A5078853590- Neuroscience and Neural Engineering
- CCD and CMOS Imaging Sensors
- Advanced Fluorescence Microscopy Techniques
- Photoreceptor and optogenetics research
- Photonic and Optical Devices
- EEG and Brain-Computer Interfaces
- GaN-based semiconductor devices and materials
- Advanced Memory and Neural Computing
- Optical Imaging and Spectroscopy Techniques
- Optical Polarization and Ellipsometry
- Silicon Carbide Semiconductor Technologies
- Optical Coherence Tomography Applications
- Retinal Imaging and Analysis
- Infrared Target Detection Methodologies
- Neural dynamics and brain function
- Semiconductor materials and devices
- Biosensors and Analytical Detection
- Image Processing Techniques and Applications
- Spectroscopy Techniques in Biomedical and Chemical Research
- Analytical Chemistry and Sensors
- Ga2O3 and related materials
- Electrowetting and Microfluidic Technologies
- Photoacoustic and Ultrasonic Imaging
- Terahertz technology and applications
- Advanced Biosensing Techniques and Applications
Nara Institute of Science and Technology
2015-2025
National Archives and Records Administration
2024-2025
Japan Science and Technology Agency
2015-2016
Hiroshima University
2013
Kansai University
2013
University of Calcutta
2013
Furukawa Electric (United Kingdom)
2006
Furukawa Electric (Japan)
2002-2005
Abstract To advance the practical application of retinal prostheses with high spatial resolution through parallel stimulation, we developed a dynamic power supply voltage control system designed to enable stable constant-current stimulation in vivo, regardless number active points. The proposed prosthesis integrates CMOS chip, containing current sources and electrode selection circuits, into array implanted eye. This configuration facilitates individual over 1000 electrodes minimal wiring....
This paper introduces an image processing method, used to achieve uniform sensitivity across the imaging plane in a high-frequency electric field system, that employs electro-optical crystal and polarization sensor. The pixels have two directions, 0° 90°, pairs, and, conventionally, their difference is computed first. In contrast, this study proposes method separate each image, perform pixel completion, subsequently intensity correction. proposed was demonstrated improve distribution images...
An observation technique for animal brain activity under freely moving conditions is important to understand functions because an anesthetized condition different from that a nonanesthetized condition. We have developed ultrasmall CMOS imaging device conditions. This composed of image sensor chip and nine LEDs illumination. It weighs only 0.02 g its small size enables experiments be performed without restricting movement. feature advantageous imaging, particularly in situations. In this...
In this paper, we propose and demonstrate an implantable CMOS image sensor with self-resetting pixels. The function is implemented using a four-transistor Schmitt trigger inverter. pixel has no counter for the number of self-resets, because application does not require radiometric (linear) response. fabricated 0.35-μm 2-poly 4-metal standard technology, which results in size 15 μm×15 μm fill factor 31%. effective peak signal-to-noise ratio >59 dB. An prototype comprising 60 × 134 array...
In this article, We demonstrated an image sensor for detecting changes in polarization with high sensitivity.For purpose, we constructed optical system a two-layer structure, comprising external polarizer and polarizers on pixel array.An is used to enhance the rotation while reducing intensity avoid saturation of sensor.Using two can be arranged under optimal conditions achieve polarization-change detection performance.We fabricated using 0.35-µm CMOS process and, by averaging 50 × pixels 96...
In this research, we combined our ultralight micro-imaging device for calcium imaging with microdialysis to simultaneously visualize neural activity in the dorsal raphe nucleus (DRN) and measure serotonin release central of amygdala (CeA) anterior cingulate cortex (ACC). Using platform, observed brain following nociception induced by formalin injection mouse's hind paw. Our showed that DRN fluorescence intensity increased after injection, increase was highly correlated elevation both CeA...
The application of the fluorescence imaging method to living animals, together with use genetically engineered animals and synthesized photo-responsive compounds, is a powerful for investigating brain functions.Here, we report surface deep tissue that uses compact mass-producible semiconductor devices based on complementary metal-oxide (CMOS) technology.An image sensor chip was designed be inserted into tissue, its size 1500 × 450 μm.Sample illumination also key issue intravital...
Abstract In this paper, we propose an improved on-pixel polarizer structure for image sensor, which was fabricated using the 0.35 μ m standard CMOS process with dual metal layers (Metal 1 and Metal 2), i.e. two of gratings metal-wiring were stacked. By designing line/space ratio as 0.7/0.7 m, extinction significantly at a wavelength 780 nm, over 1.4 times higher than that single-layer grating, detection sensitivity polarization change enhanced by more 1.8 times. We also demonstrated...
An AlGaN/GaN HFET with a much lower on-state resistance is described and used in an inverter circuit. It was confirmed that the could be operated at current of over 20 A using gas-source molecular-beam epitaxy. The measured 8 mΩ cm2 370 V. Switching times were investigated; turn-on time found to 10 ns turn-off 11 ns. maximum operating frequency 0.37 GHz. circuit fabricated HFETs convert DC 30 V AC 100
Abstract Optical therapy and diagnostics using photoactivatable molecular tools are promising approaches in medical applications; however, a method for the delivery of light deep inside biological tissues remains challenge. Here, we present illumination detection implantable micro-optical semiconductor devices. Unlike conventional transdermal methods low-energy (>620 nm or near-infrared light), our method, high-energy (470 nm) can also be used illumination. Implanted submillimeter-sized...
Dopamine (DA) is the key regulator of reward behavior. The DA neurons in ventral tegmental area (VTA) and their projection areas, which include prefrontal cortex (PFC), nucleus accumbens (NAc), amygdala, play a primary role process reward-driven behavior induced by drugs addiction, including nicotine alcohol. In our previous study, we developed novel platform consisting micro-LED array devices to stimulate large brain rats monkeys with photo-stimulation microdialysis probe estimate release...
A brain functional imaging technique over a long period is important to understand functions related animal behavior. We have developed small implantable CMOS device for measuring activity in freely moving animals. This composed of image sensor chip and LEDs illumination. In this study, we demonstrated intrinsic signal blood flow using the with green LED light source at peak wavelength 535 nm, which corresponds one absorption spectral peaks cells. Brain increases regional flow. The weight...
A CMOS image sensor with stacked photodiodes was fabricated using 0.18 µm mixed signal process technology. Two were at the same position of each pixel sensor. The consist shallow high-concentration N-type layer (N + ), P-type well (PW), deep (DNW), and substrate (P-sub). PW P-sub shorted to ground. By monitoring voltage N DNW individually, we can observe two monochromatic colors simultaneously without any color filters. is suitable for fluorescence imaging, especially contact imaging such as...
Optogenetics is a powerful tool for controlling biological functions using light. Optical fibers have been extensively utilized in optical stimulation devices optogenetics. However, the use of results small photo-stimulation region. In this study, micro-LED array were developed to achieve large-area brain large animal, such as macaque monkeys. Planar and linear designed fabricated photo-stimulate prefrontal cortex (PFC) ventral tegmental area (VTA) induce neurochemical response. Device...
Fluorescence imaging devices have been indispensable in elucidating the workings of brain living animals, including unrestrained, active ones. Various are available, each with their own strengths and weaknesses terms many factors. We developed CMOS-based needle-type that small lightweight enough to be doubly implanted freely moving mice. The design also allowed angled implantations avoid critical areas. demonstrated utility by using them on GCaMP6 mice a formalin test experiment....
In this study, we demonstrate a reflective imaging system in which dual polarizer structure, consisting of uniform and on the pixel polarization image sensor, enables detection weak changes. The can achieve high extinction ratio is used to render amount change condition that easily detectable by sensor. sensor uses two types polarizers arranged an orthogonal relationship with each other obtain complementary signals for rotation. This also differential reduce in-phase noise components....
Abstract We demonstrated a multi-point stimulation system using CMOS chips designed for distributed implantable retinal prostheses. The chip integrates current sources and electrode selection circuits. This integration enables control from multiple electrodes with minimal wires. In this study, we constructed validation 49 capable of visually observing outputs. results show that it is possible to configure conditions in approximately 9.3 μ s per electrode, the ability complete one frame,...
We propose and demonstrate a method for equivalent time sampling using image sensors to selectively detect only the target frequency. Shortening exposure of sensor allows detection frequency components that are higher than frame rate. However, imaging system in our previous work was also sensitive component at 1/4 In this study, we control phase relationship between observed signal by inserting an additional interval once every four frames selectively. With technique, conducted electric...
In this study, a polarisation-analysing CMOS image sensor is fabricated for sensitive polarisation modulation detection. Although the with on-pixel polarisers can incident collectively, its sensitivity to weak change not high. With proposed method, an external polariser used enhance sensor. The performance of highly and imaging experiments are evaluated using flow channel.
Dopamine (DA) is the most important neurotransmitter involved in motor control. Abnormalities levels may indicate brain disorders, such as Parkinson’s disease and depression. Herein, electrochemical sensors containing metal oxide nanoparticles were fabricated for detecting DA. Specifically, iron applied onto a flexible polyimide substrate to obtain microelectrode their DA detection performance was evaluated vitro vivo. The of sensor via fast-scan cyclic voltammetry conducted solution at...
In this study, we developed and demonstrated a millimeter-wave electric field imaging system using an electro-optic crystal highly sensitive polarization measurement technique image sensor, which was fabricated 0.35-µm standard CMOS process. The sensor equipped with differential amplifiers that amplified the difference between 0° 90° pixels. With amplifier, signal-to-noise ratio at low incident light levels improved. Also, optical modulator semiconductor amplifier were used to generate local...
Abstract Digital enzyme-linked immunosorbent assay (ELISA) is used for detecting various biomarkers with hypersensitivity. We have been developing compact systems by replacing the fluorescence microscope a CMOS image sensor. Here, we propose micro-light-pipe array structure made of metal filled dye-doped resin, which can be as fabrication substrate micro-reaction-chamber digital ELISA. The possibility that this enhances coupling efficiency was simulated using simple model. To realize...