A5015331144- Pneumonia and Respiratory Infections
- Antibiotics Pharmacokinetics and Efficacy
- HIV/AIDS drug development and treatment
- Antimicrobial Resistance in Staphylococcus
- Antibiotic Resistance in Bacteria
- HIV Research and Treatment
- Infective Endocarditis Diagnosis and Management
- Antifungal resistance and susceptibility
- HIV-related health complications and treatments
- HIV/AIDS Research and Interventions
- Bacterial Infections and Vaccines
- Streptococcal Infections and Treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- Antibiotic Use and Resistance
- Hepatitis C virus research
- Herpesvirus Infections and Treatments
- COVID-19 Clinical Research Studies
- Nosocomial Infections in ICU
- Infectious Encephalopathies and Encephalitis
- Infectious Diseases and Tuberculosis
- Respiratory viral infections research
- Orthopedic Infections and Treatments
- Long-Term Effects of COVID-19
- Fungal Infections and Studies
- Mosquito-borne diseases and control
Hôpital Pellegrin
2025
Médecins du Monde
2025
Hôpital Paul-Brousse
2025
CHU Dijon Bourgogne
2015-2024
Inserm
1994-2024
Hopitaux Civils de Colmar
2024
Maison des Sciences de l’Homme de Dijon
2008-2023
Shaheed Rajaei Cardiovascular Medical and Research Center
2022
Maria Cecilia Hospital
2022
University of Liège
2019-2022
To study the influence of hepatitis C virus (HCV) co-infection on clinical and immunological evolution HIV-infected patients.A longitudinal individuals with or without HCV infection, identified at Infectious Diseases Department Dijon University Hospital enrolled in a historical cohort, was performed.One hundred nineteen people co-infected 119 matched infected HIV alone were included cohort (median participation time 3 years; range, 2 months to 11.5 years). Clinical progression defined as one...
Abstract Background Although immune modulation is a promising therapeutic avenue in coronavirus disease 2019 (COVID-19), the most relevant targets remain to be found. COVID-19 has peculiar characteristics and outcomes, suggesting unique immunopathogenesis. Methods Thirty-six immunocompetent non-COVID-19 27 patients with severe pneumonia were prospectively enrolled single center, requiring intensive care. Clinical biological (including T cell phenotype function plasma concentrations of 30...
Insulin resistance (IR) in the context of highly active antiretroviral therapy (HAART) is becoming more common HIV-infected patients. Patients with chronic hepatitis C virus (HCV) infection have an increased risk IR and type 2 diabetes mellitus. A cross-sectional study was performed to investigate whether HCV constitutes a factor for HIV-HCV-coinfected patients undergoing HAART. Inclusion criteria were positive viremia sustained increase alanine aminotransferase at least twice normal value....
AbstractPurpose: Adherence to antiretroviral medications is critically important for the success of therapy in patients treated HIV infection. Patient self-report a simple method measure and explore adherence. Even though variety surveys have been developed monitor self-reported adherence, there no standardized instrument that may be used routine clinical practice. The usefulness Medication Questionnaire (PMAQ) was evaluated HIV-infected on protease inhibitor (PI)-containing regimens....
OBJECTIVES--To compare the tolerance, efficacy, and pharmacokinetics of amphotericin deoxycholate (Fungizone) prepared in a parenteral fat emulsion (Intralipid 20%) or glucose HIV patients with candidiasis. DESIGN--Non-blind randomised controlled trial. SETTING--University hospital; tertiary clinical care. PATIENTS--22 positive oral INTERVENTIONS--Amphotericin 1 mg/kg/day given on four consecutive days as one hour infusion dissolved either 5% (amphotericin-glucose) at final concentration 2...
ABSTRACT We report a case of cryptococcosis in which serum enzyme-linked immunosorbent assay (ELISA) for Aspergillus galactomannan was positive, with no evidence aspergillosis. Soluble antigens from 19 Cryptococcus neoformans strains and purified carbohydrates C. capsule were thus assayed the ELISA. Antigens all strains, galactoxylomannan, gave positive reaction, suggesting that galactoxylomannan contains an epitope(s) is cross-reactive galactomannan.
There is currently a lack of consensus for the diagnosis, investigations and treatments acute bacterial prostatitis (AP).The symptoms, 371 inpatients diagnosed with AP were analyzed through retrospective study conducted in four departments - Urology (U), Infectious Diseases (ID), Internal Medicine (IM), Geriatrics (G) two French university hospitals.The cause admission, depended markedly on department admission but not hospital. In U, patients commonly presented bladder outlet obstruction,...
Current recommendations for empirical antimicrobial therapy in spontaneous bacterial peritonitis (SBP) are based on quite old trials. Since microbial epidemiology and the management of patients have changed, whether these still appropriate must be confirmed. An observational study that exhaustively collected clinical biological data associated with positive ascitic fluid cultures was conducted four French university hospitals 2010–2011. Two hundred sixty-eight documented were observed 190...
Infective endocarditis (IE)(1) is a severe condition complicating 10–25% of Staphylococcus aureus bacteremia. Although host-related IE risk factors have been identified, the involvement bacterial features in complication still unclear. We characterized strictly defined and bacteremia isolates searched for discriminant features. S. causing community-acquired, definite native-valve (n = 72) 54) were collected prospectively as part French multicenter cohort. Phenotypic traits previously...
In this study, outcomes of patients with leukocytoclastic vasculitis (LCV) were analyzed focusing on clinical, histopathology and laboratory findings, relapses, survival. Data from cutaneous diagnosed between January 1, 2000, December 31, 2010, at Dijon University Hospital (France) retrospectively reviewed. LCV was defined as perivascular neutrophilic infiltrate, endothelial cell nuclear swelling, extravasation red blood cells, and/or fibrin deposition in vessels. Patients classified...
Debate continues regarding the usefulness and benefits of wide prescription antibiotics in patients hospitalized with coronavirus disease 2019 (COVID-19).
Three methods of adherence to antiretroviral therapy were evaluated for 149 patients infected with human immunodeficiency virus (HIV): plasma level protease inhibitors (PIs), patient self-report, and routine biological parameters associated the use some drugs. Adherence was estimated from a score calculated answers self-administered questionnaire on basis measurement relevant blood levels. Of patients, 112 had virologic response, 122 adequate trough PI Plasma levels outcome significantly...
For some pneumococci the fluoroquinolone MICs are low but mutant prevention concentrations (MPCs) high; this difference defines in vitro selection window (MSW). We investigated vivo bacterial reduction and occurrence of resistant mutants with moxifloxacin (MFX; 400 mg once daily) or levofloxacin (LVX; 500 twice treatments similar to those humans experimental pneumonia due (expPP) exhibiting various MPCs. The MIC/MPC for MFX LVX genotypes were as follows: strain 16089, 0.125/0.125 0.5/0.5...
The efficacy and tolerance of a new amphotericin B lipid emulsion (AmB-IL) in which was diluted solution for parenteral nutrition (Intralipid) assessed fourteen episodes candidaemia occurring neutropenic patients. strains isolated were Candida krusei (nine cases), albicans (three parapsilosis (one case) lusitarnae case). An AmB-IL administered at mean dosage 1·18 mg/kg/day (range 0·73–1·55) 22 days 6–62). Flucytosine added to 12 patients (mean duration 10·6 days). Chills noted only 3/306...
A ten day course of oral penicillin is still recommended for pharyngotonsillitis with the aim eradicating Streptococcus pyogenes and preventing rheumatic fever. However there some evidence that V therapy less satisfactory than in former years. Several explanations have been suggested, including inadequate pharmacokinetic properties, poor patient compliance, tolerance, re-infection carrier state, indirect pathogenicity. In this context we evaluated efficacy third generation cephalosporins. We...
Since anatomopathological lesions of the adrenal gland have been frequently observed at autopsy in AIDS, we investigated glucocorticoid function 63 patients (51 men, 12 women) infected by human immunodeficiency virus (HIV) order to determine incidence and nature any adrenocortical abnormalities various stages HIV infection. The were classified according Centers for Disease Control (CDC) recommendations into group II (asymptomatic; N = 13), III (lymphadenopathy; 27) IV (clinical...
Even though it has been suggested that antiretroviral therapy an impact on severe hypovitaminosis D (SHD) in HIV infected patients, could be speculated the different levels of residual inflammation HAART (Highly Active Anti Retroviral Therapy) contribute to SHD and aggravate bone catabolism these patients.A cross-sectional study was carried out unselected cohort 263 outpatients consulting during Spring 2010. Clinical examinations were performed medical history, food habits, sun exposure...
Limited pharmacokinetics data support dalbavancin long-term use in off-label indications and the optimal dosing regimen is debated. We aimed to describe concentrations an observational retrospective multicentre study.