A5020640175- Sleep and Wakefulness Research
- Sleep and related disorders
- Circadian rhythm and melatonin
- Obstructive Sleep Apnea Research
- Neuroscience and Neuropharmacology Research
- Regulation of Appetite and Obesity
- Neuroscience of respiration and sleep
- Restless Legs Syndrome Research
- Genetics and Neurodevelopmental Disorders
- Biochemical Analysis and Sensing Techniques
- EEG and Brain-Computer Interfaces
- Sleep and Work-Related Fatigue
- Parkinson's Disease Mechanisms and Treatments
- Memory and Neural Mechanisms
- Tracheal and airway disorders
- Plant Molecular Biology Research
- Neural dynamics and brain function
- Neuroinflammation and Neurodegeneration Mechanisms
- Cholinesterase and Neurodegenerative Diseases
- Genetic Mapping and Diversity in Plants and Animals
- Asthma and respiratory diseases
- Photoreceptor and optogenetics research
- Neurobiology and Insect Physiology Research
- Receptor Mechanisms and Signaling
- Zebrafish Biomedical Research Applications
University of Lausanne
2015-2024
University of Geneva
1997-2023
UCB Pharma (Belgium)
2022
Lundbeck (Italy)
2022
University Hospital of Lausanne
2007-2019
Hôpital Gui de Chauliac
1989-2017
Inserm
1990-2017
Institute of Social and Preventive Medicine
2016
Swiss Integrative Center for Human Health
2015
Institute for Integrative and Experimental Genomics
2012
Delta power, a measure of EEG activity in the 1–4 Hz range, slow-wave sleep (SWS) is quantitative and predictive relationship with prior wakefulness. Thus, loss evokes proportional increase delta excess decrease. Therefore, power thought to reflect SWS need its underlying homeostatically regulated recovery process. The neurophysiological substrate this process unknown forward genetics might help elucidate nature what depleted during wakefulness recovered SWS. We applied mathematical method...
Sleep is regulated by a homeostatic process that determines its need and circadian timing. By using sleep deprivation transcriptome profiling in inbred mouse strains, we show genetic background affects susceptibility to loss at the transcriptional level tissue-dependent manner. In brain, Homer1a expression best reflects response loss. Time-course gene analysis suggests 2,032 brain transcripts are under control. However, only 391 remain rhythmic when mice sleep-deprived four time points...
Narcolepsy is a sleep disorder characterized by excessive daytime sleepiness and attacks of muscle atonia triggered strong emotions (cataplexy). caused hypocretin (orexin) deficiency, paralleled dramatic loss in hypothalamic hypocretin-producing neurons. It believed that narcolepsy an autoimmune disorder, although definitive proof this, such as the presence autoantibodies, still lacking. We engineered transgenic mouse model to identify peptides enriched within neurons could serve potential...
Study Objective:Prior research has identified five common genetic variants associated with narcolepsy cataplexy in Caucasian patients. To replicate and/or extend these findings, we have tested HLA-DQB1, the previously 5 variants, and 10 other potential a large European sample of subjects.
Genetic variation in the expression and regulation of sleep was assessed six inbred mice strains (AK, C, B6, BR, D2, 129). The amount, distribution, fragmentation behavioral states wakefulness (W), slow-wave (SWS), paradoxical (PS), as well EEG delta power SWS, were determined compared among between baseline recovery from a 6-hour deprivation (SD) starting at lights-on. In baseline, most striking strain differences concerned onset duration main rest period, SWS fragmentation. time course...
The genetic variation in spontaneous rhythmic electroencephalographic (EEG) activity was assessed by the quantitative analysis of EEG six inbred mice strains. Mean spectral profiles (0–25 Hz) over 24 h were obtained for paradoxical sleep (PS), slow-wave (SWS), and wakefulness. A highly significant genotype-specific found theta peak frequency during both PS SWS, which strongly suggests presence a gene with major effect. strain distribution exploratory behavior differed from that sleep. In...
DBP (albumin D-site-binding protein), HLF (hepatic leukemia factor), and TEF (thyrotroph embryonic factor) are the three members of PAR bZip (proline acidic amino acid-rich basic leucine zipper) transcription factor family. All these transcriptional regulatory proteins accumulate with robust circadian rhythms in tissues high amplitudes clock gene expression, such as suprachiasmatic nucleus (SCN) liver. However, they expressed at nearly invariable levels most brain regions, which expression...
<b><i>Background:</i></b> Kleine-Levin syndrome (KLS) is a rare disorder of unknown etiology. Pathophysiologic hypotheses include hypothalamic dysfunction and abnormalities in the central serotonin dopamine metabolism. Several clinical symptoms also suggest an underlying autoimmune process. <b><i>Objective:</i></b> To systematically investigate patients with KLS reference to available hypotheses. <b><i>Methods:</i></b> The authors collected clinical, polysomnographic, CSF, CT, MRI records...
Summary The aim of this study was to describe the clinical and PSG characteristics narcolepsy with cataplexy their genetic predisposition by using retrospective patient database European Narcolepsy Network ( EU ‐ NN ). We have analysed data 1099 patients diagnosed according International Classification Sleep Disorders‐2. Demographic characteristics, polysomnography multiple sleep latency test data, hypocretin‐1 levels, genome‐wide genotypes were available. found a significantly lower age at...
Although sleep is defined as a behavioral state, at the cortical level has local and use-dependent features suggesting that it property of neuronal assemblies requiring in function activation experienced during prior wakefulness. Here we show mature cultured neurons display default state characterized by synchronized burst-pause firing activity reminiscent sleep. This sleep-like can be changed to transient tonic wakefulness when cultures are stimulated with mixture waking neurotransmitters...
Objective Periodic limb movements during sleep (PLMS) are phenomena characterized by periodic episodes of repetitive stereotyped movements. The aim this study was to describe the prevalence and determinants PLMS in a middle older aged general population. Methods Data from 2,162 subjects (51.2% women, mean age = 58.4 ± 11.1 years) participating population‐based (HypnoLaus, Lausanne, Switzerland) were collected. Assessments included laboratory tests, sociodemographic data, personal treatment...
Objective. Although sleep is a biomarker for general health and pathological conditions, its changes across age gender are poorly understood.Methods. Subjective evaluation of was assessed by questionnaires in 5,064 subjects, 2,966 were considered without disorders. Objective performed polysomnography 2,160 1,147 Only subjects disorders included (aged 40–80 years).Results. Aging strongly associated with morning preference. Older especially women, complained less about sleepiness, sleepiness...
To assess the association between sleep structure and cognitive impairment in general population.Data stemmed from 580 participants aged >65 years of population-based CoLaus/PsyCoLaus study (Lausanne, Switzerland) who underwent complete evaluation (HypnoLaus). Evaluations included demographic characteristics, personal treatment history, complaints habits (using validated questionnaires), a polysomnography at home. Cognitive function was evaluated using comprehensive neuropsychological test...
Narcolepsy with cataplexy is a sleep disorder caused by deficiency in the hypothalamic neuropeptide hypocretin/orexin (HCRT), unanimously believed to result from autoimmune destruction of hypocretin-producing neurons. HCRT can also occur secondary forms narcolepsy and be only temporary, suggesting it without irreversible neuronal loss. The recent discovery that patients show loss (corticotropin-releasing hormone) CRH-producing neurons suggests other mechanisms than cell-specific attack, are...
Abstract Hypocretin/orexin deficiency appears to be a consistent feature of narcolepsy with putative autoimmune mechanism involved. We treated four hypocretin/orexin‐deficient patients intravenous immunoglobulins and assessed the efficacy by repeated polysomnographies questionnaires. Three received treatment within few months after acute onset narcolepsy. A clear improvement in frequency severity cataplexy was obtained benefic effect up 7 without any anticataplectics drugs at follow‐up. Our...