A5016480998- Mitochondrial Function and Pathology
- Adipose Tissue and Metabolism
- Genetics, Aging, and Longevity in Model Organisms
- Metabolism and Genetic Disorders
- Diet and metabolism studies
- Sirtuins and Resveratrol in Medicine
- ATP Synthase and ATPases Research
- Circadian rhythm and melatonin
- Metabolomics and Mass Spectrometry Studies
- RNA modifications and cancer
- Autophagy in Disease and Therapy
- Immune cells in cancer
- Calcium signaling and nucleotide metabolism
- Peroxisome Proliferator-Activated Receptors
- Biochemical Acid Research Studies
- Muscle metabolism and nutrition
- Dietary Effects on Health
- PARP inhibition in cancer therapy
- Genetic Neurodegenerative Diseases
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- Tryptophan and brain disorders
- Pancreatic function and diabetes
- Cancer, Hypoxia, and Metabolism
- RNA and protein synthesis mechanisms
University of Amsterdam
2016-2025
Amsterdam University Medical Centers
2018-2025
Emma Kinderziekenhuis
2018-2024
Amsterdam UMC Location University of Amsterdam
2012-2023
École Polytechnique Fédérale de Lausanne
2010-2023
Netherlands Metabolomics Centre
2023
Royal Netherlands Academy of Arts and Sciences
2023
Pennsylvania State University
2016
Goethe University Frankfurt
2014
University Hospital Frankfurt
2014
Aging is characterized by a general decline in cellular function, which ultimately will affect whole body homeostasis. Although DNA damage and oxidative stress all contribute to aging, metabolic dysfunction common hallmark of aging at least invertebrates. Since comprehensive overview changes otherwise healthy mammals lacking, we here compared parameters young 2 year old mice. We systemically integrated vivo phenotyping with gene expression, biochemical analysis metabolomics, thereby...
In recent years, tetracyclines, such as doxycycline, have become broadly used to control gene expression by virtue of the Tet-on/Tet-off systems. However, wide range direct effects tetracycline use has not been fully appreciated. We show here that these antibiotics induce a mitonuclear protein imbalance through their on mitochondrial translation, an effect likely reflects evolutionary relationship between mitochondria and proteobacteria. Even at low concentrations, tetracyclines proteotoxic...
Growth of numerous cancer types is believed to be driven by a subpopulation poorly differentiated cells, often referred as stem cells (CSCs), that have the capacity for self-renewal, tumor initiation, and generation nontumorigenic progeny. Despite their potentially key role in establishment maintenance, energy requirements these mechanisms regulate production are unknown. Here, we show oncofetal insulin-like growth factor 2 mRNA-binding protein (IMP2, IGF2BP2) regulates oxidative...
Cellular metabolism was recently shown to regulate endothelial cell phenotype profoundly. Whether the atheroprotective biomechanical stimulus elicited by laminar shear stress modulates is not known.Here, we show that flow exposure reduced glucose uptake and mitochondrial content in endothelium. Shear stress-mediated reduction of reversed silencing flow-sensitive transcription factor Krüppel-like 2 (KLF2). Endothelial-specific deletion KLF2 mice induced cells perfused hearts. overexpression...
Metformin is the first-line therapy for treating type 2 diabetes and a promising anti-aging drug. We set out to address fundamental question of how gut microbes nutrition, key regulators host physiology, affect effects metformin. Combining two tractable genetic models, bacterium E. coli nematode C. elegans, we developed high-throughput four-way screen define underlying host-microbe-drug-nutrient interactions. show that integrate cues from metformin diet through phosphotransferase signaling...
Metabolic reprogramming has emerged as a crucial regulator of immune cell activation, but how systemic metabolism influences and function remains to be investigated. To investigate the effect dyslipidemia on metabolism, we performed in-depth transcriptional, metabolic, functional characterization macrophages isolated from hypercholesterolemic mice. Systemic metabolic changes in such mice alter cellular macrophage attenuate inflammatory responses. In addition diminished maximal mitochondrial...
Abstract During sprouting angiogenesis, an individual endothelial tip cell grows out from a pre-existing vascular network and guides following proliferating stalk cells to form new vessel. Metabolic pathways such as glycolysis mitochondrial respiration the major sources of adenosine 5′-triphosphate (ATP) for energy production are differentially activated in these types (ECs) during angiogenesis. Therefore, we studied metabolism angiogenesis more detail non-tip human umbilical vein ECs. Small...