Bart Ghesquière
A5028713739- Cancer, Lipids, and Metabolism
- Ferroptosis and cancer prognosis
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Acute Myeloid Leukemia Research
- CAR-T cell therapy research
- Glycosylation and Glycoproteins Research
- Metabolomics and Mass Spectrometry Studies
- Immune cells in cancer
- Mitochondrial Function and Pathology
- Advanced Proteomics Techniques and Applications
- Prostate Cancer Treatment and Research
- Cancer Mechanisms and Therapy
- Angiogenesis and VEGF in Cancer
- Histone Deacetylase Inhibitors Research
- Pancreatic function and diabetes
- Immune Cell Function and Interaction
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Metabolism and Genetic Disorders
- COVID-19 Clinical Research Studies
- Adenosine and Purinergic Signaling
- Metabolism, Diabetes, and Cancer
- Mass Spectrometry Techniques and Applications
- Ubiquitin and proteasome pathways
VIB-KU Leuven Center for Cancer Biology
2016-2025
KU Leuven
2016-2025
Vlaams Instituut voor Biotechnologie
2004-2024
Sixth Affiliated Hospital of Sun Yat-sen University
2023
Sun Yat-sen University
2023
IONICS Mass Spectrometry (Canada)
2023
The Open University
2022
Cancer Research UK Scotland Institute
2022
Ghent University
2007-2021
VIB-UGent Center for Inflammation Research
2021
Abstract Profound metabolic changes are characteristic of macrophages during classical activation and have been implicated in this phenotype. Here we demonstrate that nitric oxide (NO) produced by murine is responsible for TCA cycle alterations citrate accumulation associated with polarization. 13 C tracing mitochondrial respiration experiments map NO-mediated suppression metabolism to aconitase (ACO2). Moreover, find inflammatory reroute pyruvate away from dehydrogenase (PDH) an...
Glutamine-synthetase (GS), the glutamine-synthesizing enzyme from glutamate, controls important events, including release of inflammatory mediators, mammalian target rapamycin (mTOR) activation, and autophagy. However, its role in macrophages remains elusive. We report that pharmacologic inhibition GS skews M2-polarized toward M1-like phenotype, characterized by reduced intracellular glutamine increased succinate with enhanced glucose flux through glycolysis, which could be partly related to...
Highlights•A metabolic shift defines NSPC quiescence versus proliferation•Quiescent NSPCs require high levels of FAO•Changing a single metabolite is sufficient to induce proliferationSummaryHippocampal neurogenesis important for certain forms cognition, and failing has been implicated in neuropsychiatric diseases. The neurogenic capacity hippocampal neural stem/progenitor cells (NSPCs) depends on balance between quiescent proliferative states. Here, we show that the rate fatty acid oxidation...