A5035391048- Sleep and Wakefulness Research
- Sleep and related disorders
- Respiratory Support and Mechanisms
- Restless Legs Syndrome Research
- Neuroscience of respiration and sleep
- Empathy and Medical Education
- Circadian rhythm and melatonin
- Memory and Neural Mechanisms
- Family and Patient Care in Intensive Care Units
- Neuroscience and Neuropharmacology Research
- Parkinson's Disease Mechanisms and Treatments
- Obstructive Sleep Apnea Research
- Intensive Care Unit Cognitive Disorders
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Olfactory and Sensory Function Studies
- Health, psychology, and well-being
- Music Therapy and Health
- Heart Rate Variability and Autonomic Control
- Pediatric Pain Management Techniques
- Psychoanalysis and Psychopathology Research
- Psychosomatic Disorders and Their Treatments
- Pain Management and Placebo Effect
- Mindfulness and Compassion Interventions
- Non-Invasive Vital Sign Monitoring
- Parkinson's Disease and Spinal Disorders
Inserm
2009-2024
Sorbonne Université
2013-2024
Neurophysiologie respiratoire expérimentale et clinique
2015-2024
Assistance Publique – Hôpitaux de Paris
2013-2024
Pitié-Salpêtrière Hospital
2009-2023
Hôpital Charles-Foix
2017
Université Paris Cité
2009-2017
Institut du Cerveau
2011-2017
Centre National de la Recherche Scientifique
2011-2016
FHU Neurovasc
2016
An increased incidence of narcolepsy in children was detected Scandinavian countries where pandemic H1N1 influenza ASO3-adjuvanted vaccine used. A campaign vaccination against implemented France using both and non-adjuvanted vaccines. As part a study considering all-type narcolepsy, we investigated the association between with cataplexy adults compared matched controls; phenotype according to exposure vaccination. Patients narcolepsy-cataplexy were included from 14 expert centres France....
<b>Objective:</b> To document unusual, nonviolent behaviors during REM sleep behavior disorder (RBD) and evaluate their frequency in Parkinson disease (PD). <b>Background:</b> Most previously described RBD mimic attacks, suggesting they proceed from archaic defense generators the brainstem. Feeding, drinking, sexual behaviors, urination, defecation have not been documented yet RBD. <b>Methods:</b> We collected 24 cases of idiopathic symptomatic (narcolepsy, dementia with Lewy bodies, PD),...
To evaluate the frequency, severity, and associations of symptoms attention-deficit/hyperactivity disorder (ADHD) in children with narcolepsy without cataplexy.Cross-sectional survey.Four French national reference centers for narcolepsy.One hundred eight consecutively referred aged younger than 18 y narcolepsy, (NwC, n = 86) or cataplexy (NwoC, 22), 67 healthy controls.The participants, their families, sleep specialists completed a structured interview questionnaires about sleep, daytime...
Poor sleep is common in intensive care unit (ICU) patients, where environmental factors contribute to reduce and fragment sleep. The objective of this study was evaluate the impact earplugs eye mask on architecture ICU patients. A single-center randomized controlled trial 64 patients conducted from July 2012 December 2013. Patients were randomly assigned with or without an inclusion until discharge. Polysomnography performed first day night following inclusion. primary outcome proportion...
Objective Kleine–Levin syndrome is a rare disease characterized by recurrent episodes of hypersomnia with behavioral and cognitive disturbances. We aimed at describing the diagnosis procedure, risk factors, severe forms. Methods In consecutive patients referred for suspected syndrome, we detailed differential diagnoses, atypical secondary cases, compared typical healthy subjects, examined characteristics prolonged (>30 days) episodes. Results Among 166 patients, 120 had primary (syndrome...
Summary Aims To evaluate the impact of obesity on clinical and sleep characteristics in a population narcoleptic children. Methods Data from children diagnosed with idiopathic narcolepsy National Reference Centers for Narcolepsy were collected between 2008 2011. Clinical electrophysiological compared obese (body mass index [ BMI ] greater than P97) nonobese Results The 117 (65 boys, 59 de novo patients) had mean age 11.6 ± 3.1 years diagnosis. Cataplexy was present 81%, DQB 1*0602 91%. Mean...
Kleine-Levin syndrome is characterized by relapsing-remitting episodes of severe hypersomnia, cognitive impairment, apathy, derealization and behavioural disturbances. Between episodes, patients have normal sleep, mood behaviour. Functional imaging studies performed in small series with visual or semi-quantitative, uncontrolled analysis yielded equivocal brain changes. Using whole voxel-based group analysis, we compared perfusion scintigraphy during between consecutive versus healthy control...
To evaluate the health-related quality of life (HRQL) and its correlates in children adolescents with narcolepsy.We compared clinical characteristics control subjects patients primary narcolepsy from data collected at National Reference Centers for Narcolepsy.The cohort included 69 (29 boys) 117 (65 boys; 59 de novo patients). Cataplexy was present 81% DQB1*0602 positive 91%. The were older (13.5±3.2 vs. 11.6±3.1 years, P<0.001) less obese (1.4% 60%, P<0.001). Twenty-five percent 15.6% had...
Question Dyspnoea persisting despite treatments of underlying causes requires symptomatic approaches. Medical hypnosis could provide relief without the untoward effects pharmacological We addressed this question through experimentally induced dyspnoea in healthy humans (inspiratory threshold loading (excessive inspiratory effort) and carbon dioxide stimulation (air hunger)). Material methods 20 volunteers (10 women, aged 21–40 years) were studied on four separate days. The order visits was...
<h3>Objective:</h3> To compare the benefits and risks of lithium therapy vs abstention/other treatments in Kleine-Levin syndrome (KLS). <h3>Methods:</h3> In a KLS cohort followed single center, 130 patients regularly took carbonate (median dose 1,000 mg/day; n = 71; 40 children), valproate (n 5), contraceptive pill or no treatment 49). The disease characteristics (frequency, mean, longest durations episodes, time incapacitated per year) were compared before after follow-up abstention groups....
In Kleine-Levin syndrome (KLS), episodes of hypersomnia, cognitive, and behavioral disturbances alternate with asymptomatic periods. Because 50% patients report decreased academic performances, we evaluated their cognitive status during periods, determinants deficits, changes follow-up.The assessment periods in all consecutive typical KLS healthy controls included the non-verbal intelligence quotient (Raven Progressive Matrices), Trail Making Test, Stroop Color-Word Wechsler Memory verbal...
Question Experimentally inducing dyspnea in healthy volunteers is a powerful research tool. Even though this approach not considered to carry particular risks, occurs general context of stress. We hypothesized that experimental could be traumatic some individuals, with immediate or delayed adverse psychological reactions. Methods Forty participants (median age 38.7 interquartile range [29.7–49.1]; 20 women) were exposed, random order, inspiratory threshold loading (ITL; “excessive breathing...
Abstract Background Dyspnea conveys an upsetting or distressing experience of breathing awareness. It heavily weighs on chronic respiratory disease patients, particularly when it persists despite maximal treatment causative abnormalities. The physical, psychological and social impacts persistent dyspnea are ill-appreciated by others. This invisibility constitutes a barrier impedes access to care. study aimed better understand in patients with obstructive pulmonary (COPD) through quantitative...
More than a symptom, dyspnoea is an existential experience shaping the lives of those afflicted, particularly when its persistence despite maximal pathophysiological treatments makes it pervasive. It is, however, insufficiently appreciated by concerned people themselves, family members, healthcare professionals and public (dyspnoea invisibility), limiting access to appropriate care support.To provide better understanding experiences invisibility.Interpretative phenomenological analysis data...
In contrast with pain, dyspnoea is not visible to the general public, who lack corresponding experiential baggage. We tested hypothesis that generalised use of face masks fight severe acute respiratory syndrome coronavirus 2 dissemination could change this and sensitise people health.General population polling (1012-person panel demographically representative adult French population, quota sampling method; 517 (51%) female). 860 (85%) answered "no" "treated for a chronic disease"...
In healthy humans, inspiratory threshold loading deteriorates cognitive performances. This can result from motor-cognitive interference (activation of motor respiratory-related cortical networks vs. executive resources allocation), sensory-cognitive (dyspnea shift in attentional focus), or both. We hypothesized that would concomitantly induce dyspnea, activate networks, and deteriorate performance. reasoned a concomitant activation deterioration be compatible with interference, particularly...
Camptocormia (a flexion of the trunk that only appears when standing or walking) affects a minority patients with Parkinson's disease (PD). As it responds poorly to levodopa and is associated reduced midbrain pons volume, may result from non-dopaminergic, brainstem lesions. several sleep abnormalities in PD also non-dopaminergic lesions, we monitored 24 non-demented (n = 12) without camptocormia 12 controls. Nearly half (42%) had abnormal periodic leg movement indices (>15/h), versus 17% 8%...
Dyspnea is a frightening and debilitating experience. It attracts less attention than pain ('dyspnea invisibility'), possibly because of its non-universal nature. We tested the impact self-induced experimental dyspnea on medical residents.During teaching session following principles experiential learning, emergency medicine residents were taught about theoretically, observed in their teacher, personally experienced dyspnea. The corresponding psychophysiological reactions described. Immediate...
Chronic Obstructive Pulmonary Disease (COPD) is one of the top 10 causes death worldwide, representing a major public health problem. Researchers have been looking for new technologies and methods patient monitoring with intention an early identification acute exacerbation events. Many these works focusing in breathing rate variation, while achieving unsatisfactory sensitivity and/or specificity. This study aims to identify features that better describe respiratory pattern changes short-term...