A5040199451- Neuroscience of respiration and sleep
- Sleep and Wakefulness Research
- Sleep and related disorders
- Obstructive Sleep Apnea Research
- Infant Health and Development
- Neonatal and fetal brain pathology
- Neonatal Respiratory Health Research
- Heart Rate Variability and Autonomic Control
- Infant Development and Preterm Care
- Child Nutrition and Feeding Issues
- Restless Legs Syndrome Research
- Psychoanalysis and Psychopathology Research
- Circadian rhythm and melatonin
- Tracheal and airway disorders
- Children's Physical and Motor Development
- Attention Deficit Hyperactivity Disorder
- Restraint-Related Deaths
- Sleep and Work-Related Fatigue
- Health, Medicine and Society
- Respiratory Support and Mechanisms
- Airway Management and Intubation Techniques
- Early Childhood Education and Development
- Genetics and Neurodevelopmental Disorders
- Child Development and Digital Technology
- Cognitive and developmental aspects of mathematical skills
Centre de Recherche en Neurosciences de Lyon
2016-2025
Hospices Civils de Lyon
2016-2025
Université Claude Bernard Lyon 1
2016-2025
Inserm
2016-2025
Centre National de la Recherche Scientifique
2016-2025
Hospital Pablo Tobon Uribe
2025
Hôpital Femme Mère Enfant
2015-2024
Centre Hospitalier Le Vinatier
2018-2024
Hôpital Mère-Enfant
2008-2024
Hospital Quirón Teknon
2023
An increased incidence of narcolepsy in children was detected Scandinavian countries where pandemic H1N1 influenza ASO3-adjuvanted vaccine used. A campaign vaccination against implemented France using both and non-adjuvanted vaccines. As part a study considering all-type narcolepsy, we investigated the association between with cataplexy adults compared matched controls; phenotype according to exposure vaccination. Patients narcolepsy-cataplexy were included from 14 expert centres France....
This multi-center comparative cross-sectional study aimed to describe educational and occupational pathways, quantify effort/reward imbalance at work identify factors associated with professional prognosis in patients narcolepsy type 1 (NT1). Adult NT1 controls answered online questionnaires (Epworth sleepiness Scale, Beck Depression Inventory II, Siegrist questionnaire, Self-Report, a questionnaire on academic trajectories) were compared using sex- age-adjusted logistic regressions....
We studied the polygraphic sleep recordings of 30 infants who eventually died sudden infant death syndrome (SIDS) and those 60 matched control infants. All records were extracted from 20,750 studies collected prospectively in 10 laboratories. Of future SIDS victims, 5 siblings victims 9 after an apparent life-threatening event. For each victim, two normal for sex, gestational age, postnatal age weight at birth. The reported to have more frequent episodes regurgitations feeding (p = 0.01)...
Abstract Objective Kleine–Levin syndrome is a rare disorder characterized by relapsing‐remitting episodes of hypersomnia, cognitive disturbances, and behavioral such as hyperphagia hypersexuality. Methods We collected detailed clinical data blood samples on 108 patients, 79 parent pairs, matched control subjects. measured biological markers typed human leukocyte antigen genes DR DQ. Results Novel predisposing factors were identified including increased birth developmental problems (odds...
To determine the respective role played by orexin/hypocretin and histamine (HA) neurons in maintaining wakefulness (W), we characterized behavioral sleep-wake phenotypes of orexin (Ox) knock-out (-/-) mice compared them with those histidine-decarboxylase (HDC, HA-synthesizing enzyme)-/- mice. While both mouse strains displayed sleep fragmentation increased paradoxical (PS), they presented a number marked differences: (1) PS increase HDC(-/-) was seen during lightness, whereas that Ox(-/-)...
To evaluate the frequency, severity, and associations of symptoms attention-deficit/hyperactivity disorder (ADHD) in children with narcolepsy without cataplexy.Cross-sectional survey.Four French national reference centers for narcolepsy.One hundred eight consecutively referred aged younger than 18 y narcolepsy, (NwC, n = 86) or cataplexy (NwoC, 22), 67 healthy controls.The participants, their families, sleep specialists completed a structured interview questionnaires about sleep, daytime...
Infants who became victims of sudden infant death syndrome (SIDS) aroused less from sleep than control infants. This study was conducted to determine the characteristics arousal infants eventually died SIDS. Sixteen were monitored some days or weeks before they Their polygraphic recordings compared with those matched Arousals scored as subcortical activation (incomplete arousals) cortical (complete arousals). Cortical arousals significantly frequent in would succumb SIDS future during both...
To evaluate the potential relation between body position and sleep characteristics in normal infants.Two groups of 3-month-old healthy infants were evaluated: 40 who usually slept supine, prone. The two matched for gender, gestational age, postnatal birth weight, total recording time. RECORDING TECHNIQUES: 80 studied polygraphically during one night pediatric laboratory. They allowed to fall asleep their usual position, every 3 hours gently turned from prone or supine prone.In each group, 6...
Objective Narcolepsy is a rare disabling sleep disorder characterized by excessive daytime sleepiness and cataplexy (sudden loss of muscle tone). Drugs such as pitolisant, which block histamine H3 autoreceptors, constitute newly identified class stimulants because they increase brain enhance wakefulness in animal human adult narcolepsy. Methods We report our experience with the off-label use pitolisant 4 teenagers narcolepsy/cataplexy severe sleepiness, refractory to available treatments...
Objective Kleine–Levin syndrome is a rare disease characterized by recurrent episodes of hypersomnia with behavioral and cognitive disturbances. We aimed at describing the diagnosis procedure, risk factors, severe forms. Methods In consecutive patients referred for suspected syndrome, we detailed differential diagnoses, atypical secondary cases, compared typical healthy subjects, examined characteristics prolonged (>30 days) episodes. Results Among 166 patients, 120 had primary (syndrome...
Summary Aims To evaluate the impact of obesity on clinical and sleep characteristics in a population narcoleptic children. Methods Data from children diagnosed with idiopathic narcolepsy National Reference Centers for Narcolepsy were collected between 2008 2011. Clinical electrophysiological compared obese (body mass index [ BMI ] greater than P97) nonobese Results The 117 (65 boys, 59 de novo patients) had mean age 11.6 ± 3.1 years diagnosis. Cataplexy was present 81%, DQB 1*0602 91%. Mean...
To evaluate the health-related quality of life (HRQL) and its correlates in children adolescents with narcolepsy.We compared clinical characteristics control subjects patients primary narcolepsy from data collected at National Reference Centers for Narcolepsy.The cohort included 69 (29 boys) 117 (65 boys; 59 de novo patients). Cataplexy was present 81% DQB1*0602 positive 91%. The were older (13.5±3.2 vs. 11.6±3.1 years, P<0.001) less obese (1.4% 60%, P<0.001). Twenty-five percent 15.6% had...
To investigate the effect of prenatal smoking on infant respiratory behavior during sleep.A questionnaire concerning family habits and infants' history was completed for 550 healthy infants before a 9-hour night polysomnographic study. Because data 41 were not available analysis, 509 subjects studied: 115 newborns evaluated within 1 week after birth, 394 admitted at 11 weeks life (range 5 to 29 weeks) various research protocols.According frequency mothers pregnancy, defined as "nonsmokers"...
Objective. To evaluate the relationship between body position during sleep and infants' cardiac responses to auditory stimulation. Methods. Thirty healthy infants with a median age of 11 weeks were studied polygraphically for one night, while sleeping successively prone supine, or vice versa. Their behavioral recorded rapid eye movement (REM) sleep, both before after exposure 90 dB (A) white-noise. Results. Ten excluded from study, because they woke up challenge. For 20 included in analysis,...
Swaddling is an old infant care practice. It was reported to favor sleep and reduce crying among irritable infants. There are few data on the physiologic effects of swaddling infants' sleep-wake characteristics. This study conducted evaluate whether influences arousal thresholds for environmental auditory stress.Sixteen healthy infants, with a median age 10 weeks (range: 6-16 weeks), underwent polygraphic recording in their usual supine position during one night. The infants were...