A5041468000- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Glaucoma and retinal disorders
- Retinal and Optic Conditions
- Retinal and Macular Surgery
- Ocular Diseases and Behçet’s Syndrome
- Intraocular Surgery and Lenses
- Retinal Development and Disorders
- Ocular Infections and Treatments
- Vascular Malformations Diagnosis and Treatment
- Ophthalmology and Eye Disorders
- Ophthalmology and Visual Impairment Studies
- Traumatic Ocular and Foreign Body Injuries
- Endoplasmic Reticulum Stress and Disease
- Corneal surgery and disorders
- Ocular Surface and Contact Lens
- Cerebral Venous Sinus Thrombosis
- Mitochondrial Function and Pathology
- Drug-Induced Ocular Toxicity
- Optical Coherence Tomography Applications
- Apelin-related biomedical research
- Botulinum Toxin and Related Neurological Disorders
- Autophagy in Disease and Therapy
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Ocular Oncology and Treatments
Hyogo University
2022-2025
Hyogo Medical University
2017-2024
Japan Clinical Cancer Research Organization
2024
Osaka University
2011-2022
Sumitomo Hospital
2013-2021
Novartis (Japan)
2021
Japan Society for the Promotion of Science
2012
Gunma University
2010
RIKEN
2010
Osaka University of Pharmaceutical Sciences
2010
When accumulation of a malfolded protein in the endoplastic reticulum (ER) is induced by various adverse conditions, such as hypoxia, glucose starvation, and perturbation calcium homeostasis, cells respond to stress increasing transcription genes encoding ER molecular chaperones, process known unfolded response. The signaling initiated IRE1s, sensors. Alternatively, excessive results apoptosis. Caspase-12 be essential for this stress-induced In study, we analyzed detailed regulatory...
To develop consensus terminology in the setting of polypoidal choroidal vasculopathy (PCV) and to validate a set diagnostic criteria not requiring indocyanine green angiography (ICGA) for differentiating PCV from typical neovascular age-related macular degeneration (nAMD) based on combination OCT color fundus photography findings.Evaluation test results.Panel retina specialists.As part Asia-Pacific Ocular Imaging Society, an international group experts surveyed discussed published literature...
<h3>Aims:</h3> The aim of the study was to assess short-term efficacy intravitreal injections bevacizumab for polypoidal choroidal vasculopathy (PCV). <h3>Methods:</h3> Intravitreal (1 mg) injected into 11 eyes patients with PCV in this retrospective, interventional case series. main outcome measure change vessels on indocyanine green angiography (IA) 3 months after injection. foveal height determined by optical coherence tomography and best-corrected visual acuity (BCVA) also were evaluated...
During development, the retinal vasculature grows toward hypoxic areas in an organized fashion. By contrast, ischemic retinopathies, new blood vessels grow out of surfaces without ameliorating hypoxia. Restoration proper angiogenic directionality would be great benefit to reoxygenize retina and resolve disease pathogenesis. Here, we show that binding semaphorin 3E (Sema3E) ligand transmembrane PlexinD1 receptor initiates a signaling pathway normalizes both developing retinas retinopathy. In...
To report complications in patients after intravitreal injection of bevacizumab to treat ocular diseases associated with vascular endothelial growth factor.We retrospectively reviewed the systemic and that developed within 2 months each 707 (1300 injections) intraocular neovascularization or macular oedema.Nine (1.27%) eight (1.13%) occurred patients. The included corneal abrasion (n = 2), chemosis lens injury 1), inflammation retinal pigment epithelial tear 1) acute vision loss 1). cerebral...
To study the choroidal thickness profile using high-penetration optical coherence tomography in central serous chorioretinopathy (CSC).Thirty-five eyes of 27 subjects with CSC and 35 healthy, age-matched control were included. We observed choroid prototype tomography. Fluorescein angiography indocyanine green performed to identify location activity. The thicknesses was measured manually various conditions or locations, maps obtained from cube scans calculating software composed nine sectors...
To compare the 1-year results of initial or deferred photodynamic therapy (PDT) combined with intravitreal ranibizumab (IVR) for eyes polypoidal choroidal vasculopathy.Prospectively, 72 men treatment-naive vasculopathy were randomized to later PDT IVR. In both groups, 2 additional monthly IVR followed. From Month 3, and administered according retreatment criteria. Mean changes in best-corrected visual acuity between baseline 12 central retinal thickness, rate showing regression lesions,...
A panel of 21 international experts are formed by the Asia-Pacific Vitreo-retina Society to work out consensus and guidelines on polypoidal choroidal vasculopathy (PCV). PCV is a common subtype neovascular age-related macular degeneration more prevalent in Asian populations. Recent advancement imaging technology allows greater understanding disease process PCV. Furthermore, non-indocyanine green angiography features optical coherence tomography have been validated for diagnosis treatment...
To assess the efficacy and safety of an intravitreal injection bevacizumab (Avastin(R)) for myopic choroidal neovascularisation (mCNV).Intravitreal (1 mg) was injected into eight eyes patients with mCNV in this non-randomised, interventional case series. The best-corrected visual acuity (BCVA) measured optical coherence tomography (OCT) fluorescein angiography findings were examined before after treatment. minimum follow-up time 3 months.The mean BCVA 0.26 treatment 0.51 at last visit (p =...
Objective— Apelin is an endogenous ligand for the G protein-coupled receptor, APJ, and participates in multiple physiological processes. To identify roles of apelin, we investigated phenotype apelin-deficient (apelin-KO) mice. Methods Results— Apelin-KO mice showed impaired retinal vascularization ocular development, which were analyzed by histology, immunohistochemistry, real-time polymerase chain reaction, mouse corneal micropocket assay. significantly early postnatal period. Retinal...
To clarify the characteristics of choroidal neovascularization (CNV) due to myopic CNV (mCNV) and relation lacquer crack (LC) formation.Thirty-seven eyes with mCNV underwent fluorescein angiography (FA) indocyanine green (ICGA) using Heidelberg Retina Angiograph 2 (HRA2; Heidelberg, Germany). was detected by FA ICGA; LCs were late-phase ICGA.Thirty-five (95%) had classic mCNV, (5%) occult CNV. developed in 35 37 eyes. In 33 (94%), originated from LCs; other small horizontal dotlike LCs, but...
Objective— To investigate the role of endogenous apelin in pathological retinal angiogenesis. Methods and Results— The progression ischemic diseases, such as diabetic retinopathy, is closely associated with angiogenesis, mainly induced by vascular endothelial growth factor (VEGF) erythropoietin. Although antiangiogenic therapies using anti-VEGF drugs are effective treating neovascularization, they show a transient efficacy cause general adverse effects. New therapeutic target molecules...