A5074167675- Mast cells and histamine
- Polyamine Metabolism and Applications
- Asthma and respiratory diseases
- COVID-19 Clinical Research Studies
- Olfactory and Sensory Function Studies
- Circadian rhythm and melatonin
- Long-Term Effects of COVID-19
- Sleep and Wakefulness Research
- Amino Acid Enzymes and Metabolism
- Receptor Mechanisms and Signaling
- Allergic Rhinitis and Sensitization
- Cancer Treatment and Pharmacology
- Contact Dermatitis and Allergies
- Immune Cell Function and Interaction
- COVID-19 and healthcare impacts
- Food Allergy and Anaphylaxis Research
- Chemotherapy-induced cardiotoxicity and mitigation
- Dermatology and Skin Diseases
- Atrial Fibrillation Management and Outcomes
- Epigenetics and DNA Methylation
- Biochemical effects in animals
- Cardiac Arrhythmias and Treatments
- Neuroendocrine regulation and behavior
- Obsessive-Compulsive Spectrum Disorders
- Inhalation and Respiratory Drug Delivery
Juntendo University
2014-2025
National Center for Global Health and Medicine
2016-2025
Waseda University
2020-2025
Juntendo University Hospital
2016-2024
Tokyo University of Science
2023
Centre for Innovation in Regulatory Science
2022
Center for Cancer Research
2022
Center for Global Health
2015-2022
Hyogo Social Welfare Corporation
2018-2021
Tohoku University
2011-2020
The hypothesis that histaminergic neurons are involved in brain arousal is supported by many studies. However, the effects of selective long-term abolition on sleep–wake cycle, indispensable determining their functions, remain unknown. We have compared histamine(HA)-immunoreactivity and cortical-EEG cycle under baseline conditions or after behavioral pharmacological stimuli wild-type (WT) knock-out mice lacking histidine decarboxylase gene (HDC−/−). HDC−/−mice showed an increase paradoxical...
Histidine decarboxylase (HDC) synthesizes histamine from histidine in mammals. To evaluate the role of histamine, we generated HDC‐deficient mice using a gene targeting method. The showed deficiency and lacked histamine‐synthesizing activity histidine. These are viable fertile but exhibit decrease numbers mast cells while remaining show an altered morphology reduced granular content. amounts cell proteases were tremendously reduced. provide unique promising model for studying broad range...
Rationale & ObjectiveEpidemiologic and clinical studies have suggested that urate-lowering therapy may slow the progression of chronic kidney disease (CKD). However, definitive evidence is lacking.Study DesignRandomized, double-blind, placebo-controlled trial.Setting Participants467 patients with stage 3 CKD asymptomatic hyperuricemia at 55 medical institutions in Japan.InterventionParticipants were randomly assigned a 1:1 ratio to receive febuxostat or placebo for 108 weeks.OutcomesThe...
This investigator-initiated, phase 2, single-arm trial primarily assessed the efficacy of G47∆, a triple-mutated, third-generation oncolytic herpes simplex virus type 1, in 19 adult patients with residual or recurrent, supratentorial glioblastoma after radiation therapy and temozolomide (UMIN-CTR Clinical Trial Registry UMIN000015995). G47Δ was administered intratumorally repeatedly for up to six doses. The primary endpoint 1-yr survival rate G47∆ initiation 84.2% (95% confidence interval,...
Current guidelines call for high-intensity statin therapy in patients with cardiovascular disease on the basis of several previous "more versus less statins" trials. However, no clear evidence more statins has been established an Asian population. In this prospective, multicenter, randomized, open-label, blinded end point study, 13 054 Japanese stable coronary artery who achieved low-density lipoprotein cholesterol (LDL-C) <120 mg/dL during a run-in period (pitavastatin 1 mg/d) were...
There is limited understanding of the characteristics patients with coronavirus disease 2019 (COVID-19) requiring hospitalization in Japan.
Abstract Here, we report the results of a phase I/II, single-arm study (UMIN-CTR Clinical Trial Registry UMIN000002661) assessing safety (primary endpoint) G47∆, triple-mutated oncolytic herpes simplex virus type 1, in Japanese adults with recurrent/progressive glioblastoma despite radiation and temozolomide therapies. G47Δ was administered intratumorally at 3 × 10 8 pfu (low dose) or 1 9 (set dose), twice to identical coordinates within 5–14 days. Thirteen patients completed treatment dose,...
Objectives To investigate the risk factors contributing to severity on admission. Additionally, of worst and fatality were studied. Moreover, compared based three points: early severity, fatality. Design An observational cohort study using data entered in a Japan nationwide COVID-19 inpatient registry, COVIREGI-JP. Setting As 28 September 2020, 10480 cases from 802 facilities have been registered. Participating cover wide range hospitals where patients with are admitted Japan. Participants...
The hypocretins (Hcrts) (also called orexins) are two neuropeptides expressed in the lateral hypothalamus that play a crucial role stability of wakefulness. Previously, our laboratory demonstrated vivo photostimulation Hcrt neurons genetically targeted with ChR2, light-activated cation channel, was sufficient to increase probability an awakening event during both slow-wave sleep and rapid eye movement sleep. In current study, we ask whether Hcrt-mediated sleep-to-wake transitions affected by...
To determine the respective role played by orexin/hypocretin and histamine (HA) neurons in maintaining wakefulness (W), we characterized behavioral sleep-wake phenotypes of orexin (Ox) knock-out (-/-) mice compared them with those histidine-decarboxylase (HDC, HA-synthesizing enzyme)-/- mice. While both mouse strains displayed sleep fragmentation increased paradoxical (PS), they presented a number marked differences: (1) PS increase HDC(-/-) was seen during lightness, whereas that Ox(-/-)...
Background Although previous clinical trials demonstrated the non-inferiority of a rate control to rhythm strategy for management atrial fibrillation (AF), optimal treatment paroxysmal AF (PAF) remains unclear. Methods and Results A randomized, multicenter comparison vs in Japanese patients with PAF (the Rhythm Management Trial Atrial Fibrillation (J-RHYTHM) study) was conducted. The primary endpoint composite total mortality, symptomatic cerebral infarction, systemic embolism, major...
Type 2 diabetes (T2D) is a complex, polygenic disease affecting nearly 300 million people worldwide. T2D primarily characterized by insulin resistance, and growing evidence has indicated the causative link between adipose tissue inflammation development of resistance. Genetic association studies have successfully revealed number important genes consistently associated with to date. However, these robust T2D-associated do not fully elucidate mechanisms underlying progression disease. Here, we...
To explore the efficacy and stimulation frequency dependence of repetitive transcranial magnetic (rTMS) over supplementary motor area (SMA) in Parkinson disease (PD).In this randomized, double-blind, sham-controlled, multicenter study with a parallel design, weekly intervention was performed 8 times. The effects were monitored up to 20 weeks. By central registration, participants assigned 1 3 arms study: low-frequency (1-Hz) rTMS, high-frequency (10-Hz) realistic sham stimulation. primary...
Objective To determine whether histamine cells are altered in human narcolepsy with cataplexy and animal models of this disease. Methods Immunohistochemistry for histidine decarboxylase (HDC) quantitative microscopy were used to detect narcoleptics, hypocretin (Hcrt) receptor‐2 mutant dogs, 3 mouse models: Hcrt (orexin) knockouts, ataxin‐3‐orexin, doxycycline‐controlled‐diphtheria‐toxin‐A‐orexin. Results We found an average 64% increase the number neurons cataplexy, no overlap between...
<h3>Importance</h3> The optimal management for acute traumatic cervical spinal cord injury (SCI) is unknown. <h3>Objective</h3> To determine whether early surgical decompression results in better motor recovery than delayed treatment patients with incomplete SCI associated preexisting canal stenosis but without bone injury. <h3>Design, Setting, and Participants</h3> This multicenter randomized clinical trial was conducted 43 tertiary referral centers Japan from December 2011 through November...
Before widespread coronavirus disease (COVID-19) vaccinations, Japan experienced three COVID-19 epidemic waves. This study aimed to evaluate the characteristics of hospitalised patients and reveal temporal changes.
AimsAtrial fibrillation (AF) is a common arrhythmia frequently associated with hypertension. This study was designed to test the hypothesis that lowering blood pressure by angiotensin II-receptor blockers (ARB) has more beneficial effects than conventional calcium channel (CCB) on frequency of paroxysmal AF