A5059646387- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Cerebrovascular and Carotid Artery Diseases
- Coronary Interventions and Diagnostics
- Cardiovascular Disease and Adiposity
- Cardiovascular Health and Disease Prevention
- Atrial Fibrillation Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- Ultrasound Imaging and Elastography
- Cardiac Arrhythmias and Treatments
- Cardiac Valve Diseases and Treatments
- Acute Ischemic Stroke Management
- Intracranial Aneurysms: Treatment and Complications
- Photoacoustic and Ultrasonic Imaging
- Acute Myocardial Infarction Research
- Cardiac Ischemia and Reperfusion
- Hemodynamic Monitoring and Therapy
- Cardiac Fibrosis and Remodeling
- Ultrasound and Hyperthermia Applications
- Hormonal Regulation and Hypertension
- Autophagy in Disease and Therapy
- Cardiac Structural Anomalies and Repair
- Plant Pathogens and Fungal Diseases
- Lipoproteins and Cardiovascular Health
- Advanced MRI Techniques and Applications
Gifu Heart Center
2015-2025
Amsterdam UMC Location University of Amsterdam
2017-2022
Amsterdam University Medical Centers
2019-2022
University of Amsterdam
2017-2022
Gifu University
2011-2020
Gifu University Hospital
2011-2019
Tokyo Metropolitan University
2018
Mansoura University
2018
Tohoku University
2018
The University of Tokyo
1976-2017
The purpose of this document is to make the output International Working Group for Intravascular Optical Coherence Tomography (IWG-IVOCT) Standardization and Validation available medical scientific communities, through a peer-reviewed publication, in interest improving diagnosis treatment patients with atherosclerosis, including coronary artery disease. optical coherence tomography (IVOCT) catheter-based modality that acquires images at resolution ∼10 μm, enabling visualization blood vessel...
Little is known about the association between autophagy and diabetic cardiomyopathy. Also unknown are possible distinguishing features of cardiac in type 1 2 diabetes. In hearts from streptozotocin-induced mice, diastolic function was impaired, though autophagic activity significantly increased, as evidenced by increases microtubule-associated protein light chain 3/LC3 LC3-II/-I ratios, SQSTM1/p62 (sequestosome 1) CTSD (cathepsin D), abundance vacuoles lysosomes detected...
Background — The purpose of the present study was to define whether integrated backscatter (IB) combined with conventional intravascular ultrasound (IVUS) makes tissue characterization coronary arterial plaques possible. Methods and Results IB-IVUS performed in arteries (total 18 segments) 9 patients at autopsy, findings were compared histology. RF signals, which digitized 2 GHz 8-bit resolution, obtained an IVUS system a 40-MHz catheter. IB values signal from region interest (ROI) (100-μm...
Ischemia is known to potently stimulate autophagy in the heart, which may contribute cardiomyocyte survival. In vitro, transfection with small interfering RNAs targeting Atg5 or Lamp-2 (an autophagy-related gene necessary, respectively, for initiation and digestion step of autophagy), specifically inhibited autophagy, diminished survival among cultured cardiomyocytes subjected anoxia significantly reduced their ATP content, confirming an autophagy-mediated protective effect against anoxia....
Active autophagy has recently been reported in doxorubicin-induced cardiotoxicity; here we investigated its pathophysiological role.Acute cardiotoxicity was induced green fluorescent protein-microtubule-associated protein 1 light chain 3 (GFP-LC3) transgenic mice by administering two intraperitoneal injections of 10 mg/kg doxorubicin with a day interval. A starvation group deprived food for 48 h before each injection to induce advance. Doxorubicin treatment caused left ventricular dilatation...
A major disadvantage of carotid artery stenting (CAS) compared to endarterectomy is the increased risk cerebral embolism. Thus, establishing a simple method discriminate fragile plaques on preoperative routine examination important. The present study examined whether high-intensity signal (HIS) in plaque time-of-flight (TOF) MRA, performed for screening, can at high embolism during CAS.In 30 patients treated using endarterectomy, relationships between pathological findings and TOF-MRA were...
Rationale: Multilineage-differentiating stress enduring (Muse) cells, pluripotent marker stage-specific embryonic antigen-3 + are nontumorigenic endogenous pluripotent-like stem cells obtainable from various tissues including the bone marrow. Their therapeutic efficiency has not been validated in acute myocardial infarction. Objective: The main objective of this study is to clarify intravenously infused rabbit autograft, allograft, and xenograft (human) marrow-Muse a infarction model their...
Background —It has been thought that the thrombi and bleeding in plaques occur after plaque rupture or endothelial damage from vessels with mild stenosis suddenly occlude lumen cause acute myocardial infarction (AMI). However, our hypothesis is may not lumen. Methods Results —The study group consisted of 20 patients who had coronary angiograms performed within 1 week (3±3 days) before AMI control 6 to 18 months (282±49 AMI. The features infarct-related segments (IRCS) at 3 days were presence...
Background The purpose of this study was to determine whether treatment with granulocyte colony-stimulating factor (G-CSF), which mobilizes endothelial progenitor cells from bone marrow, can safely improve the clinical outcomes patients atherosclerotic peripheral artery disease (PAD). Methods and Results Thirty-nine intractable PAD were randomly assigned 3 groups: a negative control group (n=12) treated conventional drug therapy; positive (n=13) therapy plus marrow transplantation (BMT);...
Background Integrated backscatter (IB) intravascular ultrasound (IVUS) and IVUS Virtual Histology (VH) have been developed for tissue characterization, but never compared directly. The purpose of this study was to compare the overall agreement between IB-IVUS IVUS-VH in characterization plaques from same coronary arterial cross-section. Methods Results Images were acquired 46 arteries 25 cadavers. Of a total 392 histology/IVUS image pairs, 152 pairs diagnosed as Stary's type III, IV, Va, Vb...
We investigated whether microRNA-145 (miR-145) has a cardioprotective effect in rabbit model of myocardial infarction (MI) and H9c2 rat cardiomyoblasts. Rabbits underwent 30 min coronary occlusion, followed by 2 days or wk reperfusion. Control microRNA (control group; 2.5 nmol/kg, n = 10) miR-145 (miR-145 group, encapsulated liposomes was intravenously administered immediately after the start cardiomyoblasts were transfected with miR-145. The MI size significantly smaller group than control...
Background: Metformin is a popular antidiabetic agent that also used to treat heart failure patients with type 2 diabetes mellitus. Several reports suggest metformin may have cardioprotective effects in without In the present study, we investigated possible therapeutic effect of and its underlying molecular mechanisms using δ-sarcoglycan-deficient mouse model dilated cardiomyopathy. Methods Results: Thirty-two-week-old mice exhibiting established cardiomyopathy extensive left ventricular...
Background:Multilineage differentiating stress-enduring (Muse) cells are SSEA3+and CD105+double-positive pluripotent-like stem cells. We aimed to examine the mobilization of Muse into peripheral blood after acute myocardial infarction (AMI) and their effects on left ventricular (LV) function remodeling.
Abstract Aims This study aimed to determine the effects of a proprotein convertase subtilisin-kexin type 9 inhibitor (PCSK9i) on coronary plaque volume and lipid components in patients with history artery disease (CAD). Methods results prospective, open-label, single-centre analysed non-culprit segments using near-infrared spectroscopy-intravascular ultrasound (NIRS-IVUS) at baseline follow-up angiography. Following changes lipid-lowering treatment based most recent guideline, enrolled...
Sporotrichosis is caused by a thermo-dependent dimorphic fungus, Sporothrix schenckii. The major clinical manifestations occur in the skin; however, cases of visceral have also been increasingly reported with some being observed immune compromised patients. Different virulence individual S. schenckii strain as well status host could contribute to form such different manifestations. Thus, purpose study was investigate whether be factor for difference. We investigated interactions between...