A5088404150- Sirtuins and Resveratrol in Medicine
- Liver Disease Diagnosis and Treatment
- Adipose Tissue and Metabolism
- Muscle Physiology and Disorders
- Nutrition and Health in Aging
- Autophagy in Disease and Therapy
- Pancreatic function and diabetes
- Cancer Immunotherapy and Biomarkers
- Metabolism, Diabetes, and Cancer
- Immune Cell Function and Interaction
- 3D Printing in Biomedical Research
- Diet, Metabolism, and Disease
- Genetics, Aging, and Longevity in Model Organisms
- Cancer, Hypoxia, and Metabolism
- Immune cells in cancer
- Mitochondrial Function and Pathology
- Cancer-related gene regulation
- Endoplasmic Reticulum Stress and Disease
- GDF15 and Related Biomarkers
- Diet and metabolism studies
- Nuclear Receptors and Signaling
- Additive Manufacturing and 3D Printing Technologies
- PARP inhibition in cancer therapy
- Gut microbiota and health
- Estrogen and related hormone effects
Gwangju Institute of Science and Technology
2023-2025
École Polytechnique Fédérale de Lausanne
2013-2025
Sungkyunkwan University
2011-2024
Sookmyung Women's University
2024
Wonkwang University
2021-2023
Samsung Medical Center
2020-2022
Gachon University
2022
Salk Institute for Biological Studies
2022
Kangbuk Samsung Hospital
2022
Ewha Womans University Medical Center
2022
Adult stem cells (SCs) are essential for tissue maintenance and regeneration yet susceptible to senescence during aging. We demonstrate the importance of amount oxidized form cellular nicotinamide adenine dinucleotide (NAD(+)) its effect on mitochondrial activity as a pivotal switch modulate muscle SC (MuSC) senescence. Treatment with NAD(+) precursor riboside (NR) induced unfolded protein response synthesis prohibitin proteins, this rejuvenated MuSCs in aged mice. NR also prevented MuSC mdx...
In recent years, tetracyclines, such as doxycycline, have become broadly used to control gene expression by virtue of the Tet-on/Tet-off systems. However, wide range direct effects tetracycline use has not been fully appreciated. We show here that these antibiotics induce a mitonuclear protein imbalance through their on mitochondrial translation, an effect likely reflects evolutionary relationship between mitochondria and proteobacteria. Even at low concentrations, tetracyclines proteotoxic...
With no approved pharmacological treatment, nonalcoholic fatty liver disease (NAFLD) is now the most common cause of chronic in Western countries and its worldwide prevalence continues to increase along with growing obesity epidemic. Here, we show that a high‐fat high‐sucrose (HFHS) diet, eliciting hepatosteatosis resembling human liver, lowers hepatic nicotinamide adenine dinucleotide (NAD + ) levels driving reductions mitochondrial content, function, adenosine triphosphate (ATP) levels,...
Reduced mitochondrial electron transport chain activity promotes longevity and improves energy homeostasis via cell-autonomous –non-autonomous factors in multiple model systems. This mitohormetic effect is thought to involve the unfolded protein response (UPRmt), an adaptive stress-response pathway activated by proteotoxic stress. Using mice with skeletal muscle–specific deficiency of Crif1 (muscle-specific knockout [MKO]), integral large mitoribosomal subunit (39S), we identified growth...
Significance Lysine succinylation is a recently discovered protein posttranslational modification and SIRT5 an efficient desuccinylase. Although many mammalian proteins have been found to be regulated by lysine SIRT5, the physiological significance of remains unknown. Here we report that predominantly accumulates in heart when Sirt5 deleted. -deficient mice exhibit defective fatty acid metabolism, decreased ATP production, hypertrophic cardiomyopathy. Our data suggest regulating metabolism...
NAD + treatment can reverse the functional decline in degenerating muscles.
Orphan nuclear receptor small heterodimer partner (SHP) plays a key role in transcriptional repression of gluconeogenic enzyme gene expression. Here, we show that SHP inhibited protein kinase A-mediated activity cAMP-response element-binding (CREB), major regulator glucose metabolism, to modulate hepatic Deletion analysis phosphoenolpyruvate carboxykinase (PEPCK) promoter demonstrated forskolin-mediated induction PEPCK transcription via inhibition CREB activity. In vivo imaging...
Oxidative functions of adipose tissue macrophages control the polarization M1-like and M2-like phenotypes, but whether reduced macrophage oxidative function causes systemic insulin resistance in vivo is not clear. Here, we show that mice with mitochondrial phosphorylation (OxPhos) due to myeloid-specific deletion CR6-interacting factor 1 (Crif1), an essential mitoribosomal involved biogenesis OxPhos subunits, have inflammation. Macrophage GDF15 expression impaired function, induced upon...
Recently, several studies have demonstrated that tetracyclines, the antibiotics most intensively used in livestock and are also widely applied biomedical research, interrupt mitochondrial proteostasis physiology animals ranging from round worms, fruit flies, mice to human cell lines. Importantly, plant chloroplasts, like their mitochondria, under certain conditions vulnerable these other leached into our environment. Together endosymbiotic organelles not only essential for cellular...
To date, no pharmacological therapy has been approved for non-alcoholic fatty liver disease (NAFLD). The aim of the present study was to evaluate therapeutic potential poly ADP-ribose polymerase (PARP) inhibitors in mouse models NAFLD.As ADP-ribosylation (PARylation) proteins by PARPs consumes nicotinamide adenine dinucleotide (NAD+), we hypothesized that overactivation drives NAD+ depletion NAFLD. Therefore, assessed effectiveness PARP inhibition replenish and activate NAD+-dependent...