A5080647333- Orthopedic Infections and Treatments
- Bone fractures and treatments
- Hip and Femur Fractures
- Surgical site infection prevention
- Infectious Diseases and Tuberculosis
- Bacteriophages and microbial interactions
- Orthopaedic implants and arthroplasty
- Microbial infections and disease research
- Pelvic and Acetabular Injuries
- Trauma and Emergency Care Studies
- Vascular Procedures and Complications
- Hematological disorders and diagnostics
- Total Knee Arthroplasty Outcomes
- Infectious Aortic and Vascular Conditions
- Orthopedic Surgery and Rehabilitation
- Abdominal Trauma and Injuries
- Antimicrobial Resistance in Staphylococcus
- Bacterial Identification and Susceptibility Testing
- Aortic aneurysm repair treatments
- Sports injuries and prevention
- Viral Infections and Outbreaks Research
- Cardiac, Anesthesia and Surgical Outcomes
- Musculoskeletal Disorders and Rehabilitation
- Bacterial biofilms and quorum sensing
- Shoulder and Clavicle Injuries
KU Leuven
2016-2025
Universitair Ziekenhuis Leuven
2015-2024
AO Foundation
2015-2018
AZ Sint-Lucas
2010
Fracture-related infection (FRI) is a severe complication after bone injury and can pose serious diagnostic challenge. Overall, there limited amount of scientific evidence regarding criteria for FRI. For this reason, the AO Foundation European Bone Joint Infection Society proposed consensus definition FRI to standardize improve quality patient care applicability future studies condition. The aim article was summarize available provide recommendations diagnosis purpose, will be discussed...
Fracture-related infection (FRI) remains a challenging complication that creates heavy burden for orthopaedic trauma patients, their families and treating physicians, as well healthcare systems. Standardization of the diagnosis FRI has been poor, which made undertaking comparison studies difficult. Recently, consensus definition based on diagnostic criteria was published. As well-established is first step in treatment process FRI, such should not only improve quality published reports but...
Abstract In contrast to the many reports of successful real-world cases personalized bacteriophage therapy (BT), randomized controlled trials non-personalized products have not produced expected results. Here we present outcomes a retrospective observational analysis first 100 consecutive BT difficult-to-treat infections facilitated by Belgian consortium in 35 hospitals, 29 cities and 12 countries during period from 1 January 2008 30 April 2022. We assessed how often positive clinical...
Orthopaedic and trauma device-related infection (ODRI) remains one of the major complications in modern orthopaedic surgery. Despite best practice medical surgical management, neither prophylaxis nor treatment ODRI is effective all cases, leading to infections that negatively impact clinical outcome significantly increase healthcare expenditure. The following review summarises microbiological profile ODRI, antibiotic resistance has on outcomes, some principles weaknesses current systemic...
Bacteriophage therapy has recently attracted increased interest, particularly in difficult-to-treat infections. Although it is not a novel concept, standardized treatment guidelines are currently lacking. We present the first steps towards establishment of "multidisciplinary phage task force" (MPTF) and pathway, based on our experience four patients with severe musculoskeletal After review their medical history current clinical status, multidisciplinary team found infections eligible for...
As well as debridement and irrigation, soft-tissue coverage, osseous stabilization, systemic antibiotic prophylaxis is considered the benchmark in management of open fractures considerably reduces risk subsequent fracture-related infections (FRI). The direct application antibiotics surgical field (local antibiotics) has been used for decades additional fractures, although definitive evidence confirming a beneficial effect scarce. purpose present study was to review clinical regarding...
Fracture-related infection (FRI) is a major complication in musculoskeletal trauma and one of the leading causes morbidity. Standardization general treatment strategies for FRI has been poor. One reasons heterogeneity this patient population, including various anatomical locations, multiple fracture patterns, different degrees soft-tissue injury, conditions. This variability makes complex hard to standardize. As these infections are biofilm-related, surgery remains cornerstone treatment,...
This study aimed to investigate the role of quantitative histological analysis in diagnosis fracture-related infection (FRI).The clinical features, microbiology culture results, and 156 surgically treated nonunions were used stratify likelihood associated infection. There 64 confirmed infected (one or more confirmatory criteria: pus, sinus, bacterial growth two samples), 66 aseptic (no criteria), 26 possibly (pathogen identified from a single specimen no criteria). The inflammatory response...
Abstract Antibiotic‐loaded bone cement (ALBC) is broadly used to treat orthopaedic infections based on the rationale that high‐dose local delivery essential eradicate biofilm‐associated bacteria. However, ALBC formulations are empirically drug susceptibility from routine laboratory testing, which known have limited clinical relevance for biofilms. There also dosing concerns with nonstandardized, surgeon‐directed, hand‐mixed formulations, unknown release kinetics. On basis of our knowledge in...