A5075924830- Sleep and Wakefulness Research
- Sleep and related disorders
- EEG and Brain-Computer Interfaces
- Memory and Neural Mechanisms
- Restless Legs Syndrome Research
- Neural dynamics and brain function
- Psychoanalysis and Psychopathology Research
- Functional Brain Connectivity Studies
- Parkinson's Disease Mechanisms and Treatments
- Mind wandering and attention
- Neuroscience of respiration and sleep
- Circadian rhythm and melatonin
- Neurological disorders and treatments
- Dementia and Cognitive Impairment Research
- Cognitive Science and Mapping
- Genetic Neurodegenerative Diseases
- Neural and Behavioral Psychology Studies
- Eating Disorders and Behaviors
- Obstructive Sleep Apnea Research
- Neuroscience and Music Perception
- Neuroscience and Neuropharmacology Research
- Sleep and Work-Related Fatigue
- Action Observation and Synchronization
- Cognitive Abilities and Testing
- Educational Outcomes and Influences
Assistance Publique – Hôpitaux de Paris
2008-2024
Sorbonne Université
2010-2024
Institut du Cerveau
2010-2024
Inserm
2010-2024
Centre National de la Recherche Scientifique
2010-2024
Pitié-Salpêtrière Hospital
2009-2024
Sorbonne University Abu Dhabi
2024
Centre Hospitalier Universitaire de Lille
2024
Institut de Psychiatrie et Neurosciences de Paris
2023
Université Paris 1 Panthéon-Sorbonne
2022
Consolidation makes it possible for memories of our daily experiences to be stored in an enduring way. We propose that memory consolidation depends on the covert reactivation previously learned material both during sleep and wakefulness. Here we tested whether operation influences fundamental selectivity storage—of all events experience each day, which will retained forgotten? systematically manipulated value information by 60 young subjects; they 72 object-location associations while...
Early biomarkers are needed to identify individuals at high risk of preclinical Alzheimer's disease and better understand the pathophysiological processes progression. Preclinical EEG changes would be non-invasive cheap screening tools could also help predict future progression clinical disease. However, impact amyloid-β deposition neurodegeneration on needs elucidated. We included participants from INSIGHT-preAD cohort, which is an ongoing single-centre multimodal observational study that...
<h3>Background</h3> Sleep disorders including insomnia, movements during sleep, and daytime sleepiness are common but poorly studied in Huntington disease (HD). <h3>Objective</h3> To evaluate the HD sleep-wake phenotype (including abnormal motor activity sleep) patients with various stages length of CAG repeats. Because a mild hypocretin deficiency has been found brains some (hereinafter referred to as patients), we also tested for narcolepsy. <h3>Design Patients</h3> Twenty-five 2...
Sleep terrors and sleepwalking are described as arousals from slow wave sleep with no or poor mental recollection. To characterize the content retrospectively associated sleepwalking. University Hospital Controlled prospective cohort Forty-three patients referred for severe sleepwalking/sleep (age: 26 ± 7 y, 46% men, 5 only, 8 30 both), matched 25 healthy control subjects. Thirty-eight of 43 (88%) underwent an interview about frequency, time, behaviors, episodes terrors, whenever they...
<b>Objective:</b> To document unusual, nonviolent behaviors during REM sleep behavior disorder (RBD) and evaluate their frequency in Parkinson disease (PD). <b>Background:</b> Most previously described RBD mimic attacks, suggesting they proceed from archaic defense generators the brainstem. Feeding, drinking, sexual behaviors, urination, defecation have not been documented yet RBD. <b>Methods:</b> We collected 24 cases of idiopathic symptomatic (narcolepsy, dementia with Lewy bodies, PD),...
When sounds associated with learning are presented again during slow-wave sleep, targeted memory reactivation (TMR) can produce improvements in subsequent location recall. Here we used TMR to investigate consolidation an afternoon nap as a function of prior learning. Twenty healthy individuals (8 male, 19–23 y old). Participants learned associate each 50 common objects unique screen location. object appeared, its characteristic sound was played. After electroencephalography (EEG) electrodes...
Dreams take us to a different reality, hallucinatory world that feels as real any waking experience. These often-bizarre episodes are emblematic of human sleep but have yet be adequately explained. Retrospective dream reports subject distortion and forgetting, presenting fundamental challenge for neuroscientific studies dreaming. Here we show individuals who asleep in the midst lucid (aware fact they currently dreaming) can perceive questions from an experimenter provide answers using...
The influence of mood on choices is a well-established but poorly understood phenomenon. Here, we suggest three-fold neuro-computational account: (1) the integration positive and negative events over time induce fluctuations, (2) which are underpinned by variations in baseline activities critical brain valuation regions, (3) turn modulate relative weights assigned to key dimensions choice options. We validate this model healthy participants, using feedback quiz task (accepting vs. declining...
A single minute of sleep onset is sufficient to boost the probability insight by a factor three compared wake.
Sleep has long been considered as a state of behavioral disconnection from the environment, without reactivity to external stimuli. Here we questioned this 'sleep disconnection' dogma by directly investigating responsiveness in 49 napping participants (27 with narcolepsy and 22 healthy volunteers) engaged lexical decision task. Participants were instructed frown or smile depending on stimulus type. We found accurate responses, visible via contractions corrugator zygomatic muscles, most sleep...
Rapid eye movements and complex visual dreams are salient features of human rapid movement sleep. However, it remains to be elucidated whether the eyes scan dream images, despite studies that have retrospectively compared direction recall recorded after having awakened sleeper. We used model sleep behaviour disorder (when patients enact their by persistence muscle tone) determine directly move in same directions as head limbs. In 56 with 17 healthy matched controls, were monitored...
Multiple system atrophy is an atypical parkinsonism characterized by severe motor disabilities that are poorly levodopa responsive. Most patients develop rapid eye movement sleep behaviour disorder. Because absent during disorder in with Parkinson's disease, we studied the movements of multiple sleep. Forty-nine non-demented and 49 idiopathic disease were interviewed along their 98 bed partners using a structured questionnaire. They rated quality movements, vocal facial expressions as better...
Narcolepsy with cataplexy is a sleep disorder characterized by excessive daytime sleepiness, irresistible episodes, and sudden loss of muscle tone (cataplexy) mostly triggered emotions. disabling lifelong frequently arising during childhood. Pediatric narcolepsy often results in severe learning social impairment. Improving awareness about this condition increases early diagnosis may allow patients to rapidly access adequate treatments, including pharmacotherapy and/or non-medication-based...
Creative problem-solving is central in daily life, yet its underlying mechanisms remain elusive. Restructuring (i.e., reorganization of problem-related representations) considered one mechanism and may lead to an abstract representation facilitating the solving analogous problems. Here, we used network science methodology estimate participants' semantic memory networks (SemNets) before after attempting solve a riddle. was quantified as difference SemNets metrics between pre- post-solving...