A5080041935- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Lung Cancer Treatments and Mutations
- Cancer Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Virus-based gene therapy research
- Viral Infectious Diseases and Gene Expression in Insects
- Phagocytosis and Immune Regulation
- T-cell and B-cell Immunology
- Pancreatic function and diabetes
- Cancer, Hypoxia, and Metabolism
- Cancer Research and Treatments
Temple University
2024
Ludwig Cancer Research
2022-2023
University of Lausanne
2020-2023
Centre Hospitalier Universitaire de Limoges
2018
Glycolysis, including both lactate fermentation and pyruvate oxidation, orchestrates CD8+ T cell differentiation. However, how mitochondrial metabolism uptake controlled by the carrier (MPC) impact function fate remains elusive. We found that genetic deletion of MPC drives differentiation toward a memory phenotype. Metabolic flexibility induced inhibition facilitated acetyl-coenzyme-A production glutamine fatty acid oxidation results in enhanced histone acetylation chromatin accessibility on...
Activated T cells undergo a metabolic shift to aerobic glycolysis support the energetic demands of proliferation, differentiation, and cytolytic function. Transmembrane glucose flux is facilitated by transporters (GLUT) that play vital role in cell reprogramming anti-tumour GLUT isoforms are regulated at level expression subcellular distribution. GLUTs also display preferential selectivity for carbohydrate macronutrients including glucose, galactose, fructose. GLUT5, which selectively...
Background: Immune checkpoint blockade represents a major breakthrough in cancer therapy with recent approvals of PD-1 or PD-L1 antagonist France for range indications. To generate high evidenced-based knowledge and to prevent off-label use, the French National Cancer Institute (INCa) launched AcSé Immuno-therapy Program: two exploratory phase II trials, allow nationwide safe controlled access nivolumab pembrolizumab outside their current marketing selected rare indications where literature...
<h3>Background</h3> Adoptive cell transfer (ACT) therapies are successfully used in the clinic; however, a large fraction of patients remains unresponsive. The limited efficacy this therapy is due, part, to terminally differentiated state transferred T cells, which limits their proliferation and long-lasting antitumor response. Memory CD8+ cells display specific phenotypic functional characteristics endowing them with ability provide more robust immune response than counterparts. development...