Kazutaka Uchida
A5101588979- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Venous Thromboembolism Diagnosis and Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Stroke Rehabilitation and Recovery
- Intracranial Aneurysms: Treatment and Complications
- Peripheral Artery Disease Management
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Health and Disease Prevention
- Antiplatelet Therapy and Cardiovascular Diseases
- Vascular Malformations Diagnosis and Treatment
- Cardiac Arrhythmias and Treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Moyamoya disease diagnosis and treatment
- Medical Imaging and Analysis
- Fluorine in Organic Chemistry
- Hormonal Regulation and Hypertension
- Lipoproteins and Cardiovascular Health
- Cardiac Imaging and Diagnostics
- Ocular Infections and Treatments
- Hormonal and reproductive studies
- Meningioma and schwannoma management
- Cerebral Venous Sinus Thrombosis
- Biochemical and Molecular Research
- Drug Transport and Resistance Mechanisms
Hyogo University
2022-2025
University of Calgary
2024-2025
Medical University of South Carolina
2023-2025
Foothills Medical Centre
2024-2025
Hyogo Medical University
2015-2024
International University of Health and Welfare
2012-2022
Boston University
2022
Boston Medical Center
2022
Cooper University Hospital
2022
Toyohashi University of Technology
2019
Endovascular therapy for acute ischemic stroke is generally avoided when the infarction large, but effect of endovascular with medical care as compared alone large strokes has not been well studied.
BackgroundWhether the large effect size of endovascular thrombectomy (EVT) for stroke due to large-vessel occlusion applies medium-vessel is unclear.MethodsIn a multicenter, prospective, randomized, open-label trial with blinded outcome evaluation, we assigned patients acute ischemic who presented within 12 hours from time that they were last known be well and had favorable baseline noninvasive brain imaging receive EVT plus usual care or alone. The primary was modified Rankin scale score...
To assess the significance of reversed circadian blood pressure (BP) rhythms as a predictive factor vascular events in NIDDM, vital status after an average 4-year follow-up was determined 325 NIDDM subjects whom BP profile had been monitored between 1988 and 1996. Circadian rhythm analyzed by COSINOR (a compound word for cosine vector) method, previously described. After exclusion 37 dropped-out subjects, 288 were recruited to further analysis, which 201 normal (group N) remaining 87 one R)....
Endovascular therapy (EVT) has been found to reduce functional disability in patients with acute stroke due large-vessel occlusion. However, the extent of ischemic region, measured using Alberta Stroke Program Early Computed Tomography Scores, may limit efficacy EVT.To compare and safety EVT according ASPECTS 3 or less vs 4 5.The Recovery by Salvage for Cerebral Ultra-acute Embolism-Japan Large Ischemic Core Trial (RESCUE-Japan LIMIT) was an open-label randomized clinical trial conducted...
Abstract Aims Early studies have shown that magnesium intake decreases the risk of Type 2 diabetes, but results are still inconsistent. We prospectively examined association between and incidence diabetes in a general Japanese population. Methods A total 1999 subjects without aged 40–79 years who underwent 75‐g oral glucose tolerance test were followed up for mean 15.6 years. Results During follow‐up, 417 developed diabetes. The age‐ sex‐adjusted significantly decreased with increasing...
Background Endovascular therapy has been shown to be effective in patients with acute cerebral large‐vessel occlusion, but real‐world efficacies are unknown. Methods and Results We conducted a prospective registry at 46 centers between October 2014 January 2017. Eligible were those who aged 20 years or older, hospitalized within 24 hours of the onset. enrolled both consecutive treated without endovascular therapy. included thrombectomy, balloon angioplasty, stenting, local fibrinolysis,...
Background and Purpose- Sex differences in the management outcomes of acute ischemic stroke with large vessel occlusion are unknown era endovascular therapy (EVT). This study investigated these RESCUE (Recovery by Endovascular Salvage for Cerebral Ultra-Acute Embolism)-Japan Registry 2 patient database. Methods- RESCUE-Japan registered patients who were admitted within 24 hours onset enrolled this study. We estimated likelihood to receive EVT according sex. The primary outcome was good...
BACKGROUND: Studies comparing bridging intravenous thrombolysis (IVT) with direct endovascular therapy (EVT) in patients acute ischemic stroke who present late are limited. We aimed to compare the clinical outcomes and safety of IVT due anterior circulation large vessel occlusion underwent EVT 6 24 hours after time last known well. METHODS: enrolled a National Institutes Health Stroke Scale score ≥6 from 20 centers across 10 countries multicenter retrospective CLEAR study (CT for Late...
BACKGROUND: We aimed to examine the boundary of ischemic core volume in patients undergoing endovascular thrombectomy (EVT) versus those receiving medical management determine minimum optimal size for favorable treatment outcomes. METHODS: This is a prespecified substudy RESCUE-Japan LIMIT (Recovery by Endovascular Salvage Cerebral Ultra-Acute Embolism-Japan Large Ischemic Core Trial). Patients with large vessel occlusion were enrolled between November 2018 and September 2021 National...
Perivascular regions of the brain harbor multipotent stem cells. We previously demonstrated that pericytes near blood vessels also develop multipotency following experimental ischemia in mice and these ischemia-induced cells (iSCs) can contribute to neurogenesis. However, it is essential understand traits iSCs poststroke human for possible applications cell-based therapies stroke patients. In this study, we report first time be isolated from brain. Putative were derived tissue obtained...
Background and Purpose— Endovascular therapy is effective against acute cerebral large vessel occlusion (LVO). However, many patients do not receive such interventions because of the lack timely identification type stroke. If types stroke (any stroke, LVO, intracranial hemorrhage [ICH], subarachnoid [SAH]) were to be predicted at prehospital stage, better access appropriate would possible. Japan Urgent Stroke Triage (JUST) score was clinical prediction rule classify suspected into different...
Endovascular therapy (EVT) is strongly recommended for acute cerebral large vessel occlusion with the Alberta Stroke Program Early CT Score (ASPECTS) ≥6 due to of internal carotid artery or M1 segment middle artery. However, effect EVT patients who have ischemic core ASPECTS ≤5 (0–5) was not established. The purpose this study elucidate outcomes core.Based on data Recovery by Salvage Cerebral Ultra-Acute Embolism Japan Registry 2, and pretreatment 0 5 noncontrast diffusion-weighted image...
The increased risk of intracranial hemorrhage with multiple passes in endovascular therapy (EVT) for large vessel occlusion a ischemic core is concern. We explored the effect number EVT on patients randomized clinical trial.This post hoc study was secondary analysis RESCUE-Japan LIMIT, which trial comparing and medical treatment alone core. grouped according to successful reperfusion (modified Thrombolysis Cerebral Infarction score, ≥2b) 1, 2, 3 7 failed 0-2a) after any pass group, these...
Background The health economic benefit of endovascular treatment (EVT) in addition to best medical management for acute ischemic stroke with large core is uncertain. Purpose To assess the cost-effectiveness EVT plus versus alone treating vessel occlusion and a baseline Alberta Stroke Program Early CT Score (ASPECTS) 3-5. Materials Methods This secondary analysis randomized RESCUE-Japan LIMIT (Recovery by Endovascular Salvage Cerebral Ultra-acute Embolism-Japan Large Ischemic Core Trial),...
Background and Purpose We compared the outcomes of endovascular therapy (EVT) in an extended time window patients with large-vessel occlusion (LVO) between without pre-stroke disability.Methods In this prespecified analysis multinational CT for Late Endovascular Reperfusion study (66 participating sites, 10 countries 2014 2022), we analyzed data from acute ischemic stroke a modified Rankin Scale (mRS) score 0–4 LVO who underwent EVT 6–24 hours last seen well. The primary outcome was...
With the expanding eligibility for endovascular therapy (EVT) of patients presenting in late window (6-24 hours after last known well), we aimed to derive a score predict favorable outcomes associated with EVT versus best medical management.
Background: There are limited therapeutic options in cases of failed reperfusion (modified thrombolysis cerebral infarction [mTICI] score < 2b) after stent-retriever and/or aspiration based endovascular treatment (EVT) for acute ischemic stroke. Despite the absence data supporting its use, rescue therapy (balloon angioplasty stent implantation) is often utilized such cases. Studies to large vessel occlusions, while outcomes and complications medium/distal occlusions (MDVOs) have not been...
This retrospective observational multicentre cohort study compared the rate of postoperative cystoid macular oedema (CME) between two intraocular lens (IOL) scleral fixation (SFIOL) techniques: a flanged IOL technique (Yamane technique) and suture transscleral (conventional technique). The included 207 eyes with CME that had undergone SFIOL were observed for > 12 weeks January 2019 2021. primary endpoint was comparison at 3 months groups. Secondary endpoints best-corrected visual acuity...
Abstract Background Cataract surgeries are increasing annually, making appropriate medical management essential. The routine use of systemic antimicrobial agents for preventing surgical site infections lacks strong evidence and may increase the risk drug-resistant bacteria adverse events. This study examined impact discontinuing cefazolin (CEZ) administration during perioperative period cataract surgery on incidence postoperative events costs. Methods Inpatient patients were divided into two...
Introduction: Randomized clinical trials evaluating the effects of endovascular treatment (EVT) for medium vessel occlusion (MeVO) are ongoing. However, it remains unclear how clinicians determine indication EVT in MeVO cases real-world practice Hypothesis: We hypothesize that actual practice, there is a threshold symptoms and perfusion imaging findings guide decision to intervene with MeVO. Methods: conducted single-center retrospective registry from April 2019 2024, enrolling consecutive...
Background: We investigate whether the NIHSS at 24 hours could serve as an alternative primary outcome measure in acute ischemic stroke trials, and combining 90-day modified Rankin Score (mRS) 24-hour a hierarchical enhance detection of treatment effect, using EVT exemplary study intervention. Methods: Post-hoc analysis from HERMES collaboration that pooled data 7 randomized controlled trials. Validity surrogate for mRS was assessed causal mediation model (Figure 1). A 7-point ordinal score...