A5074606507- Coronary Interventions and Diagnostics
- Cardiac Valve Diseases and Treatments
- COVID-19 Clinical Research Studies
- Acute Myocardial Infarction Research
- SARS-CoV-2 and COVID-19 Research
- Cardiac Imaging and Diagnostics
- Mesenchymal stem cell research
- Cardiac Arrest and Resuscitation
- Venous Thromboembolism Diagnosis and Management
- Cardiac Ischemia and Reperfusion
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac pacing and defibrillation studies
- Transplantation: Methods and Outcomes
- Cardiac Arrhythmias and Treatments
- Bone fractures and treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac Fibrosis and Remodeling
- Cardiac electrophysiology and arrhythmias
- Long-Term Effects of COVID-19
- Cardiovascular Function and Risk Factors
- Infective Endocarditis Diagnosis and Management
- Cancer Immunotherapy and Biomarkers
- Cardiac Structural Anomalies and Repair
- Endometrial and Cervical Cancer Treatments
- Acute Ischemic Stroke Management
KU Leuven
2016-2025
Statistics Belgium
2010-2025
Hasselt University
2013-2022
Universitair Ziekenhuis Leuven
2014-2020
Deutsches Herzzentrum München
2017
St. Antonius Ziekenhuis
2017
Technical University of Munich
2017
Glenfield Hospital
2017
Catholic University of America
2011
Over the past decades, life expectancy of individuals with congenital heart disease (CHD) has increased significantly. However, precise estimates for survival to adulthood are scarce patients CHD. We investigated proportion CHD born between 1990 and 1992 who survived into adulthood. also compared their that in earlier eras evaluated as a function type defect.We reviewed program administrative clinical database at University Hospitals Leuven (Leuven, Belgium) analyzed records 7497 from 1970...
Approximately 70% of persons who have an out-of-hospital cardiac arrest underlying acute myocardial infarction or pulmonary embolism. Therefore, thrombolysis during cardiopulmonary resuscitation may improve survival.
<h3>Objective</h3> Achalasia is a chronic motility disorder of the oesophagus for which laparoscopic Heller myotomy (LHM) and endoscopic pneumodilation (PD) are most commonly used treatments. However, prospective data comparing their long-term efficacy lacking. <h3>Design</h3> 201 newly diagnosed patients with achalasia were randomly assigned to PD (n=96) or LHM (n=105). Before randomisation, symptoms assessed using Eckardt score, functional test performed quality life was assessed. The...
Stent thrombosis (ST) is a serious complication following coronary stenting. Intravascular optical coherence tomography (OCT) may provide insights into mechanistic processes leading to ST. We performed prospective, multicenter study evaluate OCT findings in patients with ST.Consecutive presenting ST were prospectively enrolled registry by using centralized telephone registration system. After angiographic confirmation of ST, imaging the culprit vessel was frequency domain OCT. Clinical data...
Apical rocking (ApRock) and septal flash (SF) are often observed phenomena in asynchronously contracting ventricles. We investigated the relationship of visually assessed ApRock SF, reverse remodelling, long-term survival cardiac resynchronization therapy (CRT) candidates.A total 1060 patients eligible for CRT underwent echocardiographic examinations before 12 ± 6 months after device implantation. Three blinded physicians were asked to assess presence SF implantation also their correction by...
During the first 6-12 h of intensive care unit (ICU) stay, post-cardiac arrest (CA) patients treated with a mean arterial pressure (MAP) 65 mmHg target experience drop cerebral oxygenation that may cause additional damage. Therefore, we investigated whether an early goal directed haemodynamic optimization strategy (EGDHO) (MAP 85-100 mmHg, SVO2 65-75%) is safe and could improve oxygenation, reduce anoxic brain damage, outcome when compared MAP strategy.A total 112 out-of-hospital CA were...
We evaluated the histamine 1 receptor antagonist ebastine as a potential treatment for patients with non-constipated irritable bowel syndrome (IBS) in randomised, placebo-controlled phase 2 study.
Previous studies have suggested that intravenous administration of adenosine improves myocardial reperfusion and reduces infarct size in ST-elevation infarction (STEMI) patients. Intracoronary has shown conflicting results. In a prospective, single-centre, double-blind, placebo-controlled clinical study, we assessed whether selective intracoronary distal to the occlusion site immediately before initial balloon inflation results salvage decreased microvascular obstruction (MVO) as with...
Abstract Background Despite improvements in medical therapy, the majority of patients with Crohn's disease still require surgery. The aim this study was to report safety, and clinical surgical recurrence rates, including predictors recurrence, after ileocaecal resection for disease. Methods This a cohort analysis consecutive undergoing first between 1998 2013 at one two specialist centres. Anastomotic leak rate associated risk factors were assessed. Kaplan–Meier estimates used describe...
AimsTo investigate whether intracoronary transfer of bone marrow progenitor cells (BMPCs) early after reperfusion an acute myocardial infarction improves regional function in a randomized double-blind, placebo-controlled strain rate imaging study.
Little is known about the respective healing responses and clinical efficacy safety of drug-eluting balloons (DEB) second generation stents (DES) when used to treat in-stent restenosis (ISR). In this study, we set out compare prospectively characteristics, as assessed by optical coherence tomography (OCT), DEB versus DES after treatment ISR in bare metal (BMS).Fifty patients with BMS were randomised a paclitaxel-eluting balloon vs. an everolimus-eluting stent (EES). The primary endpoint was...
Rationale: Allogeneic cardiac stem cells (AlloCSC-01) have shown protective, immunoregulatory, and regenerative properties with a robust safety profile in large animal models of heart disease. Objective: To investigate the feasibility early administration AlloCSC-01 patients ST-segment–elevation myocardial infarction. Methods Results: CAREMI (Safety Efficacy Intracoronary Infusion Human Cardiac Stem Cells Patients With STEMI Left Ventricular Dysfunction) was phase I/II multicenter,...
Rationale: Azithromycin prevents acute exacerbations of chronic obstructive pulmonary disease (AECOPDs); however, its value in the treatment an AECOPD requiring hospitalization remains to be defined.Objectives: We investigated whether a 3-month intervention with low-dose azithromycin could decrease failure (TF) when initiated at hospital admission and added standard care.Methods: In investigator-initiated, multicenter, randomized, double-blind, placebo-controlled trial, patients who had been...
Bone marrow-derived mononuclear cell (BM-MNC) therapy may improve myocardial recovery in patients following acute infarction (AMI), though existing trial results are inconsistent.Originally an open-label, multicentre Phase III trial, BAMI was designed to demonstrate the safety and efficacy of intracoronary infusion BM-MNCs reducing time all-cause mortality with reduced left ventricular ejection fraction (LVEF, ≤45%) after primary angioplasty (PPCI) for ST-elevation AMI. Unexpectedly low...
Background Several randomised clinical trials have studied convalescent plasma for coronavirus disease 2019 (COVID-19) using different protocols, with severe acute respiratory syndrome 2 (SARS-CoV-2) neutralising antibody titres, at time-points and severities of illness. Methods In the prospective multicentre DAWn-plasma trial, adult patients hospitalised COVID-19 were to 4 units open-label combined standard care (intervention group) or alone (control group). Plasma from donors titres (50%...
A phase II study (PRIMMO) of patients with pretreated persistent/recurrent/metastatic cervical or endometrial cancer is presented. Patients received an immunomodulatory five-drug cocktail (IDC) consisting low-dose cyclophosphamide, aspirin, lansoprazole, vitamin D, and curcumin starting 2 weeks before radioimmunotherapy. Pembrolizumab was administered three-weekly from day 15 onwards; one the tumor lesions irradiated (8Gyx3) on days 15, 17, 19. The primary endpoint objective response rate...
To investigate maternal characteristics, underlying factors and perinatal outcome in pregnancies with persistent uninterpretable prenatal cfDNA screening a general obstetric population (GOP). This study included pregnant individuals results from December 2020 to 2022. Prenatal were classified as due low quality score (LQS) or fetal fraction (LFF). Maternal autoimmune third performed later pregnancy. Data on characteristics analyzed. Among 123 failed screening, 68% LFF 32% LQS. Obesity...
Over the past 13 years bone marrow‐derived mononuclear cells ( BM‐MNCs ) have been widely investigated for clinical efficacy in patients following acute myocardial infarction AMI ). These early phase II trials used various surrogate markers to judge and, although promising, results inconsistent. The III BAMI trial has therefore designed demonstrate that intracoronary infusion of is safe and will significantly reduce time first occurrence all‐cause death with reduced left ventricular ejection...