A5064338053- Coronary Interventions and Diagnostics
- Cerebrovascular and Carotid Artery Diseases
- Optical Coherence Tomography Applications
- Cardiac Imaging and Diagnostics
- Peripheral Artery Disease Management
- Aortic aneurysm repair treatments
- Intracranial Aneurysms: Treatment and Complications
- Photoacoustic and Ultrasonic Imaging
- Cardiac Valve Diseases and Treatments
- Atherosclerosis and Cardiovascular Diseases
- Retinal Imaging and Analysis
- Integrated Circuits and Semiconductor Failure Analysis
- Antiplatelet Therapy and Cardiovascular Diseases
- Retinal and Optic Conditions
- Renal and Vascular Pathologies
- Protease and Inhibitor Mechanisms
- Vascular Malformations Diagnosis and Treatment
- Angiogenesis and VEGF in Cancer
- Acute Ischemic Stroke Management
- Acute Myocardial Infarction Research
- Cardiovascular Health and Disease Prevention
- Cardiovascular Disease and Adiposity
- Cardiac and Coronary Surgery Techniques
- Ultrasound Imaging and Elastography
- Digital Imaging in Medicine
University of Massachusetts Chan Medical School
2018-2024
Sudbury Foundation
2023
Harvard University
2014-2021
UMass Memorial Health Care
2021
Massachusetts General Hospital
2012-2021
KU Leuven
2011-2017
Brigham and Women's Hospital
2016
Nuovo Ospedale San Giovanni di Dio
2015-2016
Beth Israel Deaconess Medical Center
2015
CVPath Institute
2013
The purpose of this document is to make the output International Working Group for Intravascular Optical Coherence Tomography (IWG-IVOCT) Standardization and Validation available medical scientific communities, through a peer-reviewed publication, in interest improving diagnosis treatment patients with atherosclerosis, including coronary artery disease. optical coherence tomography (IVOCT) catheter-based modality that acquires images at resolution ∼10 μm, enabling visualization blood vessel...
Intravascular optical coherence tomography (IVOCT) is rapidly becoming the method of choice for in vivo investigation coronary artery disease. While IVOCT visualizes atherosclerotic plaques with a resolution <20µm, image analysis terms tissue composition currently performed by time-consuming manual procedure based on qualitative interpretation features. We illustrate an algorithm automated and systematic characterization tissue. The proposed consists supervised classification pixels...
To validate optical coherence tomography (OCT) imaging for assessment of vascular healing in a preclinical animal model and human autopsy cases to translate the findings after drug-eluting stent implantation clinical practice.Drug-eluting bare metal stents were imaged 28 42 days atherosclerotic rabbits using OCT simultaneously evaluated by histology. After coregistration with histology, gray-scale signal intensity (GSI) was measured identified mature or immature neointimal tissue. Autopsy...
Little is known about the respective healing responses and clinical efficacy safety of drug-eluting balloons (DEB) second generation stents (DES) when used to treat in-stent restenosis (ISR). In this study, we set out compare prospectively characteristics, as assessed by optical coherence tomography (OCT), DEB versus DES after treatment ISR in bare metal (BMS).Fifty patients with BMS were randomised a paclitaxel-eluting balloon vs. an everolimus-eluting stent (EES). The primary endpoint was...
Optical coherence tomography (OCT) is an optical diagnostic modality that can acquire cross-sectional images of the microscopic structure esophagus, including Barrett's esophagus (BE) and associated dysplasia.We developed a swallowable tethered capsule OCT endomicroscopy (TCE) device acquires high-resolution entire gastrointestinal (GI) tract luminal organs.This has potential to become screening method identifies patients with abnormal should be further referred for upper...
Abstract Intravascular imaging has emerged as a valuable tool for the treatment of coronary and peripheral artery disease; however, no solution is available safe reliable use in tortuous vascular anatomy brain. Endovascular stroke delivered under image guidance with insufficient resolution to adequately assess underlying arterial pathology therapeutic devices. High-resolution imaging, enabling surgeons visualize cerebral arteries' microstructure micron-level features neurovascular devices,...
Fibrin deposition and absent endothelium characterize unhealed stents that are at heightened risk of stent thrombosis. Optical coherence tomography (OCT) is increasingly used for assessing tissue coverage as a measure healed stents, but cannot precisely identify whether overlying represents physiological neointima. Here we assessed compared fibrin persistence on bare metal (BMS) drug-eluting (DES) using near-infrared fluorescence (NIRF) molecular imaging in vivo, combination with...
Endovascular interventions are increasingly becoming the preferred approach for treating strokes and cerebral artery diseases. These procedures rely on sophisticated angiographical imaging guidance, which encounters challenges because of limited contrast spatial resolution. Achieving a more precise visualization underlying arterial pathology neurovascular implants is crucial accurate procedural decision-making. In human study involving 32 patients, we introduced clinical application...
While optical coherence tomography (OCT) has been shown to be capable of imaging coronary plaque microstructure, additional chemical/molecular information may needed in order determine which lesions are at risk causing an acute event.In this study, we used a recently developed system and double-clad fiber (DCF) catheter simultaneously acquiring both OCT red excited nearinfrared autofluorescence (NIRAF) images (excitation: 633 nm, emission: 680nm 900nm).We found that NIRAF is elevated contain...
AimsThe aim of this study was to investigate the reproducibility intravascular optical coherence tomography (IVOCT) assessments, including a comparison ultrasound (IVUS). Intra-observer and inter-observer variabilities IVOCT have been previously described, whereas inter-institute reliability in multiple laboratories has never systematically studied.
BackgroundVessel wall injury after drug-eluting stent (DES) implantation can be characterized in detail by optical coherence tomography (OCT). Little is known about the healing course of these phenomena.
Intravascular optical coherence tomography (IV-OCT) is an imaging modality that can be used for the assessment of intracoronary stents. Recent publications pointed to fact 3D visualizations have potential advantages compared conventional 2D representations. However, still requires a time consuming manual procedure not suitable on-line application during coronary interventions. We propose algorithm rapid and fully automatic visualization IV-OCT pullbacks. images are first processed...
Intravascular optical coherence tomography (IV-OCT) is a catheter-based high-resolution imaging technique able to visualize the inner wall of coronary arteries and implanted devices in vivo with an axial resolution below 20 μm. IV-OCT being used several clinical trials aiming quantify vessel response stent implantation over time. However, analysis currently performed manually corresponding images taken at different time points are matched through very labor-intensive subjective procedure. We...
AimsThis study aimed to validate automatic intravascular optical coherence tomography (IVOCT) analysis for the evaluation of neointimal coverage in response stent implantation.
To compare tissue coverage in coronary lesions stented with durable fluoropolymer-coated everolimus-eluting stents (EES) vs. biodegradable polymer-coated biolimus A9-eluting (BES).Sixty-four patients (64 lesions) de novo artery were randomised to percutaneous treatment XIENCE EES (Abbott Vascular, Santa Clara, CA, USA) BioMatrix BES (Biosensors, Morges, Switzerland). The primary endpoint was the percentage of uncovered struts, as assessed OCT, at nine months. average struts significantly...
We aimed to compare healing responses with optical coherence tomography, and clinical angiographic outcome after treatment of coronary bifurcation lesions a dedicated stent versus conventional culotte technique.Forty patients true complex were randomly assigned the Axxess™ in proximal main vessel (MV) additional BioMatrix™ stents branches (Biosensors Europe SA, Morges, Switzerland), technique using XIENCE™ (Abbott Vascular, Santa Clara, CA, USA). The primary endpoint percentage uncovered...