A5036489378- Immune cells in cancer
- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- Cancer, Hypoxia, and Metabolism
- Melanoma and MAPK Pathways
- CAR-T cell therapy research
- T-cell and B-cell Immunology
- Cytokine Signaling Pathways and Interactions
- Epigenetics and DNA Methylation
- Cancer Mechanisms and Therapy
- Immunotherapy and Immune Responses
- interferon and immune responses
- Autophagy in Disease and Therapy
- Phagocytosis and Immune Regulation
- Ubiquitin and proteasome pathways
- Adipose Tissue and Metabolism
- Cancer, Lipids, and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Cancer Research and Treatments
- Endoplasmic Reticulum Stress and Disease
- Peptidase Inhibition and Analysis
- Histone Deacetylase Inhibitors Research
- Retinoids in leukemia and cellular processes
- Macrophage Migration Inhibitory Factor
- vaccines and immunoinformatics approaches
University of Lausanne
2016-2025
Ludwig Cancer Research
2016-2025
University Hospital of Lausanne
2024
Wuhan University
2022
Renmin Hospital of Wuhan University
2022
Xiamen University
2022
VIB-KU Leuven Center for Cancer Biology
2019
University of Minho
2019
University of Zurich
2019
Yale University
2012-2019
<h3>Background</h3> Several mechanisms are present in the tumor microenvironment (TME) to impair cytotoxic T cell responses potentially able control growth. Among these, accumulation of adenosine (Ado) contributes progression and represents a promising immunotherapeutic target. Ado has been shown effector function, but role employed by Ado/Ado receptors (AdoRs) modulating human peripheral tumor-infiltrating lymphocyte (TIL) function still puzzling. <h3>Methods</h3> CD8<sup>+</sup> cytokine...
Glycolysis, including both lactate fermentation and pyruvate oxidation, orchestrates CD8+ T cell differentiation. However, how mitochondrial metabolism uptake controlled by the carrier (MPC) impact function fate remains elusive. We found that genetic deletion of MPC drives differentiation toward a memory phenotype. Metabolic flexibility induced inhibition facilitated acetyl-coenzyme-A production glutamine fatty acid oxidation results in enhanced histone acetylation chromatin accessibility on...