A5028235253- Neuroscience and Neural Engineering
- Photoreceptor and optogenetics research
- Retinal Diseases and Treatments
- Retinal and Optic Conditions
- EEG and Brain-Computer Interfaces
- Advanced Memory and Neural Computing
- Retinal Imaging and Analysis
- Retinal Development and Disorders
- Retinal and Macular Surgery
- Vascular Malformations Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Colorectal Cancer Surgical Treatments
- Advanced Fluorescence Microscopy Techniques
- Intraocular Surgery and Lenses
- Gastric Cancer Management and Outcomes
- Blood Coagulation and Thrombosis Mechanisms
- Spectroscopy Techniques in Biomedical and Chemical Research
- Glaucoma and retinal disorders
- Cerebral Venous Sinus Thrombosis
- Photoacoustic and Ultrasonic Imaging
- Ocular Diseases and Behçet’s Syndrome
- Pregnancy and preeclampsia studies
- Intestinal Malrotation and Obstruction Disorders
- Soft tissue tumor case studies
- Glycosylation and Glycoproteins Research
Osaka Rosai Hospital
2022-2025
Mie University
2023-2024
Osaka University
2015-2024
National Institute of Advanced Industrial Science and Technology
2021
Asociacion Para Evitar la Ceguera en México Hospital Dr. Luis Sánchez Bulnes
2015
NTT WEST Osaka Hospital
2015
Ophthalmology Associates (United States)
2011
To examine the safety and effectiveness of a retinal prosthesis that is implanted semichronically in two patients with advanced retinitis pigmentosa (RP).Two eyes RP had sclera pocket one eye. The visual acuity both before implantation was bare light perception. Phosphenes were elicited by suprachoroidal-transretinal stimulation (STS). internal devices STS under skin on temporal side head, 49 electrode-array scleral Biphasic electrical pulses (duration, 0.5 ms; frequency, 20 Hz) delivered...
Purpose: To determine the feasibility of a 49-channel suprachoroidal–transretinal stimulation (STS) retinal prosthesis that was implanted for 1 year. Methods: Three patients with advanced retinitis pigmentosa (RP) and less than or equal to hand motion (HM) vision were studied. A STS system in scleral pocket, stability prosthesis, adverse events, its efficacy investigated. Results: The electrode array pocket located under parafoveal area through incision at 14 mm patient (Pt) 1, 16 Pt 2, 18 3...
Purpose: To investigate the changes in retinal microvasculature during course of anti-VEGF therapy eyes with macular edema due to vein occlusion (RVO) and their association visual outcomes. Methods: The vessel density (VD) foveal avascular zone (FAZ) area superficial capillary plexus (SCP) deep (DCP) were quantitatively measured by optical coherence tomography angiography (OCTA) 48 consecutive RVO before 1, 3, 6, 9, 12 months after therapy. Anti-VEGF was performed either ranibizumab or...
Desmoplastic small round cell tumor (DSRCT) is a highly malignant sarcoma and an extremely rare tumor, predominantly found in the abdominal pelvic regions. Here, we report case of patient who underwent surgical treatment for multiple desmoplastic intestine. A 38-year-old male visited our hospital after health check revealed positive occult blood his stool colonoscopy tumors descending colon sigmoid colon. Biopsy results poorly differentiated adenocarcinoma. Chest enhanced computed tomography...
We propose and characterize a CMOS LSI-based neural stimulator for retinal prosthesis technology. The is based upon multichip architecture in which small-sized stimulators named ldquounit chipsrdquo are organized on flexible substrate. designed unit chip with an on-chip light-sensing circuitry. verified that all the functions implemented worked correctly can be used as multisite image-based patterned stimulation. also demonstrated light-controlled stimulation first time <i...
Aims To evaluate long-term reconstructive changes in foveal microstructures and their associations with visual improvement eyes surgically closed macular holes (MHs). Methods Twenty-eight of 28 patients who underwent successful idiopathic MH repair were retrospectively studied. Best-corrected acuity (BCVA) spectral-domain optical coherence tomography images examined preoperatively 1, 3, 6, 12, 24 36 months postoperatively. Correlations between postoperative BCVA parameters relating to the...
Abstract We investigated changes in retinal vascular area and the foveal avascular zone (FAZ) after intravitreal aflibercept diabetic macular edema (DME) association of these with visual outcomes. The superficial capillary plexus (SCP) deep (DCP) FAZ were measured using optical coherence tomography angiography (OCTA) 23 eyes patients DME, before aflibercept. Overall, there was no significant change or FAZ. Better BCVA treatment significantly associated larger SCP DCP, both at baseline (R 2 =...
To investigate the feasibility of implanting a newly developed suprachoroidal-transretinal stimulation (STS) prosthesis in dogs and to determine its biocompatibility stability over 3-month period.The STS system consisted an array 49 electrodes (nine were active), intravitreal return electrode, extraocular microstimulator. The 49-electrode was implanted into scleral pocket each three healthy beagle dogs. Color fundus photography, fluorescein angiography, electroretinography, functional...
Abstract It is important to evaluate the clinical importance of both CD8 T cells and CD4 expression simultaneously because they have crucial networks in tumour targeting immune responses. In 97 RCC patients, RNA sequencing gene set enrichment analysis based on levels PD-1 TIM-3 implied that populations PD-1+TIM-3+ PD-1lowTIM-3 + were characterized as exhausted regulatory cells, respectively. These significantly upregulated patients with higher WHO/ISUP grade (grades 3, 4) ( P < 0.001)....
Purpose To investigate the effect of an intravitreally administered CCR2 antagonist, INCB3344, on a mouse model choroidal neovascularization (CNV). Methods CNV was induced by laser photocoagulation Day 0 in wild type mice. INCB3344 or vehicle immediately after application. On 14, areas were measured retinal pigment epithelium (RPE)-choroid flat mounts and histopathologic examination performed 7 µm-thick sections. Macrophage infiltration evaluated immunohistochemistry RPE-choroid quantified...
To characterize wide-field optical coherence tomography angiography (OCTA) features of retinal nonperfusion in eyes with branch vein occlusion (BRVO).Automated scanning five 12 × 12-mm areas swept-source OCTA and fluorescein (FA) images was performed a consecutive case series 27 patients BRVO this institutional cross-sectional study. The correlation between the detected by both examinations assessed. Panoramic obtained scans were binarized or skeletonized, associations vascular parameters...
Purpose. To develop a middle-sized animal model of outer retinal degeneration and to evaluate the effectiveness suprachoroidal-transretinal stimulation (STS) in eliciting cortical potentials from this model. Methods. Twelve rabbits were intravenously injected with 0.47 mg/kg verteporfin retinas irradiated red light for 90 minutes. Fluorescein angiography full-field focal electroretinography (ERG) performed at 7 28 days after irradiation. Electrically evoked (EEPs) elicited by electrical...
A complementary metal-oxide semiconductor (CMOS)-based multichip flexible neural stimulator for retinal prostheses was developed. The is capable of simultaneous multisite stimulation. An on-chip stimulation generator implemented on the “unit chip,” which core device stimulator. performance CMOS circuitry characterized. new structure and packaging process in vivo a rabbit's retina successfully performed functionality confirmed.
To investigate vascular perfusion and foveal avascular zone area in the superficial capillary plexus (SCP) deep (DCP) after intravitreal aflibercept therapy central retinal vein occlusion eyes their association with best-corrected visual acuity.Thirty-five subjects macular edema were evaluated. After resolution following aflibercept, underwent optical coherence tomography angiography to measure SCP DCP within a 3 × 3-mm area. Correlations between acuity measurements examined.After therapy,...
To compare the anatomic and functional outcomes of pars plana vitrectomy (PPV) for treating rhegmatogenous retinal detachments (RRDs) between two groups with without postoperative prone positioning.This retrospective cohort study included 142 eyes patients a primary RRD. All underwent PPV 20% sulfur hexafluoride gas tamponade were divided into groups: that did not maintain position postoperatively. followed more than 3 months. The main outcome measures best-corrected visual acuity (BCVA),...
To document enlarged neovascularization elsewhere (NVE) quantitatively and morphologically using widefield swept-source (SS) OCT angiography (OCTA) with vitreoretinal interface (VRI) slab images.Retrospective, observational imaging study.The study included 46 NVE examples in 25 eyes of 21 consecutive patients who demonstrated severe proliferative diabetic retinopathy between March 2018 June 2020 at Osaka University Hospital.All underwent ophthalmologic examination, including ultra-widefield...
Direct photocoagulation reduces the central foveal thickness (CFT) in cases with chronic branch retinal vein occlusion (BRVO) of longer than 12 months duration. Photo-coagulation might be effective for macular edema due to occlusion.The aim was investigate effect direct treating associated BRVO.This study a noncomparative, pilot interventional case series. We examined CFT and best-corrected visual acuity over 6 patients BRVO treated photocoagulation.Sixteen eyes 16 had been (mean follow-up...
A therapeutic guideline for sigmoid volvulus (SV) has not been established, and the most recommended surgical procedure SV determined. Our objective is to assess usability of elective laparoscopic sigmoidectomy feasibility single-incision surgery following endoscopic reduction. typically affects elderly accounts 1% 7% intestinal obstructions in Western countries. We report on 3 patients with who underwent reduction, we first describe single-port SV. discuss (a 79-year-old male, an...