Annabelle Stoclin
A5020450047- COVID-19 Clinical Research Studies
- Intensive Care Unit Cognitive Disorders
- Respiratory Support and Mechanisms
- Long-Term Effects of COVID-19
- Sepsis Diagnosis and Treatment
- COVID-19 and healthcare impacts
- SARS-CoV-2 and COVID-19 Research
- Family and Patient Care in Intensive Care Units
- Pneumonia and Respiratory Infections
- Nosocomial Infections in ICU
- Neutropenia and Cancer Infections
- Diabetes and associated disorders
- Intraperitoneal and Appendiceal Malignancies
- Cardiac Arrest and Resuscitation
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Anesthesia and Sedative Agents
- Infectious Encephalopathies and Encephalitis
- COVID-19 diagnosis using AI
- Pneumocystis jirovecii pneumonia detection and treatment
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- Cancer Immunotherapy and Biomarkers
- Vascular Anomalies and Treatments
- Healthcare Decision-Making and Restraints
- Acute Myeloid Leukemia Research
Institut Gustave Roussy
2015-2024
Université Paris-Saclay
2018-2023
Centre Hospitalier de Versailles
2022-2023
Inserm
2013-2023
Centre de recherche en Epidémiologie et Santé des Populations
2023
Université de Versailles Saint-Quentin-en-Yvelines
2023
Authorised Association Consortium
2021
Collaborative Group (United States)
2020
Université Paris-Sud
2013-2016
Hôpital Tenon
2007-2015
The excision repair cross-complementation group 1 (ERCC1) protein is a potential prognostic biomarker of the efficacy cisplatin-based chemotherapy in non–small-cell lung cancer (NSCLC). Although several ongoing trials are evaluating level expression ERCC1, no consensus has been reached regarding method for evaluation.
The SARS-COV-2 pandemic has put pressure on intensive care units, so that identifying predictors of disease severity is a priority. We collect 58 clinical and biological variables, chest CT scan data, from 1003 coronavirus-infected patients two French hospitals. train deep learning model based scans to predict severity. then construct the multimodal AI-severity score includes 5 variables (age, sex, oxygenation, urea, platelet) in addition model. show neural network analysis CT-scans brings...
Abstract The circulating metabolome provides a snapshot of the physiological state organism responding to pathogenic challenges. Here we report alterations in plasma reflecting clinical presentation COVID-19 patients with mild (ambulatory) diseases, moderate disease (radiologically confirmed pneumonitis, hospitalization and oxygen therapy), critical (in intensive care). This analysis revealed major disease- stage-associated shifts metabolome, meaning that at least 77 metabolites including...
Objective Few outcome data are available about posterior reversible encephalopathy syndrome (PRES). We studied 90-day functional outcomes and their determinants in patients with severe PRES. Design 70 PRES admitted to 24 ICUs 2001–2010 were included a retrospective cohort study. The main measure was Glasgow Outcome Scale (GOS) of 5 (good recovery) on day 90. Main Results Consciousness impairment the most common clinical sign, occurring 66 (94%) patients. Clinical seizures occurred 57 (81%)...
Patients with cancer are presumed to be at increased risk of severe COVID-19 outcomes due underlying malignancy and treatment-induced immunosuppression. Of the first 178 patients managed for Gustave Roussy Cancer Centre, 125 (70.2%) were hospitalized, 47 (26.4%) developed clinical worsening 31 (17.4%) died. An age over 70 years, smoking status, metastatic disease, cytotoxic chemotherapy an Eastern Cooperative Oncology Group score ≥2 last visit strongest determinants death. In multivariable...
Abstract Background Previous studies reporting the causes of death in patients with severe COVID-19 have provided conflicting results. The objective this study was to describe and timing admitted intensive care unit (ICU). Methods We performed a retrospective eight ICUs across seven French hospitals. All consecutive adult (aged ≥ 18 years) ICU PCR-confirmed SARS-CoV-2 infection acute respiratory failure were included analysis. deaths reported based on medical records. Results From March 1,...
Abstract Background Group A Streptococcus is responsible for severe and potentially lethal invasive conditions requiring intensive care unit (ICU) admission, such as streptococcal toxic shock-like syndrome (STSS). rebound of group (iGAS) infection after COVID-19-associated barrier measures has been observed in children. Several intensivists French adult ICUs have reported similar bedside impressions without objective data. We aimed to compare the incidence iGAS before COVID-19 pandemic,...
The severity of hemoptysis is usually assessed on the amount blood expectorated, although no threshold has been agreed upon. Respiratory or hemodynamic failures are additional criteria but occur in few cases.Early identification in-hospital mortality determinants might be helpful to best characterize severe hemoptysis.This a retrospective cohort study consecutive patients with admitted ICU teaching hospital during 14-year period. model for early prediction was developed derivation sample...
Pneumonia is a dreaded complication of varicella-zoster virus (VZV) infection in adults; however, the data are limited. Our objective was to investigate clinical features, management, and outcomes critically ill patients with VZV-related community-acquired pneumonia (VZV-CAP). This an observational study VZV-CAP admitted 29 intensive care units (ICUs) from January 1996 2015. One hundred two were included. Patients young (age 39 years (interquartile range 32–51)) 53 (52%) immunocompromised....
The aim of this study is to determine whether severe COVID-19 patients harbour a higher risk ICU-acquired pneumonia.This retrospective multicentre cohort comprised all consecutive admitted seven ICUs for pneumonia during the first surge in France. Inclusion criteria were laboratory-confirmed SARS-CoV-2 infection and requirement invasive mechanical ventilation 48 h or more. Control groups two historical cohorts mechanically ventilated ICU bacterial non-SARS-CoV-2 viral pneumonia. outcome...
<h3>Importance</h3> Current guidelines recommend brain magnetic resonance imaging (MRI) for clinical management of patients with severe herpes simplex encephalitis (HSE). However, the prognostic value has not been demonstrated in this setting. <h3>Objective</h3> To investigate association between early MRI data and functional outcomes HSE at 90 days after intensive care unit (ICU) admission. <h3>Design, Setting, Participants</h3> This multicenter cohort study was conducted 34 ICUs France...
Patients with cancer are at higher risk of severe coronavirus infectious disease 2019 (COVID-19), but the mechanisms underlying virus-host interactions during therapies remain elusive. When comparing nasopharyngeal swabs from and noncancer patients for RT-qPCR cycle thresholds measuring acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in 1063 (58% cancer), we found that malignant favors magnitude duration viral RNA shedding concomitant prolonged serum elevations type 1 IFN...
Fifteen percent of patients with cancer experience symptomatic sequelae, which impair post-COVID-19 outcomes. In this study, we investigated whether a proinflammatory status is associated the development COVID-19 sequelae.
ERCC1 (excision repair cross-complementation group 1) plays essential roles in the removal of DNA intrastrand crosslinks by nucleotide excision repair, and that interstrand Fanconi anemia (FA) pathway homology-directed processes (HDR). The function thus impacts on damage response (DDR), particularly anticancer therapy when damaging agents are employed. expression has been proposed as a predictive biomarker to platinum-based therapy. However, assessment clinical samples is complicated...
Abstract Background Immune checkpoint inhibitors have reshaped the standard of care in oncology. However, they been associated with potentially life-threatening immune-related adverse events. With growing indications immune and their position as a pillar cancer treatment, intensive physicians will be increasingly confronted side effects. The outcome patients severe events unit remains unknown. This retrospective multicentric study aims to describe characteristics admitted units 4 academic...
Abstract Background: The SARS-CoV-2 outbreak in Paris’ region significantly affected Gustave Roussy cancer center. Here, we report the experience during outbreak. This has led to a rapid reorganization of patients’ (pts) management, with two concurrent objectives. First, protect pts, who may more severe form disease, from being infected by SARS-CoV-2. Second, pts losing chance receive optimal, if not standard, care. Methods: Cancer suspected infection were admitted at starting March, 12th....