A5047650052- Orthopedic Infections and Treatments
- Orthopaedic implants and arthroplasty
- Infectious Diseases and Tuberculosis
- Total Knee Arthroplasty Outcomes
- Bone fractures and treatments
- Surgical site infection prevention
- Infective Endocarditis Diagnosis and Management
- Pelvic and Acetabular Injuries
- Hip and Femur Fractures
- Orthopedic Surgery and Rehabilitation
- Streptococcal Infections and Treatments
- Musculoskeletal Disorders and Rehabilitation
- Diabetic Foot Ulcer Assessment and Management
- thermodynamics and calorimetric analyses
- Cardiac, Anesthesia and Surgical Outcomes
- Osteomyelitis and Bone Disorders Research
- Shoulder Injury and Treatment
- Hematological disorders and diagnostics
- Elbow and Forearm Trauma Treatment
- Musculoskeletal pain and rehabilitation
- Bacterial Identification and Susceptibility Testing
- Trauma and Emergency Care Studies
- Hip disorders and treatments
- Spine and Intervertebral Disc Pathology
- Stroke Rehabilitation and Recovery
University of Lausanne
2014-2023
Orthopedic One
2023
University Hospital of Lausanne
2006-2021
Hôpital Orthopédique de la Suisse Romande
2003-2020
KU Leuven
2019
Countess of Chester Hospital NHS Foundation Trust
2015
Cornell University
2006
Hospital for Special Surgery
2004
Amsterdam UMC Location University of Amsterdam
2004
Fracture-related infection (FRI) remains a challenging complication that creates heavy burden for orthopaedic trauma patients, their families and treating physicians, as well healthcare systems. Standardization of the diagnosis FRI has been poor, which made undertaking comparison studies difficult. Recently, consensus definition based on diagnostic criteria was published. As well-established is first step in treatment process FRI, such should not only improve quality published reports but...
For the diagnosis of prosthetic joint infection, real evidence-based guidelines to aid clinicians in choosing most accurate diagnostic strategy are lacking. To address this need, we performed a multidisciplinary systematic review relevant nuclear medicine, radiological, orthopaedic, infectious, and microbiological literature define accuracy each technique provide answers on uniform statements for topic that was found be important develop commonly agreed upon flowchart. The approach used...
Limited antimicrobial agents are available for the treatment of implant-associated infections caused by fluoroquinolone-resistant Gram-negative bacilli. We compared activities fosfomycin, tigecycline, colistin, and gentamicin (alone in combination) against a CTX-M15-producing strain Escherichia coli (Bj HDE-1) vitro foreign-body infection model. The MIC minimal bactericidal concentration logarithmic phase (MBC(log)) stationary (MBC(stat)) were 0.12, 8 μg/ml 0.25, 32, 32 0.5, 2 2, 8, 16...
In adults with a suspicion of peripheral bone infection, evidence-based guidelines in choosing the most accurate diagnostic strategy are lacking.To provide an evidence-based, multidisciplinary consensus document on management adult patients PBIs, we performed systematic review relevant infectious, microbiological, orthopedic, radiological, and nuclear medicine literature. Delegates from four European societies (European Bone Joint Infection Society, Society Microbiology Infectious Diseases,...
Abstract. Background: There is a constant increase of joint arthroplasties to improve the quality life an ever-aging population. Although prosthetic-joint infections are rare, with incidence 1-2%, they represent serious complication in terms morbidity and mortality. Infection related mortality known be approaching 8% at one year. The aim this retrospective study reassess two-year over last ten years.Methods: Patients treated for prosthetic infection University Hospital Lausanne (Switzerland)...
Proper and rapid diagnosis of orthopedic device-related infection is important for successful treatment. Sonication has been shown to improve the diagnostic performance. We hypothesized that combination sonication with a novel method called microcalorimetry will further accelerate implant infection. prospectively included 39 consecutive patients (mean age 59 years, 62% males) at our institution from whom 29 prostheses 10 osteosynthesis material were explanted. The explanted device was...
We investigated the activities of fluconazole, caspofungin, anidulafungin, and amphotericin B against Candida species in planktonic form biofilms using a highly sensitive assay measuring growth-related heat production (microcalorimetry). C. albicans, glabrata, krusei, parapsilosis were tested, MICs determined by broth microdilution method. The antifungal isothermal microcalorimetry at 37°C RPMI 1640. For Candida, flow was measured presence dilutions for 24 h. biofilm formed on porous glass...
With improved diagnostic methods and longer prosthesis indwelling time, the frequency of diagnosed Propionibacterium prosthetic joint infections (PJI) is increasing. Data on clinical, microbiological, radiological surgical treatment are limited, importance this organism in PJI probably underestimated.We retrospectively analyzed patients with caused by spp. at our institution between 2000 2012. Patient data were retrieved through chart review, outcome was evaluated patient follow-up visits.Of...
Hip fracture causes moderate to severe pain and while fascia iliaca block has been reported provide analgesic benefit, most previous trials were unblinded, with subsequent high risks of performance, selection detection biases. In this randomized, control double-blind trial, we tested the hypothesis that a provides effective analgesia for patients suffering from hip fracture.