A5073152545- Orthopedic Infections and Treatments
- Diabetic Foot Ulcer Assessment and Management
- Infectious Diseases and Tuberculosis
- Infective Endocarditis Diagnosis and Management
- Streptococcal Infections and Treatments
- Antimicrobial Resistance in Staphylococcus
- Wound Healing and Treatments
- Surgical site infection prevention
- Tuberculosis Research and Epidemiology
- Total Knee Arthroplasty Outcomes
- Skin Diseases and Diabetes
- Mycobacterium research and diagnosis
- Pneumocystis jirovecii pneumonia detection and treatment
- Bacterial Identification and Susceptibility Testing
- Bacteriophages and microbial interactions
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Bartonella species infections research
- Sepsis Diagnosis and Treatment
- Atrial Fibrillation Management and Outcomes
- Autoimmune and Inflammatory Disorders
- Pressure Ulcer Prevention and Management
- Ocular Infections and Treatments
- Infectious Diseases and Mycology
- Bacillus and Francisella bacterial research
- Blood transfusion and management
University of Geneva
2021-2024
University Hospital of Geneva
2020-2024
Hôpital de la Croix-Rousse
2021-2024
Hospices Civils de Lyon
2021-2024
Hôpital Beau-Séjour
2022-2023
Médecins Sans Frontières
2021
Musée d'Art et d'Histoire
2018
Abstract In contrast to the many reports of successful real-world cases personalized bacteriophage therapy (BT), randomized controlled trials non-personalized products have not produced expected results. Here we present outcomes a retrospective observational analysis first 100 consecutive BT difficult-to-treat infections facilitated by Belgian consortium in 35 hospitals, 29 cities and 12 countries during period from 1 January 2008 30 April 2022. We assessed how often positive clinical...
In patients with diabetic foot osteomyelitis (DFO) who underwent surgical debridement, we investigated whether a short (3 weeks) duration compared long (6 of systemic antibiotic treatment is associated noninferior results for clinical remission and adverse events (AEs).In this prospective, randomized, noninferiority pilot trial, randomized (allocation 1:1) DFO after debridement to either 3-week or 6-week course therapy. The minimal follow-up the end therapy was 2 months. We outcomes using...
Abstract Background High-dose daptomycin is increasingly used in patients with bone and joint infection (BJI). This raises concerns about a higher risk of adverse events (AEs), including daptomycin-induced eosinophilic pneumonia (DIEP) myotoxicity. We aimed to examine pharmacokinetic other potential determinants DIEP myotoxicity BJI receiving daptomycin. Methods All for were identified prospective cohort study. Cases matched at 1:3 ratio, controls randomly selected from the same cohort....
Background: The optimal duration of antibiotic therapy for soft-tissue infections the diabetic foot remains unknown. Objective: We determine if after debridement a short (10 days), compared with long (20 results in similar rates clinical remission and adverse events (AE). Summary Background Data: systemic therapy, successful debridement, soft tissue patients is Because high recurrence risk, overuse commonplace. Methods: This was randomized, controlled, non-inferiority pilot trial cases...
Background Infective endocarditis (IE) is a rare and life-threatening condition with considerable mortality rates. Diagnosis often complicated by negative blood culture results, limiting the accurate identification of causative pathogens. This study aimed to evaluate effectiveness metagenomic next-generation sequencing (mNGS) cardiac valve specimens compared conventional clinical laboratory methods for identifying pathogens in IE. Methods Nineteen patients suspected IE who were scheduled...
Daptomycin is increasingly used in the treatment of bone and joint infections (BJIs) may be responsible for daptomycin-induced eosinophilic pneumonia (DIEP), a potentially severe adverse drug reaction. The aim this study was to describe DIEP patients treated at referral center management BJI, revisit current definitions disease.Patients from 1 January 2012 31 March 2021 were included prospective cohort (NCT02817711), which all potential serious events are prospectively recorded. Patients...
Abstract A prospective cohort study was conducted to evaluate long-term safety of tedizolid as suppressive antimicrobial treatment in patients with implant-associated bone and joint infection caused by multidrug-resistant gram-positive pathogens. Seventeen received a median duration 6 months. No developed serious adverse event.
Clinicians frequently monitor serum C-reactive protein (CRP) levels during therapy for diabetic foot infections (DFIs), but evidence supporting this is unclear. Using a database from prospective controlled DFI trials, with fixed duration of antibiotic therapy, we correlated the CRP at study enrolment and end (EOT). Among 159 episodes, 93 involved bone 66 soft tissues. Overall, treatment cured 122 (77%), while 37 episodes (23%) recurred after median 53 days. The in groups cure versus failure...
Primary and revision arthroplasties are increasing worldwide, as periprosthetic joint infections (PJI). The management of PJI requires surgery, the strategy which is dictated by acute or chronic nature infection, with an exchange implant in event a case recurrence same pathogen. We report 63-year-old man two episodes Streptococcus dysgalactiae subsp. equisimilis within 9 months. Based on clinical suspicion haematogenous PJI, patient was treated DAIR (debridement, antibiotics, retention),...
Abstract. Introduction: Costs related to bone and joint infection (BJI) management are increasing worldwide, particularly due the growing use of off-label antibiotics that expensive treatments (ETs), in conjunction with incidence multi-drug-resistant pathogens. The aim this study was evaluate whole costs these during patient route, including those attributed rehabilitation centre (RC) stay one regional referral France. total annual cost ETs for managing complex BJIs France then estimated....
Bone and joint infection (BJI) epidemiology outcomes in solid organ transplant recipients (SOTr) remain largely unknown. We aim to describe BJI a multi-center cohort of SOTr (Swiss Transplant Cohort Study). All consecutive with (01.05.2008-31.12.2019) were included. A nested case-control study identify risk factors for was performed. Among 4482 patients, 61 82 included, at an incidence 1.4% (95% CI 1.1-1.7), higher heart kidney-pancreas (Gray's test p < .01). Although predominately late...
This article highlights four recent updates in infectious disease the management of bone and joint infections (BJI). During first six weeks treatment a BJI, with or without orthopedic implant, oral antimicrobial therapy is as effective intravenous therapy. For periprosthetic infections, randomized control study failed to demonstrate non-inferiority 6 versus 12 antibiotic In diabetic foot osteomyelitis, 3-week course antibiotics appears be non-inferior 6-week course. Phage seems promising...
Laser assisted in situ keratomileusis (LASIK) surgery is the leading and most performed refractive nowadays. A possible complication of LASIK infectious keratitis which can lead to disastrous corneal damage result permanent loss vision. procedures have become increasingly accessible, demand for has risen among patients, challenging medical field improve prevention post-operative infections. Nevertheless, a wide range pathogens been described as responsible post-LASIK keratitis. However,...
Wound healing issues are not rare after total knee arthroplasty. While most patients heal with local wound care, a minority is susceptible to develop serious complications such as peri-prosthetic joint infection. If direct closure feasible, we recommend multidisciplinary approach based on the ortho-plastic model determine optimal strategy. Negative pressure therapy can be used while waiting for definitive coverage optimise environment. Medial gastrocnemius flap considered gold standard...