A5038029864- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- Sleep and Wakefulness Research
- Sleep and related disorders
- Respiratory Support and Mechanisms
- Protease and Inhibitor Mechanisms
- Tracheal and airway disorders
- Neonatal Respiratory Health Research
- Cardiovascular Syncope and Autonomic Disorders
- Long-Term Effects of COVID-19
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Peptidase Inhibition and Analysis
- Cardiovascular and Diving-Related Complications
- Restless Legs Syndrome Research
- Heart Rate Variability and Autonomic Control
- COVID-19 and Mental Health
- Blood Coagulation and Thrombosis Mechanisms
- Intensive Care Unit Cognitive Disorders
- Pulmonary Hypertension Research and Treatments
- Heart Failure Treatment and Management
- Dysphagia Assessment and Management
- Circadian rhythm and melatonin
- Cardiac Arrest and Resuscitation
- Asthma and respiratory diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Assistance Publique – Hôpitaux de Paris
2016-2025
Université Paris Cité
2016-2025
Sorbonne Paris Cité
2015-2025
Hôpital Bichat-Claude-Bernard
2016-2025
Inserm
2014-2025
NeuroDiderot
2020-2025
Délégation Paris 7
2015-2024
Université Claude Bernard Lyon 1
2015-2024
Hôtel-Dieu de Paris
2024
Nord University
2024
Central sleep apnea is associated with poor prognosis and death in patients heart failure. Adaptive servo-ventilation a therapy that uses noninvasive ventilator to treat central by delivering servo-controlled inspiratory pressure support on top of expiratory positive airway pressure. We investigated the effects adaptive who had failure reduced ejection fraction predominantly apnea.We randomly assigned 1325 left ventricular 45% or less, an apnea-hypopnea index (AHI) 15 more events...
We have used C-terminal domain mutants to further define the role of interactions progelatinase A and membrane type 1 matrix metalloproteinase (MT1 MMP) in binding TIMP2 cell-associated activation A. Soluble constructs MT1 MMP were demonstrate that with occurs primarily through N-terminal interactions, leaving free for The rate autolytic initiated by cleavage could be potentiated concentration proenzyme heparin. Residues 568–631 are important formation heparin site, since replacement this...
Soluble proenzyme forms of the catalytic domains membrane‐type matrix metalloproteinases 1 and 2 (MT1‐MMP MT2‐MMP) a form MTI‐MMP containing hemopexin were expressed as soluble recombinant proteins. Purified, activated MT‐MMP shown to degrade fibronectin, tenascin, nidogen, aggrecan perlecan. Only MT2‐MMP showed activity against laminin. MT1‐MMP retaining domain was able specifically cleave native type‐I type‐III collagens into 3/4‐1/4 fragments typical specific collagenases. The alone did...
Polymorphonuclear neutrophil (PMN) migration across basement membrane is thought to be dependent on the degradation of constituents. PMN gelatinase B, a metalloproteinase able degrade type IV collagen, may involved in this phenomenon. B released extracellular medium as latent proform and then activated, mainly by elastase. We investigated role Matrigel matrix coated onto filter, Boyden chamber. The effects elastase inhibitors system were tested. Chemokinesis was tested same chamber filter...
An increased incidence of narcolepsy in children was detected Scandinavian countries where pandemic H1N1 influenza ASO3-adjuvanted vaccine used. A campaign vaccination against implemented France using both and non-adjuvanted vaccines. As part a study considering all-type narcolepsy, we investigated the association between with cataplexy adults compared matched controls; phenotype according to exposure vaccination. Patients narcolepsy-cataplexy were included from 14 expert centres France....
To assess the performance of automatic sleep scoring software (ASEEGA) based on a single EEG channel comparatively with manual (2 experts) conventional full polysomnograms.
Nasal obstruction has frequently been mentioned as a possible risk factor in obstructive sleep apnoea syndrome (OSAS). Over 2-yr period, 541 unselected consecutive snorers referred for suspected breathing disorders during were included to undergo posterior rhinomanometry. In addition cephalometric landmarks and body mass index (BMI) obtained. Polysomnography was used determine the number of abnormal respiratory events that occurred sleep. OSAS defined 15 episodes, or more, hypopnoea per hour...
We have assessed the effect of fibronectin and laminin-1 on expression molecules involved in activation pathway MMP-2, a key proteinase tissue remodelling. HT1080 fibrosarcoma cells cultured were shown to activate endogenous level comparable with that elicited by treatment phorbol ester. In contrast, MMP-2 expressed was mainly pro- (inactive form). Culture peptide fragments derived from central cell binding domain also promoted activation, indicating signals via integrin receptors may be...
The origins of excessive daytime sleepiness in Parkinson disease (PD) are unclear. authors hypothesize that orexin neurons, a recently identified wake promoting system, could contribute to its pathophysiology. They measured orexin-A/hypocretin-1 concentration ventricular CSF 19 parkinsonian patients and compared it with neurologic controls. Orexin levels were lower decreased the severity disease. suggest neurons late stage PD.
To determine whether sleep quality helps to predict noninvasive ventilation outcome in patients with acute hypercapnic respiratory failure. Despite an initial clinical improvement, nearly one fourth of may fail after several days. Because late intubation is associated a poor prognosis, it be useful identify factors that or explain failure.We prospectively studied 27 medical intensive care unit who required for >48 hrs.A 17-hr polysomnography (3 PM-8 AM) was recorded 2 days 4 initiation. Late...
Objectives: To compare the influence of three ventilatory modes on sleep. Design: Prospective, comparative, crossover study. Setting: Medical intensive care unit in a university hospital. Patients: Fifteen conscious, nonsedated, mechanically ventilated patients. Interventions: Patients were successively with assist-control ventilation, clinically adjusted pressure support ventilation (cPSV), and automatically (aPSV). Sleep polysomnography was performed during consecutive 6-hr periods, one...
Central sleep apnoea/Cheyne-Stokes respiration (CSA/CSR) is a risk factor for increased mortality and morbidity in heart failure (HF). Adaptive servo-ventilation (ASV) non-invasive ventilation modality the treatment of CSA/CSR patients with HF.SERVE-HF multinational, multicentre, randomized, parallel trial designed to assess effects addition ASV (PaceWave, AutoSet CS; ResMed) optimal medical management compared alone (control group) symptomatic chronic HF, LVEF ≤45%, predominant CSA. The...
Since the outbreak of coronavirus (COVID-19) pandemic, most attention has focused on containing transmission and addressing surge critically ill patients in acute care settings. As we enter second phase emphasis must evolve to post-acute COVID-19 survivors. Persisting cardiorespiratory symptoms have been reported at several months after onset infection. Information is lacking pathophysiology exercise intolerance COVID-19. Previous outbreaks coronaviruses associated with persistent dyspnea,...
Background Obstructive sleep apnoea (OSA) is associated with increased morbidity and mortality. Although the disorder has been well studied in selected high-risk populations, few data exist on its prevalence general population. We aimed to assess determinants of OSA France. Methods Data from participants French population-based CONSTANCES cohort aged 18–69 years at inclusion being treated for or screened 2017 using Berlin Questionnaire were analysed. Weighted analyses performed provide...
This multi-center comparative cross-sectional study aimed to describe educational and occupational pathways, quantify effort/reward imbalance at work identify factors associated with professional prognosis in patients narcolepsy type 1 (NT1). Adult NT1 controls answered online questionnaires (Epworth sleepiness Scale, Beck Depression Inventory II, Siegrist questionnaire, Self-Report, a questionnaire on academic trajectories) were compared using sex- age-adjusted logistic regressions....
SW1353 chondrosarcoma cells cultured in the presence of interleukin-1, concanavalin A or PMA secreted procollagenase 3 (matrix metalloproteinase-13). The enzyme was detected culture medium by Western blotting using a specific polyclonal antibody raised against recombinant human 3. Oncostatin M enhanced interleukin-1-induced production 3, whereas interleukin-4 decreased synthesis. latent except when had been treated with A, processed form 48 kDa, which corresponds to active form, found and...
Pulmonary arterial hypertension (PAH) results from persistent vasoconstriction, smooth muscle growth and extracellular matrix (ECM) remodelling of pulmonary arteries (PAs). Matrix metalloproteinases (MMPs) are matrix-degrading enzymes involved in ECM turnover, cell (SMC) endothelial migration proliferation. MMP expression activity increased experimental PAH. Therefore, this study investigated whether similar changes occur idiopathic PAH (IPAH; formerly known as primary hypertension). Both...
The objectives of this prospective study were: 1) to determine the prevalence and determinants obstructive sleep apnoea (OSA) in patients with newly diagnosed idiopathic pulmonary fibrosis (IPF); 2) whether OSA was associated cardiovascular disease (CVD) as well increased oxidative stress levels IPF biomarkers blood.A group 45 attended polysomnography. CVD severity coronary artery calcification were investigated by high-resolution computed tomography. 8-hydroxydeoxyguanosine (8-OH-DG)...