Encephalopathies and Encephalitis
- Herpesvirus Infections and Treatments
- Ocular Infections and Treatments
- COVID-19 and Mental Health
- Orthopedic Infections and Treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- Ocular Diseases and Behçet’s Syndrome
- Antifungal resistance and susceptibility
- HIV Research and Treatment
- Infection Control and Ventilation
- Long-Term Effects of COVID-19
- Pharmacovigilance and Adverse Drug Reactions
- Mycobacterium research and diagnosis
- Influenza Virus Research Studies
- Mosquito-borne diseases and control
- Antimicrobial Resistance in Staphylococcus
- Amoebic Infections and Treatments
Assistance Publique – Hôpitaux de Paris
2016-2025
Maternité Port Royal
2021-2025
Groupe Hospitalier Cochin - Port-Royal, Hôtel-Dieu, Broca - La Collégiale
2017-2024
Hôpital Cochin
2017-2024
Sorbonne Université
2012-2024
Université Paris Cité
2017-2023
Hôpital Beaujon
2015-2023
Pitié-Salpêtrière Hospital
2022
Observatoire de la Côte d’Azur
2022
Hôpital Pasteur
2022
ObjectivesIntestinal carriage with extended spectrum β-lactamase Enterobacteriaceae (ESBL-E) and carbapenemase-producing (CPE) can persist for months. We aimed to evaluate whether oral antibiotics followed by faecal microbiota transplantation (FMT) eradicate intestinal ESBL-E/CPE.MethodsRandomized, open-label, superiority trial in four tertiary-care centres (Geneva (G), Paris (P), Utrecht (U), Tel Aviv (T)). Non-immunocompromised adult patients were randomized 1: 1 either no intervention...
The French National Reference Center for Invasive Mycoses and Antifungals leads an active sustained nationwide surveillance program on probable proven invasive fungal diseases (IFDs) to determine their epidemiology in France. Between 2012 2018, a total of 10,886 IFDs were recorded. incidence increased slightly over time (2.16 2.36/10,000 hospitalization days, P = 0.0562) relation with increase fungemia (1.03 1.19/10,000, 0.0023), while that other remained stable. proportion ≥65-year-old...
Abstract Background The development of chatbot artificial intelligence (AI) has raised major questions about their use in healthcare. We assessed the quality and safety management suggested by Chat Generative Pre-training Transformer 4 (ChatGPT-4) real-life practice for patients with positive blood cultures. Methods Over a 4-week period tertiary care hospital, data from consecutive infectious diseases (ID) consultations first culture were prospectively provided to ChatGPT-4. Data requested...
Abstract Background The optimal duration of antimicrobial therapy for urinary tract infections (UTIs) in men remains controversial. Methods To compare 7 days to 14 total antibiotic treatment febrile UTIs men, this multicenter randomized, double-blind. placebo-controlled noninferiority trial enrolled 282 from 27 centers France. Men were eligible if they had a UTI and urine culture showing single uropathogen. Participants treated with ofloxacin or third-generation cephalosporin at day 1, then...
Abstract Background The 2011 4th European Conference on Infections in Leukemia (ECIL4) guidelines recommend antibiotics de-escalation/discontinuation selected febrile neutropenia (FN) patients. We aimed to assess the impact of an antimicrobial stewardship (AMS) program based these use and clinical outcomes high-risk FN Methods conducted observational study hematology department Cochin University Hospital Paris, France. An ECIL4-based de-escalation discontinuation strategy was implemented...
Human immunodeficiency virus controllers (HICs) form a heterogeneous group of patients with regard to formal definitions, immunologic characteristics, and changes over time in viral load.The HICs undetectable load ([uHICs] ie, for whom had never been detected routine assays; n = 52) were compared 178 blips during the follow up (bHICs). Clinical ultrasensitive HIV-ribonucleic acid (RNA) HIV-deoxyribonucleic (DNA) loads, HIV1-Western blot profiles, immune parameters analyzed.Relative bHICs,...
Healthcare workers (HCWs) have paid a heavy toll during the coronavirus disease 2019 (COVID-19) outbreak. Routes of transmission remain to be fully understood.This prospective study compared 1500-bed adult and 600-bed pediatric setting tertiary-care university hospital located in central Paris. From 24 February until 10 April 2020, all symptomatic HCWs were screened for severe acute respiratory syndrome 2 (SARS-CoV-2) on nasopharyngeal swab. positive questioned their profession, symptoms,...
Objectives. The treatment of long-term intravenous catheter-related bloodstream infections (LTIVC-related BSI) often requires catheter removal or a conservative using intra-catheter locks, with 50-60% success rate. We previously demonstrated the synergistic effect combination gentamicin and EDTA-Na2 against bacterial biofilms. performed phase 1/2 clinical trial to assess tolerance efficacy genta-EDTA-Na2 locks for LTIVC-related BSI. Methods. Prospective study including adult patients...
Abstract Background Excess of acute kidney injury (AKI) secondary to the association vancomycin plus piperacillin is debated. Objectives To detect a signal for an increased risk AKI with and combination compared other vancomycin-based regimens. Methods Using VigiBase, WHO global database individual case safety reports (ICSR) from 1997 2019, we conducted disproportionality analysis comparing reporting cases between different regimens (vancomycin piperacillin, cefepime or meropenem). take into...
New diagnostic tools have been developed to improve the diagnosis of infectious encephalitis. Using a prospective cohort encephalitis patients, our objective was identify possible clusters patients with similar patterns among unknown cause (EUC) and describe what extent patient's initial presentation may be predictive etiology, particularly herpes simplex virus (HSV) varicella-zoster (VZV).The National Cohort Infectious Encephalitis in France is an ongoing study implemented 2016. Patients...
This study aimed at characterizing the pharmacokinetics (PK) of oral levofloxacin in adult patients order to optimize dosing scheme and explore PK/pharmacodynamics (PD) bone joint infections (BJIs).From November 2015 December 2019, all hospitalized Cochin Hospital, treated with who had least one dosage for therapeutic drug monitoring were included. PK was described using non-linear mixed-effect modelling. In a subgroup BJIs, association between PK, MIC isolated pathogen clinical outcome...
Pelvic bone and/or soft tissue sarcoma removal surgeries are associated with a high rate of surgical site infection (SSI). The recommended antibiotic prophylaxis (ABP) duration is 24-48 h. We aimed to assess the impact extended ABP (5 days) on SSI and describe microbiology in pelvic sarcomas.We retrospectively included all consecutive patients who underwent surgery between January 2010 June 2020.We analyzed 146 (45, 31%) or (101, 69%). Sixty (41%) developed SSI. occurred 13/28 (46.4%) group...