A5084059032- Neuroscience and Neural Engineering
- EEG and Brain-Computer Interfaces
- Advanced Memory and Neural Computing
- Photoreceptor and optogenetics research
- Analytical Chemistry and Sensors
- CCD and CMOS Imaging Sensors
- Retinal Development and Disorders
- Ocular and Laser Science Research
- Gaze Tracking and Assistive Technology
- Tactile and Sensory Interactions
- Advanced Sensor and Energy Harvesting Materials
- Electrochemical Analysis and Applications
- Neural dynamics and brain function
- Conducting polymers and applications
- Genetic and Kidney Cyst Diseases
- Ophthalmology and Visual Impairment Studies
- Neurological disorders and treatments
- Retinal and Macular Surgery
- Ultrasound in Clinical Applications
- Pediatric Urology and Nephrology Studies
- Intraocular Surgery and Lenses
- Transcranial Magnetic Stimulation Studies
- Multiple and Secondary Primary Cancers
- Cardiac Imaging and Diagnostics
- Electrodeposition and Electroless Coatings
Nara Institute of Science and Technology
2014-2025
Nidek (Japan)
2016-2025
Institut de la Vision
2008-2024
Instituto da Visão
2008-2024
Initiatives (Denmark)
2024
Nagoya University
2002
Tohoku University
1971-1998
Sendai Shakai Hoken Hospital
1990-1996
Seiko Holdings (Japan)
1980
Purpose: To determine the feasibility of a 49-channel suprachoroidal–transretinal stimulation (STS) retinal prosthesis that was implanted for 1 year. Methods: Three patients with advanced retinitis pigmentosa (RP) and less than or equal to hand motion (HM) vision were studied. A STS system in scleral pocket, stability prosthesis, adverse events, its efficacy investigated. Results: The electrode array pocket located under parafoveal area through incision at 14 mm patient (Pt) 1, 16 Pt 2, 18 3...
Attempts have been made to apply ultrasono-cardiotomography patients with congenital and acquired heart diseases.Ultrasono-cardiotomography enables a clear cross-section picture of the great vessels in various diseases as well normal subjects.Abnormalities anatomical structure such hypertrophy myocardium, enlargement cardiac chambers, septal defect at atrial or ventricular levels can also be seen.The findings from ultrasono-cardiotomograms are good agreement those found resected mitral...
Abstract To advance the practical application of retinal prostheses with high spatial resolution through parallel stimulation, we developed a dynamic power supply voltage control system designed to enable stable constant-current stimulation in vivo, regardless number active points. The proposed prosthesis integrates CMOS chip, containing current sources and electrode selection circuits, into array implanted eye. This configuration facilitates individual over 1000 electrodes minimal wiring....
We propose and characterize a CMOS LSI-based neural stimulator for retinal prosthesis technology. The is based upon multichip architecture in which small-sized stimulators named ldquounit chipsrdquo are organized on flexible substrate. designed unit chip with an on-chip light-sensing circuitry. verified that all the functions implemented worked correctly can be used as multisite image-based patterned stimulation. also demonstrated light-controlled stimulation first time <i...
This paper describes the technological developments underlying realization of a reliable and reproducible microchip-based stimulator with large number stimulus electrodes. A over 500 electrodes for suprachoroidal transretinal stimulation (STS) is proposed in this paper, an example presented. To enhance reliability reproducibility such array, we introduce flip-chip bonding technique place microchips on reverse side substrate. square microchip size 600 microm was fabricated using 0.35 standard...
Continuous monitoring of the crustal tilt is one most effective approaches for purpose earthquake prediction. Drilling a borehole not so expensive as construction an underground vault, which necessary installation water-tube tiltmeters and horizontal pendulum tiltmeters, station possible to be made even in plain area. The National Research Center Disaster Prevention has only developed boreholetype tiltmeter itself but improved drilling techniques methods tiltmeter. force-balanced down-hole...
Confirming safety of chronic electrical stimulation is prime importance for the practical use visual prostheses. Here we applied to eyes freely-moving rabbits eight hour per day one month. Examinations including fundus photo, optical coherence tomography (OCT), electrically evoked potentials (EEPs) were performed before and after one-month detect tissue damage. No adverse effect caused by was observed in electrophysiological histological evaluation. We also found that there no sign...
Abstract We demonstrated a multi-point stimulation system using CMOS chips designed for distributed implantable retinal prostheses. The chip integrates current sources and electrode selection circuits. This integration enables control from multiple electrodes with minimal wires. In this study, we constructed validation 49 capable of visually observing outputs. results show that it is possible to configure conditions in approximately 9.3 μ s per electrode, the ability complete one frame,...
We have performed in vivo electric stimulation experiments on rabbit retina to demonstrate feasibility of CMOS LSI-based multi-chip flexible neural stimulator for retinal prosthesis. developed new packaging structure with an improved flexibility and device control system which totally controls the stimulator, counter electrode, generator. implanted fabricated into sclera pocket STS (Suprachoroidal Transretinal Stimulation) configuration. successfully obtained EEP (Electrically Evoked...
A CMOS integrated flexible neural interface device has been designed and fabricated. The enables electrical stimulation of tissues using an array smart electrodes. electrodes have versatile functions owing to the use a dedicated microchip. These multiple also provide with sophisticated only four wiring connections external equipment. Moreover, multi-chip architecture is highly low invasiveness living body tissue. An in vivo evaluation retinal was performed after implanting eye experimental...
A correlation between acquired renal cysts in the dialysed kidney and cancer has long been debated, but no changes physical properties of kidneys at microscopic level have reported. The purpose present study was to classify patients undergoing haemodialysis several stages pathology by use scanning acoustic microscope.Sixteen surgically excised dialysis were investigated. Tissues fixed 10% formalin, frozen acetone, cut 10 microns thick on a cryostat. We used microscope operated frequency...
The Functionality of a complementary metal oxide semiconductor (CMOS) LSI-based, multichip flexible retinal stimulator was demonstrated in stimulation experiments on rabbits. A 1×4-configured fabricated for application to animals. An experimental procedure including surgical operations developed, and performed with the stimulator. Neural responses visual cortex were successfully evoked by is confirmed be applicable acute animal experiments.
A visual prosthesis is an artificial sensory organ that transmits information to a blind person by electrically stimulating residual neurons in the nervous system. Such system requires large number of electrodes: It technically difficult connect stimulator placed behind ear each electrodes over any significant distance with high reliability. We propose containing multiplexer separately from unit. The array connected stimulation unit through multiplexer. and are onto suprachoroidal space....
A fork-shaped retinal stimulator for a wide viewing angle was fabricated and demonstrated.This has two flexible fork elements, each with stimulus head.The elements can be implanted at different places in the eyeball to cover wider area of retina.The head electrodes same shape as utilized clinical trial six weeks.Complementary metal-oxide semiconductor (CMOS) microchips were integrated into mounted next electrodes.Since current generators are microchips, no external wires required.A...
Abstract Implantable retinal prostheses are stimulation devices used to compensate for the light sensitivity loss of cells. In this study, we propose and demonstrate a novel method significantly reduce setting time conditions prosthesis chip capable multi-electrode stimulation. The efficiency control is increased while using only two wires, as in our previous work. comprises an 8 bit ID 7 electrodes, current value can be set from 50 1550 μ A. fabricated requires 32 pulses conditions, which...
This study focuses on the design of electrical stimulator for retinal prosthesis. The must be designed such that occurrence electrolysis or any irreversible process in electrodes and flexible lead is prevented order to achieve safe stimulation over long periods using large number electrodes. Some types biphasic current pulse circuits, charge balance AC power delivery circuits were developed address this issue. Electronic circuitry introduced required obtain high quality vision. concept a...