A5011320252- Retinal Diseases and Treatments
- Retinal and Macular Surgery
- Glaucoma and retinal disorders
- Retinal and Optic Conditions
- Intraocular Surgery and Lenses
- Retinal Imaging and Analysis
- Neuroscience and Neural Engineering
- Retinal Development and Disorders
- Photoreceptor and optogenetics research
- Vascular Malformations Diagnosis and Treatment
- Ocular Diseases and Behçet’s Syndrome
- Advanced Memory and Neural Computing
- EEG and Brain-Computer Interfaces
- Retinopathy of Prematurity Studies
- Cerebral Venous Sinus Thrombosis
- Ocular Infections and Treatments
- Polymer Surface Interaction Studies
- Ophthalmology and Visual Impairment Studies
- Laser-induced spectroscopy and plasma
- Ocular Surface and Contact Lens
- Hydrogels: synthesis, properties, applications
- Barrier Structure and Function Studies
- Laser-Plasma Interactions and Diagnostics
- Electrospun Nanofibers in Biomedical Applications
- Neuropeptides and Animal Physiology
Osaka University
2015-2024
Gifu University
2022-2024
Toray Industries, Inc. (Japan)
2014-2023
Ogaki Municipal Hospital
2023
Toray (United States)
2022
Nara Medical University
2022
Weatherford College
2022
Ophthalmology Associates (United States)
2011-2021
Osaka University Hospital
2019
Advanced Device Technology (United States)
2018
Drusen are extracellular deposits that accumulate below the retinal pigment epithelium on Bruch's membrane and risk factors for developing age-related macular degeneration (AMD). The progression of AMD might be slowed or halted if formation drusen could modulated. To work toward a molecular understanding formation, we have developed method isolating microgram quantities proteome analysis. Liquid chromatography tandem MS analyses preparations from 18 normal donors five identified 129...
Immune attacks are key issues for cell transplantation. To assess the safety and immune reactions after iPS cells-derived retinal pigment epithelium (iPS-RPE) transplantation, we transplanted HLA homozygote iPS-RPE cells established at an bank in HLA-matched patients with exudative age-related macular degeneration. In addition, local steroids without immunosuppressive medications were administered. We monitored rejections by routine ocular examinations as well lymphocytes-graft reaction...
<h3>Aims:</h3> The aim of the study was to assess short-term efficacy intravitreal injections bevacizumab for polypoidal choroidal vasculopathy (PCV). <h3>Methods:</h3> Intravitreal (1 mg) injected into 11 eyes patients with PCV in this retrospective, interventional case series. main outcome measure change vessels on indocyanine green angiography (IA) 3 months after injection. foveal height determined by optical coherence tomography and best-corrected visual acuity (BCVA) also were evaluated...
To examine the safety and effectiveness of a retinal prosthesis that is implanted semichronically in two patients with advanced retinitis pigmentosa (RP).Two eyes RP had sclera pocket one eye. The visual acuity both before implantation was bare light perception. Phosphenes were elicited by suprachoroidal-transretinal stimulation (STS). internal devices STS under skin on temporal side head, 49 electrode-array scleral Biphasic electrical pulses (duration, 0.5 ms; frequency, 20 Hz) delivered...
To report complications in patients after intravitreal injection of bevacizumab to treat ocular diseases associated with vascular endothelial growth factor.We retrospectively reviewed the systemic and that developed within 2 months each 707 (1300 injections) intraocular neovascularization or macular oedema.Nine (1.27%) eight (1.13%) occurred patients. The included corneal abrasion (n = 2), chemosis lens injury 1), inflammation retinal pigment epithelial tear 1) acute vision loss 1). cerebral...
Purpose: To investigate microvascular changes in the superficial capillary plexus (SCP) and deep (DCP) eyes with resolved branch retinal vein occlusion (BRVO) their association best-corrected visual acuity (BCVA). Methods: Eighty-five (82 consecutive patients) BRVO after resolution of macular edema were retrospectively evaluated. All patients underwent optical coherence tomography angiography (OCTA) for assessment changes, including telangiectasia, microaneurysm, disruption foveal avascular...
Purpose: To determine the feasibility of a 49-channel suprachoroidal–transretinal stimulation (STS) retinal prosthesis that was implanted for 1 year. Methods: Three patients with advanced retinitis pigmentosa (RP) and less than or equal to hand motion (HM) vision were studied. A STS system in scleral pocket, stability prosthesis, adverse events, its efficacy investigated. Results: The electrode array pocket located under parafoveal area through incision at 14 mm patient (Pt) 1, 16 Pt 2, 18 3...
To assess the efficacy and safety of an intravitreal injection bevacizumab (Avastin(R)) for myopic choroidal neovascularisation (mCNV).Intravitreal (1 mg) was injected into eight eyes patients with mCNV in this non-randomised, interventional case series. The best-corrected visual acuity (BCVA) measured optical coherence tomography (OCT) fluorescein angiography findings were examined before after treatment. minimum follow-up time 3 months.The mean BCVA 0.26 treatment 0.51 at last visit (p =...
Laser-driven expansion of pure-tin microdroplets was demonstrated to produce an efficient and low-debris extreme-ultraviolet (EUV) light source. The pre-expansion is indispensable for resolving the considerable mismatch between optimal laser spot diameter (∼300μm) (∼20μm) containing minimum-mass Sn fuel generating required EUV radiant energy (∼10mJ/pulse). Explosive attained by using a prepulse, whose intensity at least 3×1011W∕cm2. expanded microdroplet irradiated with CO2 pulse generate...
For applications where degradable polymers are likely to have extended blood contact, it is often important for these materials exhibit high levels of thromboresistance. This can be achieved with surface modification approaches, but such modifications may transient degradation. Alternatively, polymer design altered that the bulk thromboresistant and this maintained Toward end a series biodegradable, elastic polyurethanes (PESBUUs) containing different zwitterionic sulfobetaine (SB) content...
As part of ongoing efforts to better understand the role protein oxidative modifications in retinal pathology, nitration retina has been compared between rats exposed damaging light or maintained dark. In course research, Western methodology for detecting nitrotyrosine-containing proteins improved by incorporating chemical reduction nitrotyrosine aminotyrosine, allowing specific and nonspecific immunoreactivity be distinguished. A liquid chromatography MS/MS detection strategy was used that...
Nitric oxide (NO) generation was induced in rats by Escherichia coli lipopolysaccharide (LPS) as detected electron spin resonance (ESR) signals of NO hemoglobin (HbNO). However, there were inconsistencies ESR spectral shape among them. We have therefore carried out a systematic study to clarify the vivo changes. First, spectra alpha-NO heme species had distinct three-line hyperfine structure venous blood but not arterial all treated with tumor necrosis factor, interleukin-1, and/or LPS, and...
Purpose: To investigate the changes in retinal microvasculature during course of anti-VEGF therapy eyes with macular edema due to vein occlusion (RVO) and their association visual outcomes. Methods: The vessel density (VD) foveal avascular zone (FAZ) area superficial capillary plexus (SCP) deep (DCP) were quantitatively measured by optical coherence tomography angiography (OCTA) 48 consecutive RVO before 1, 3, 6, 9, 12 months after therapy. Anti-VEGF was performed either ranibizumab or...
In acute kidney injury caused by sepsis (septic AKI), excessive production of inflammatory mediators is believed to be involved in deterioration the disease. Renal replacement therapy using a polymethyl methacrylate (PMMA) membrane hemofilter improves pathological condition septic AKI adsorbing and removing cytokines. However, adsorption properties PMMA are unclear. this study, we comprehensively analyzed 48 different cytokines human plasma polysulfone (PS) membranes. Seventy-nine percent...
Abstract Rationale: Multiple evanescent white dot syndrome (MEWDS) is an acute, usually unilateral, retinal disorder of unknown etiology that predominantly occurs in healthy young women. We report a case bilateral asymmetric MEWDS developed following the first vaccination for coronavirus-19 and worsened after second vaccination. Patient concerns: A 30-year-old Japanese woman was examined eye clinic blurred vision her left 1 week duration. Thirteen days before examination, she had received...